Coating of Multiparticulates for Sustained Release

Tang, Elaine S. K.; Chan, Lai Wah; Heng, Paul Wan Sia

doi:10.2165/00137696-200503010-00003

Cited by 61 publications

(32 citation statements)

References 103 publications

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“…Multiparticulate extended release dosage forms are preferred over single unit dosage forms due to their uniform spreading throughout the gastrointestinal tract, which offers major therapeutic benefits of reduced inter-and intrapatient variability (1)(2)(3). Extended release multiparticulate dosage forms are generally prepared by application of a barrier membrane coating (3).…”

Section: Introductionmentioning

confidence: 99%

“…Extended release multiparticulate dosage forms are generally prepared by application of a barrier membrane coating (3). The extended release characteristic helps to maintain the therapeutic dose of a drug over a prolonged period of time to improve patient compliance, mitigate side effects, and in some cases, allow site-specific drug release (3,4).…”

Section: Introductionmentioning

confidence: 99%

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Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of Metoprolol Tartrate and Acetaminophen Extended Release Multiparticulates—Part I

Mehta

Teckoe

Schoener³

et al. 2016

AAPS PharmSciTech

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Abstract. Ethylcellulose is one of the most commonly used polymers to develop reservoir type extended release multiparticulate dosage forms. For multiparticulate extended release dosage forms, the drug release is typically governed by the properties of the barrier membrane coating. The ICH Pharmaceutical Development Guideline (ICH Q8) requires an understanding of the influence of critical material attributes and critical process parameters on the drug release of a pharmaceutical product. Using this understanding, it is possible to develop robust formulations with consistent drug release characteristics. Critical material attributes for ethylcellulose were evaluated, and polymer molecular weight variation (viscosity) was considered to be the most critical attribute that can impact drug release. To investigate the effect of viscosity variation within the manufacturer's specifications of ethylcellulose, extended release multiparticulate formulations of two model drugs, metoprolol tartrate and acetaminophen, were developed using ETHOCEL™ as the rate controlling polymer. Quality by Design (QbD) samples of ETHOCEL Std. 10, 20, and 100 Premium grades representing the low, medium, and high molecular weight (viscosity) material were organically coated onto drug layered multiparticulates to a 15% weight gain (WG). The drug release was found to be similar (f 2 > 50) for both metoprolol tartrate and acetaminophen multiparticulates at different coating weight gains of ethylcellulose, highlighting consistent and robust drug release performance. The use of ETHOCEL QbD samples also serves as a means to develop multiparticulate dosage formulations according to regulatory guidelines.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of Metoprolol Tartrate and Acetaminophen Extended Release Multiparticulates—Part I

Mehta

Teckoe

Schoener³

et al. 2016

AAPS PharmSciTech

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“…Hence in theory they are less likely to be associated with systemic symptoms related with rapid high peaks of drug plasma concentrations. 16 Having pH sensitive coating on some of them, allows targeted drug release delivery in specific areas of GI system. 19 Some drugs e.g.…”

Section: 9mentioning

confidence: 99%

Ghost pill: knowledge and awareness of this phenomenon among health care professionals

Tungaraza¹,

Talapan-Manikoth

Eboka³

et al. 2014

Int J Basic Clin Pharmacol

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Background: Slow release (SR) drug formulations associated with the passage of intact tablet like object in faeces sometimes known as the "ghost pill" have been in the market for many years. Anecdotal evidence suggests that few health care professionals are aware of this phenomenon. Our study aims were to find out what proportion of health care professionals was aware of the ghost pill phenomena and what drug formulations and specific drugs were associated with it. Methods: A survey was conducted among health care professionals at three hospital sights in the West Midlands, UK. The subjects included doctors, nursing staff, pharmacists, and other allied professionals involved in patient care. Results: A total of 321 health care professionals were included in the final analysis. Very few, 12.8% (41) have heard of the ghost pill phenomenon and a further 14 (4.4%) have come across of a patient who has experienced it. Only 13 (4%) correctly associated the phenomenon with SR drug formulations. Conclusion: Our survey has shown that the ghost pill phenomenon, a normal outcome of a novel way of delivering orally taken SR drugs, is not well-known among health care professionals. Lack of awareness of it has implications to trainers, medical and nonmedical prescribers and nursing staff working with patients who are taking these medications. Lack of awareness among health care staff, may result in relevant information not being shared with patients at the time of prescribing or when patients enquires of it.

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“…They are better distributed and less likely to cause local irritation. [7] Recently much emphasis is being laid on the development of Multiparticulate dosage forms in preference to single unit systems because of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying. [8] Reasons for formulating a drug as a Multiparticulate system are 1) to facilitate disintegration in the stomach, or 2) to provide a convenient, fast disintegrating tablet that dissolves in water before swallowing which can aid compliance in older patients and children.…”

mentioning

confidence: 99%

An Overview of Pelletization Techniques Used in Multiparticulate Drug Delivery System

Samreen¹

2017

WJPR

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Pharmaceutical research are increasingly focusing on new delivery systems which enhances desired therapeutic objective and therefore minimising side effects. The multiparticulate drug delivery systems are suitable for oral formulation to achieve controlled or delayed release. It has advantages like low dose dumping, flexibility of blending to attain different release pattern and for short gastric residence time. Therefore multiparticulate drug delivery system (MPDDS) provides opportunities in designing controlled and delayed release oral formulation. Pellets are defined as spherical/ semi-spherical, free flowing solid units with a narrow size distribution, typically in diameter between 0.5-2.0 mm.Pelletization technique is used to produce pellets. Pelletization techniques include Extrusion speronization, layering, Cryopelletization, freeze pelletization, spray congealing, spray drying and compression.Extrusion sheronization is widely used technique due to high efficiency and fast and simple processing.

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Coating of Multiparticulates for Sustained Release

Cited by 61 publications

References 103 publications

Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of Metoprolol Tartrate and Acetaminophen Extended Release Multiparticulates—Part I

Investigation into the Effect of Ethylcellulose Viscosity Variation on the Drug Release of Metoprolol Tartrate and Acetaminophen Extended Release Multiparticulates—Part I

Ghost pill: knowledge and awareness of this phenomenon among health care professionals

An Overview of Pelletization Techniques Used in Multiparticulate Drug Delivery System

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