Cobalamin and folate status predicts mental development scores in North Indian children 12–18 mo of age

Strand, Tor A.; Taneja, Sunita; Ueland, Per Magne; Refsum, Helga; Bahl, Rajiv; Schneede, Joern; Sommerfelt, Halvor; Bhandari, Nita

doi:10.3945/ajcn.111.032268

Cited by 93 publications

(72 citation statements)

References 32 publications

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“…Findings from observational studies that evaluated the associations between child vitamin B-12 status or intake and cognitive outcomes were more consistent: higher child vitamin B-12 status was associated with improved cognitive performance (52,58), school performance (56,57,59), and developmental indexes (54,55) in several studies. However, one cross-sectional study suggested that higher child vitamin B-12 status was associated with poorer cognitive measures (51), and a large population-based study did not report any significant associations between vitamin B-12 status and cognition in children (53).…”

Section: Discussionmentioning

confidence: 88%

“…Higher child plasma vitamin B-12 concentrations were associated with significantly higher BSID-II mental development scores (1.3; 95% CI: 0.2, 2.4; P = 0.02) (54). Similarly, higher plasma MMA (1.1; 95% CI: 0.3, 1.8; P = 0.004) and tHcy (2.0; 95% CI: 0.5, 3.4; P = 0.007) concentrations were associated with lower BSID-II mental development scores (54). The effects of vitamin B-12 and/or folic acid supplementation on early child development were assessed in a recent randomized controlled trial in India (55).…”

Section: Literature Reviewmentioning

confidence: 96%

“…In a prospective cohort study in India, investigators examined the associations between vitamin B-12 status (i.e., plasma total vitamin B-12, MMA, and tHcy) and neurocognitive development (BSID-II) in children 12-18 mo of age (54). Higher child plasma vitamin B-12 concentrations were associated with significantly higher BSID-II mental development scores (1.3; 95% CI: 0.2, 2.4; P = 0.02) (54).…”

Section: Literature Reviewmentioning

confidence: 99%

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Vitamin B-12 and Cognition in Children

Venkatramanan¹,

Armata²,

Strupp

et al. 2016

Advances in Nutrition

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Vitamin B-12 is essential for brain development, neural myelination, and cognitive function. Inadequate vitamin B-12 status during pregnancy and early childhood has been associated with adverse child health outcomes, including impaired cognitive development. However, the underlying mechanisms have not been elucidated. This review was conducted to examine the evidence that links vitamin B-12 and cognition in children. The search strategy resulted in 17 studies: 3 cross-sectional, 1 case-control, and 12 cohort studies, and 1 randomized trial. Cognitive processes assessed included attention, memory, and perception. Developmental outcomes, academic performance, and intelligence quotient were also considered. Despite the high prevalence of vitamin B-12 insufficiency and associated risk of adverse cognitive outcomes in children, to our knowledge, no studies to date have been conducted to examine the effects of vitamin B-12 supplementation on cognition in children. The role of vitamin B-12 in the etiology of child cognitive outcomes needs to be elucidated to inform public health interventions. Adv Nutr 2016;7:879-88.

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Section: Discussionmentioning

confidence: 88%

Section: Literature Reviewmentioning

confidence: 96%

Section: Literature Reviewmentioning

confidence: 99%

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Vitamin B-12 and Cognition in Children

Venkatramanan¹,

Armata²,

Strupp

et al. 2016

Advances in Nutrition

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“…A recent study by Strand et al (34) reported that low plasma folate and vitamin B 12 concentrations were associated with poorer cognitive performance, measured in children aged 12-18 months. Furthermore, an investigation of Swedish adolescents (age 15 years) showed that higher dietary folate intakes was positively associated with academic achievements (35) .…”

Section: Metabolism B-vitamins and Early Brain Healthmentioning

confidence: 99%

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

et al. 2014

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Nutrition plays a fundamental role in supporting the structural and functional development of the human brain from conception, throughout early infancy and extending into later life. A growing body of evidence suggests that folate and the metabolically related B-vitamins are essential for brain health across all age groups, owing to their specific roles in C 1 metabolism and particularly in the production of S-adenosylmethionine, a universal methyl donor essential for the production of neurotransmitters. Emerging, though not entirely consistent, evidence suggests that maternal folate status throughout pregnancy may influence neurodevelopment and behaviour of the offspring. Furthermore optimal B-vitamin status is associated with better cognitive health in ageing. Of note, a recent clinical trial provided evidence that supplementation with folic acid and related B-vitamins over a 2-year-period reduced global and regional brain atrophy, as measured by MRI scan in older adults. In terms of potential mechanisms, the effects of these B-vitamins on cognitive health may be independent or may be mediated by nutrient-nutrient and/or relevant gene-nutrient interactions. Furthermore, a new area of research suggests that the in utero environment influences health in later life. Folate, an important cofactor in C 1 metabolism, is indirectly involved in DNA methylation, which in turn is considered to be one of the epigenetic mechanisms that may underlie fetal programming and brain development. The present review will explore the evidence that supports a role for folate and the related B-vitamins in brain health across the lifecycle, and potential mechanisms to explain such effects.

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“…A limited number of clinical studies in children demonstrated a correlation between vitamin B 12 deficiency and cognition. 1,2 Studies in elderly subjects suggest that vitamin B 12 deficiency is associated with cognitive decline and may contribute to Alzheimer dementia, 3,4 whereas others have failed to demonstrated an increased risk. 5,6 Subjects with B 12 deficiency may also show changes in the posterolateral column of the spinal cord on MR imaging.…”

mentioning

confidence: 99%

DTI Correlates of Cognition in Conventional MRI of Normal-Appearing Brain in Patients with Clinical Features of Subacute Combined Degeneration and Biochemically Proven Vitamin B12 Deficiency

Gupta

Garg

et al. 2013

American Journal of Neuroradiology

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Cobalamin and folate status predicts mental development scores in North Indian children 12–18 mo of age

Abstract: Cobalamin and folate status showed a statistically significant association with cognitive performance. Given the high prevalence of deficiencies in these nutrients, folate and cobalamin supplementation trials are required to measure any beneficial effect on cognition.

Cited by 93 publications

References 32 publications

Vitamin B-12 and Cognition in Children

Vitamin B-12 and Cognition in Children

Emerging roles for folate and related B-vitamins in brain health across the lifecycle

DTI Correlates of Cognition in Conventional MRI of Normal-Appearing Brain in Patients with Clinical Features of Subacute Combined Degeneration and Biochemically Proven Vitamin B12 Deficiency

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