Cobalamin Reduces Homocysteine in Older Adults on Folic Acid–Fortified Diet: A Pilot, Double‐Blind, Randomized, Placebo‐Controlled Trial

Effect of B Vitamins and Lowering Homocysteine on Cognitive Impairment in Patients With Previous Stroke or Transient Ischemic Attack

“…Despite the above limitations, our results in patients with previous stroke are consistent with other randomized trials of homocysteine-lowering treatment for cognitive decline among cognitively unimpaired and impaired older people without stroke (Figure). [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] Furthermore, our results more than double the current database, adding data from 2214 patients to a previous pool of 721 cognitively unimpaired patients and 481 patients to a previous pool of 854 cognitively impaired patients, and thereby substantially increase the precision of the estimate of the effect of B-vitamins on cognitive function as measured by the MMSE.…”

“…Randomized trials of the effect of lowering tHcy with B-vitamins (folic acid, B12 and, to a lesser extent, B6) on cognitive decline minimize confounding and reverse causality but have produced conflicting or equivocal results. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The 2 trials that reported a benefit from lowering tHcy did so in subjects with elevated tHcy. 19,27 In view of the uncertainty of the effect of lowering tHcy with B-vitamins on cognition, we aimed to assess, in a prespecified study, whether B-vitamin treatment would reduce the incidence of new cognitive impairment among cognitively unimpaired individuals with recent stroke or transient ischemic attack (TIA) of the brain enrolled in the VITAmins TO Prevent Stroke (VITATOPS) trial, 29,30 and whether the effect of B-vitamins on cognitive function may be augmented in, or limited to, participants with elevated tHcy.…”

Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo‐controlled trial

“…Results of this study concur with previous research that demonstrates a consistent effect of homocysteine reduction with B‐group vitamin supplementation (Lewerin et al ., ; Garcia et al ., ). With multivitamin supplementation, homocysteine has been demonstrated to decrease after 12 (Earnest et al ., ) and 16 weeks (Summers et al ., ).…”

The effect of vitamin B12 and folic acid supplementation on routine haematological parameters in older people: an individual participant data meta-analysis

“…Eight authors could not provide haematological data because these were not measured or because individual data were not available anymore. Seven authors did not respond to our request [21][22][23][24][25][26][27]. The authors of the other 32 papers (n = 10 for vitamin B12 and n = 22 for folic acid) agreed to participate in this project and to share their data on haemoglobin concentrations or haematocrit fractions after supplementation.…”