Flexible piezoresistive sensors have been widely used in the fields of wearable electronic devices, electronic skin, intelligent human−computer interaction, health monitoring, life medicine research, intelligent robot, and so on. However, how to find a balance between stability, sensitivity, and sensing range, especially under the low-pressure range, is still an immediate challenge waiting to be solved. Herein, a highly flexible and compressible aerogel with a smooth layer structure was successfully fabricated by combining Ag nanowires into poly(3,4-ethylenedioxythiophene):polystyrene sulfonate and polyimide composites by casting and thermal annealing. As a result, the elastic aerogel with large reversible compressibility exhibited a good compression sensitivity of 0.31 kPa −1 in the pressure range of 0−1.25 kPa, high linearity of compression strain and resistance change rate, great fatigue resistance (height retention of 98−99% at 1000% strain/min), and large reversible compressibility (height retention of 90% after 200 compression cycles). The excellent performance of conductive aerogels shows their promising potential in the field of piezoelectric sensing.