Coaxially fabricated polylactic acid electrospun nanofibrous scaffold for sequential release of tauroursodeoxycholic acid and bone morphogenic protein2 to stimulate angiogenesis and bone regeneration

Bhattarai, Deval Prasad; Kim, Min Hee; Park, Ho; Park, Won Ho; Kim, Beom Su; Kim, Cheol Sang

doi:10.1016/j.cej.2019.123470

Cited by 49 publications

(23 citation statements)

References 48 publications

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“…By providing a sequential release of first BMP-2 and then VEGF, accelerated bone healing due to efficiently improved osteogenesis and angiogenesis was obtained. Bhattarai et al Loaded BMP-2 and tauroursodeoxycholic acid (TUDCA) respectively in coaxial electrospun PLA fibers [ 27 ]. The TUDCA/BMP-2 coaxial fiber scaffolds promoted angiogenic and osteogenic differentiation in ECs and MSCs, respectively.…”

Section: Resultsmentioning

confidence: 99%

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

Wang

Lai

et al. 2021

Bioactive Materials

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Three-dimensional (3D) printing has been increasingly employed to produce advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths, in order to induce improved bone regeneration in defects with a critical size. Given that the successful bone regeneration requires both excellent osteogenesis and vascularization, endowing scaffolds with both strong bone forming ability and favorable angiogenic potential would be highly desirable to induce improved bone regeneration with required vascularization. In this investigation, customized bone tissue engineering scaffolds with balanced osteoconductivity/osteoinductivity were produced via cryogenic 3D printing of β-tricalcium phosphate and osteogenic peptide (OP) containing water/poly(lactic- co -glycolic acid)/dichloromethane emulsion inks. The fabricated scaffolds had a hierarchically porous structure and were mechanically comparable to human cancellous bone. Angiogenic peptide (AP) containing collagen I hydrogel was then coated on scaffold surface to further provide scaffolds with angiogenic capability. A sequential release with a quick AP release and a slow but sustained OP release was obtained for the scaffolds. Both rat endothelial cells (ECs) and rat bone marrow derived mesenchymal stem cells (MSCs) showed high viability on scaffolds. Improved in vitro migration and angiogenesis of ECs were obtained for scaffolds delivered with AP while enhanced osteogenic differentiation was observed in scaffolds containing OP. The in vivo results showed that, toward scaffolds containing both AP and OP, the quick release of AP induced obvious angiogenesis in vivo , while the sustained OP release significantly improved the new bone formation. This study provides a facile method to produce dual-delivery scaffolds to achieve multiple functions.

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Section: Resultsmentioning

confidence: 99%

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

Wang

Lai

et al. 2021

Bioactive Materials

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“…Currently, electrospinning is a versatile method for the facile production of nanofibrous structures with diverse structures and functionalities for a variety of advanced technologies. The morphology, structure, and functionality of the nanofibrous material are determined by the nature of the polymer, solvent, and processing parameters [85,86]. Currently, a large number of natural and synthetic polymers have been successfully reported for the fabrication of nanofibers by electrospinning [71].…”

Section: Electrospun-based Fibers As Negative Electrode Materials For Supercapacitorsmentioning

confidence: 99%

“…Electrochem 2021, 2, FOR PEER REVIEW 6 nanofibrous material are determined by the nature of the polymer, solvent, and processing parameters [85,86]. Currently, a large number of natural and synthetic polymers have been successfully reported for the fabrication of nanofibers by electrospinning [71].…”

Section: Electrospun-based Fibers As Negative Electrode Materials For Supercapacitorsmentioning

confidence: 99%

A Review of Electrospun Carbon Nanofiber-Based Negative Electrode Materials for Supercapacitors

Tiwari¹,

Mukhiya

Muthurasu

et al. 2021

Electrochem

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The development of smart negative electrode materials with high capacitance for the uses in supercapacitors remains challenging. Although several types of electrode materials with high capacitance in energy storage have been reported, carbon-based materials are the most reliable electrodes due to their high conductivity, high power density, and excellent stability. The most common complaint about general carbon materials is that these electrode materials can hardly ever be used as free-standing electrodes. Free-standing carbon-based electrodes are in high demand and are a passionate topic of energy storage research. Electrospun nanofibers are a potential candidate to fill this gap. However, the as-spun carbon nanofibers (ECNFs) have low capacitance and low energy density on their own. To overcome the limitations of pure CNFs, increasing surface area, heteroatom doping and metal doping have been chosen. In this review, we introduce the negative electrode materials that have been developed so far. Moreover, this review focuses on the advances of electrospun nanofiber-based negative electrode materials and their limitations. We put forth a future perspective on how these limitations can be overcome to meet the demands of next-generation smart devices.

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“…Many studies in the literature reports the use of three-dimensional nanostructured scaffolds with drug delivery capabilities for bone tissue regeneration. [66][67][68][69][70] A mesoporous silicate nanoparticle incorporated-nanofibrous gelatin scaffold was designed for the dual delivery of bone morphogenic protein 2 and deferoxamine serving as a biomimetic osteogenic environment. [71] The results showed that the designed scaffold had the ability to control the dual drug delivery of bone morphogenic protein 2 and deferoxamine at distinct release rates, while maintaining their osteogenic and angiogenic abilities, respectively.…”

Section: Bone Regenerationmentioning

confidence: 99%

Nanotechnology-based drug delivery systems in orthopedics

Güven

2021

Jt Dis Relat Surg

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Nanotechnology is a multidisciplinary branch of science which involves the manipulation and control of matter at the nanometer scale to produce new structures, materials, and devices. The concept of nanotechnology was first introduced by Richard P. Feynman [1] in 1959. Since then, nanotechnology has become a research area which promises advancements in many aspects of human life, including electronics, agriculture, transportation, food industry, communication, energy, biological sciences, and medicine. Nanomedicine, the application of nanotechnology in the field of medicine, has the potential to make a great impact on human health and has already impacted and reshaped many aspects of clinical practice and research. Nanotechnology-based materials with unique physical, chemical, and biological characteristics offer a variety of new approaches for clinical practices ranging from prevention to treatment and diagnosis of many diseases and conditions. [2][3][4][5] Among all the applications of nanotechnology in medicine, nano-based drugIn recent years, nanotechnology has led to significant scientific and technological advances in diverse fields, specifically within the field of medicine. Owing to the revolutionary implications in drug delivery, nanotechnology-based drug delivery systems have gained an increasing research interest in the current medical field. A variety of nanomaterials with unique physical, chemical and biological properties have been engineered to develop new drug delivery systems for the local, sustained and targeted delivery of drugs with improved therapeutic efficiency and less or no toxicity, representing a very promising approach for the effective management of diseases. The utility of nanotechnology, particularly in the field of orthopedics, is a topic of extensive research. Nanotechnology has a great potential to revolutionize treatment, diagnostics, and research in the field of orthopedics. Nanophase drug delivery has shown great promise in their ability to deliver drugs at nanoscale for a variety of orthopedic applications. In this review, we discuss recent advances in the field of nanostructured drug delivery systems for orthopedic applications.

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Coaxially fabricated polylactic acid electrospun nanofibrous scaffold for sequential release of tauroursodeoxycholic acid and bone morphogenic protein2 to stimulate angiogenesis and bone regeneration

Cited by 49 publications

References 48 publications

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization

A Review of Electrospun Carbon Nanofiber-Based Negative Electrode Materials for Supercapacitors

Nanotechnology-based drug delivery systems in orthopedics

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