Coatings for Microneural Implants: Biological and Mechanical Considerations

Olczak, Kaitlynn P.; Otto, Kevin J.

doi:10.1007/978-981-15-2848-4_132-1

Cited by 1 publication

(1 citation statement)

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“…There are several reviews that focus on these organic conductors and while they hold much promise for standalone bioelectronics, there remain challenges with safety and efficacy for implantable devices. [ 6 , 7 , 8 , 9 , 10 ] However, organic conductors hold significant promise as electrode coatings for improving neural interfaces in the near term, with lower clinical and regulatory hurdles than standalone organic bioelectronics.…”

Section: Introductionmentioning

confidence: 99%

Bioelectronic Neural Interfaces: Improving Neuromodulation Through Organic Conductive Coatings

Duan,

Robles,

Poole‐Warren

et al. 2023

Advanced Science

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Integration of bioelectronic devices in clinical practice is expanding rapidly, focusing on conditions ranging from sensory to neurological and mental health disorders. While platinum (Pt) electrodes in neuromodulation devices such as cochlear implants and deep brain stimulators have shown promising results, challenges still affect their long‐term performance. Key among these are electrode and device longevity in vivo, and formation of encapsulating fibrous tissue. To overcome these challenges, organic conductors with unique chemical and physical properties are being explored. They hold great promise as coatings for neural interfaces, offering more rapid regulatory pathways and clinical implementation than standalone bioelectronics. This study provides a comprehensive review of the potential benefits of organic coatings in neuromodulation electrodes and the challenges that limit their effective integration into existing devices. It discusses issues related to metallic electrode use and introduces physical, electrical, and biological properties of organic coatings applied in neuromodulation. Furthermore, previously reported challenges related to organic coating stability, durability, manufacturing, and biocompatibility are thoroughly reviewed and proposed coating adhesion mechanisms are summarized. Understanding organic coating properties, modifications, and current challenges of organic coatings in clinical and industrial settings is expected to provide valuable insights for their future development and integration into organic bioelectronics.

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