Cobalamin Supplementation Improves Cognitive and Cerebral Function in Older, Cobalamin-Deficient Persons

Asselt, D.Z.B. van; Pasman, J.W.; Lier, H. J. J. Van; Vingerhoets, D.M.; Poels, P.J.E.; Kuin, Y.; Blom, Henk J.; Hoefnagels, W.H.L.

doi:10.1093/gerona/56.12.m775

Cited by 60 publications

(48 citation statements)

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“…8) (1, 53, 54, 125 ) and those who would benefit from treatment ( Fig. 9) (49,82,127,139 ). High tHcy or MMA concentrations may also help to identify individuals at risk of developing adverse effects from drugs that interfere with folate or cobalamin status (140 -142 ).…”

Section: Comparison Of Blood Tests No Single Blood Test Used For Assmentioning

confidence: 99%

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

et al. 2004

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Background: Measurement of plasma total homocysteine has become common as new methods have been introduced. A wide range of disorders are associated with increased concentrations of total homocysteine. The purpose of this review is to provide an international expert opinion on the practical aspects of total homocysteine determinations in clinical practice and in the research setting and on the relevance of total homocysteine measurements as diagnostic or screening tests in several target populations. Methods: Published data available on Medline were used as the basis for the recommendations. Drafts of the recommendations were critically discussed at meetings over a period of 3 years. Outcome: This review is divided into two sections: (a) determination of homocysteine (methods and their performance, sample collection and handling, biological determinants, reference intervals, within-person variability, and methionine loading test); and (b) risk assessment and disease diagnosis (homocystinuria, folate and cobalamin deficiencies, cardiovascular disease, renal failure, psychiatric disorders and cognitive impairment, pregnancy complications and birth defects, and screening of elderly and newborns). Each of these subsections concludes with a separate series of recommendations to assist the clinician and the research scientist in making informed decisions. The review concludes with a list of unresolved questions. © 2004 American Association for Clinical ChemistryIncreased plasma total homocysteine (tHcy) 7 is a sensitive marker of folate and cobalamin (vitamin B 12 ) deficiency (1, 2 ) and an independent risk factor for cardiovascular disease (CVD) (3,4 ). Plasma tHcy concentrations are also related to birth defects (5 ), pregnancy complications (6 ), psychiatric disorders (7 ), and cognitive impairment in the elderly (8 ). The measurement of tHcy in the clinical setting is thus potentially of great importance (9 ).The introduction of tHcy assays in the mid-1980s (10, 11 ) started a new era of research on Hcy. However, it was the advent of immunoassays in the latter half of the 1990s (12, 13 ) that changed tHcy determinations from research tools to widely used clinical chemistry tests. As a result, interest in this field has increased exponentially in both routine diagnostics and research.Although several reviews on tHcy determinations have been published (14 -18 ), few have provided recommendations for their use in clinical practice (19 -23 ). Our aim was to review the practical aspects of tHcy determinations in clinical practice as well as in the research setting and to survey the data on tHcy in diagnostics or as screening tests in several target populations.Ideally, guidelines should be established by a multidisciplinary team including all relevant stakeholders, and the recommendations should be according to evidence-based medicine (24 ). There are not sufficient data in the Hcy field, however, to use such an approach. In particular, -32 (2004) Review 3 data from controlled clinical trials are sparse. Neverth...

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Section: Comparison Of Blood Tests No Single Blood Test Used For Assmentioning

confidence: 99%

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

et al. 2004

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“…9 Of the 189 who responded, 28 (14Í8%) had low (4150 pmol/L) plasma cobalamin levels, of whom 16 agreed to participate. Two subjects dropped out: one found the protocol burdensome and one was diagnosed with a lung tumour and died shortly afterwards.…”

Section: Methodsmentioning

confidence: 99%

Cobalamin-binding proteins in normal and cobalamin-deficient older subjects

et al. 2003

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“…So little is known about the direct effects of subclinical deficiency on health that its course, prognosis, and the need for therapy remain matters of opinion rather than fact. Subclinical neurocognitive and electrophysiological changes of undetermined impact have sometimes been noted [18][19][20]. Health consequences are unproven but remain conceivable even in the subclinical state, perhaps especially in susceptible subpopulations such as children.…”

Section: Binding Of Vitamin B 12 In Food Affects Its Bioavailabilitymentioning

confidence: 99%

Efficacy and Safety of Fortification and Supplementation with Vitamin B₁₂: Biochemical and Physiological Effects

Carmel

2008

Food Nutr Bull

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Cobalamin Supplementation Improves Cognitive and Cerebral Function in Older, Cobalamin-Deficient Persons

Cited by 60 publications

References 21 publications

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

Cobalamin-binding proteins in normal and cobalamin-deficient older subjects

Efficacy and Safety of Fortification and Supplementation with Vitamin B₁₂: Biochemical and Physiological Effects

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Cobalamin Supplementation Improves Cognitive and Cerebral Function in Older, Cobalamin-Deficient Persons

Cited by 60 publications

References 21 publications

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion

Cobalamin-binding proteins in normal and cobalamin-deficient older subjects

Efficacy and Safety of Fortification and Supplementation with Vitamin B12: Biochemical and Physiological Effects

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Efficacy and Safety of Fortification and Supplementation with Vitamin B₁₂: Biochemical and Physiological Effects