Cobalt‐Catalyzed Enantioselective Reductive α‐Chloro‐Carbonyl Addition of Ketimine to Construct the β‐Tertiary Amino Acid Analogues
Tingting Xia,
Wenwen Wu,
Xianqing Wu
et al.
Abstract:β‐Tertiary amino acid derivatives constitute one of the most frequently occurring units in natural products and bioactive molecules. However, the efficient asymmetric synthesis of this motif still remains a significant challenge. Herein, we disclose a cobalt‐catalyzed enantioselective reductive addition reaction of ketimine using α‐chloro carbonyl compound as a radical precursor, providing expedient access to a diverse array of enantioenriched β‐quaternary amino acid analogues. This protocol exhibits outstandi… Show more
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