Coaxial projective imaging for sentinel lymph node mapping in melanoma

Zhang, Ru; Yang, BS; Zhongliang, Lang; Wu, BS Bingxuan; Shao, Pengfei; Liu, Peng; Zhong, Xiao‐bo; Xu, Ronald X.

doi:10.1016/j.jdcr.2021.06.023

Cited by 2 publications

(1 citation statement)

References 9 publications

(9 reference statements)

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“…Projection overlay systems described in the literature use a single image modality to survey the tissue of interest and then produce a visible projection to guide a clinician through a standard clinical procedure. For example, groups have developed near infrared uorescence-based overlay imaging systems for parathyroid gland visualization [37][38][39] , sentinel lymph node detection in breast cancer and melanoma [40][41][42][43] , real-time navigation for liver surgery 44,45 , and interactive tele-mentoring 46 . Yet, these systems rely on intravenous dyes to provide image contrast.…”

mentioning

confidence: 99%

Multiscale Optical Imaging with Real Time Projection of Cancer Risk and Biopsy Guidance Maps for Early Oral Cancer Diagnosis and Treatment

Coole

Brenes

Mitbander

et al. 2022

Preprint

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When detected early, oral precancer and cancer can be treated with surgical resection with successful long-term clinical outcomes. Despite easy accessibility of the oral cavity, conventional oral examination has limited sensitivity and specificity to detect early neoplastic changes. Several optical imaging tools have shown promise to improve early detection of oral neoplasia, but they do not provide visible guidance to help clinicians determine when and where to biopsy suspicious oral lesions. Here, we demonstrate a low-cost, portable Active Biopsy Guidance System (ABGS) that uses multi-scale optical imaging with deep learning algorithms to create and directly project cancer risk maps onto clinically visible oral potentially malignant disorders (OPMDs) to guide biopsy locations in real time. Representative patient examples highlight these clinically actionable visualizations that are provided in real-time during an imaging procedure through automated processing of imaging data. Results show multiscale optical imaging with cancer-risk map projection offers a versatile, quantitative and precise tool to guide biopsy site selection and improve the early detection of oral epithelial cancers and their precursors.

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