Cobalt-based metal–organic framework as a dual cooperative controllable release system for accelerating diabetic wound healing

Li, Jiankai; Lv, Fang; Li, Jinxiu; Li, Yuxin; Gao, Jingduo; Luo, Jian; Xue, Feng; Ke, Qinfei; He, Xu

doi:10.1007/s12274-020-2846-1

Cited by 54 publications

(28 citation statements)

References 64 publications

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“…Li et al prepared a cobalt-based metal-organic framework (MOF, ZIF-67) into micro-patterned PLLA/Gel NF scaffolds as a carrier for loading a small molecular drug (DMOG). The results confirmed that cobalt-based metal-organic framework as a dual cooperative controllable release system provides a new strategy for eliminating inflammation, enhancing collagen deposition and angiogenesis, and promoting DW healing [166].…”

Section: Metal-based Matssupporting

confidence: 61%

Nanofiber-based systems intended for diabetes

et al. 2021

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Diabetic mellitus (DM) is the most communal metabolic disease resulting from a defect in insulin secretion, causing hyperglycemia by promoting the progressive destruction of pancreatic β cells. This autoimmune disease causes many severe disorders leading to organ failure, lower extremity amputations, and ultimately death. Modern delivery systems e.g., nanofiber (NF)-based systems fabricated by natural and synthetic or both materials to deliver therapeutics agents and cells, could be the harbinger of a new era to obviate DM complications. Such delivery systems can effectively deliver macromolecules (insulin) and small molecules. Besides, NF scaffolds can provide an ideal microenvironment to cell therapy for pancreatic β cell transplantation and pancreatic tissue engineering. Numerous studies indicated the potential usage of therapeutics/cells-incorporated NF mats to proliferate/regenerate/remodeling the structural and functional properties of diabetic skin ulcers. Thus, we intended to discuss the aforementioned features of the NF system for DM complications in detail. Graphic abstract

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Section: Metal-based Matssupporting

confidence: 61%

Nanofiber-based systems intended for diabetes

et al. 2021

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“…[ 2 ] Diabetic ulcer which mostly occurs in the feet is one of the main complications of diabetes, resulting in influencing the life quality of patients’ life and even amputation sometimes. [ 3 ] For chronic wounds, especially the diabetic wounds, persistent inflammation and bacterial infection are the two main reasons that inhibit wound healing. [ 4 ] Due to the hyperglycemic environment around the wound, diabetic ulcer is susceptible to bacteria and difficult to heal.…”

Section: Introductionmentioning

confidence: 99%

A Smart Nanoplatform with Photothermal Antibacterial Capability and Antioxidant Activity for Chronic Wound Healing

Zhai

Huang

et al. 2021

Adv Healthcare Materials

124

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Chronic wounds, such as the diabetic ulcer wounds have serious effect on people's lives, and can even lead to death. Diabetic ulcer wounds are different from normal wounds and much easier to be infected and induce oxidative stress due to the special surrounding microenvironment, which makes it necessary to prepare materials with antibacterial property and antioxidant activity simultaneously. The molybdenum disulfide‐ceria (MoS2‐CeO2) nanocomposite possesses both the photo‐thermal therapy (PTT) antibacterial capability of polyethylene glycol modified molybdenum disulfide nanosheets and the antioxidant activity of cerium dioxide nanoparticles (CeO2 NPs). By combining the inherent antibacterial activity of CeO2 NPs, the MoS2‐CeO2 nanocomposite exhibits excellent PTT antibacterial capability against both gram‐positive and gram‐negative bacteria through 808 nm laser treatment, thereby reducing the risk of wound infection. Owing to the abundant oxygen vacancies in CeO2 NPs, Ce3+ and Ce4+ can transform reversibly which endows MoS2‐CeO2 nanocomposite with remarkable antioxidant ability to clear away the excessive reactive oxygen species around the diabetic ulcer wounds and promote wound healing. The results demonstrate that MoS2‐CeO2 nanocomposite is a promising class for the clinical treatment of chronic wounds especially the diabetic ulcer wounds, and 808 nm laser can be used as a PTT antibacterial switch.

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“…Metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) have recently attracted much attention as drug carriers for therapeutic applications. [ 136–138 ] MOFs‐ and COFs‐based materials that can maintain constant conductivity in physiological solutions may have the potential to be incorporated into electroactive dressings for healing wounds. Additionally, carbon‐ and metal‐based materials cannot be degraded in vivo and may have cytotoxicity owing to their size, structure, surface functionality, or porosity, [ 139,140 ] which should be thoroughly evaluated before they can be incorporated in the composite dressings for clinical applications.…”

Section: Future Perspectivesmentioning

confidence: 99%

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

Korupalli

Nguyen

et al. 2020

Adv Healthcare Materials

108

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The use of conductive materials to promote the activity of electrically responsive cells is an effective means of accelerating wound healing. This article focuses on recent advancements in conductive materials, with emphasis on overviewing their incorporation with non‐conducting polymers to fabricate electroactive wound dressings. The characteristics of these electroactive dressings are deliberated, and the mechanisms on how they accelerate the wound healing process are discussed. Potential directions for the future development of electroactive wound dressings and their potential in monitoring the course of wound healing in vivo concomitantly are also proposed.

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Cobalt-based metal–organic framework as a dual cooperative controllable release system for accelerating diabetic wound healing

Cited by 54 publications

References 64 publications

Nanofiber-based systems intended for diabetes

Nanofiber-based systems intended for diabetes

A Smart Nanoplatform with Photothermal Antibacterial Capability and Antioxidant Activity for Chronic Wound Healing

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

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