Coating of Implants with Hydroxyapatite - Material Connections between Bone and Metal

Willmann, G.

doi:10.1002/(sici)1527-2648(199910)1:2<95::aid-adem95>3.0.co;2-p

Cited by 93 publications

(51 citation statements)

References 5 publications

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“…As metals do not undergo bone bonding, i.e., do not form a mechanically stable link between the implant and bone tissue, ways have been sought to improve contacts at the interface. The major way is to coat metals with calcium orthophosphate bioceramics that exhibit a bone-bonding ability between the metal and bone [194,205,339,525,[528][529][530][531][532][533]. Thickness of the coatings varies from submicron dimensions to several hundreds microns (Table 5) and this parameter appears to be very important.…”

Section: Coatingsmentioning

confidence: 99%

Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Section: Coatingsmentioning

confidence: 99%

Untitled

2011

BIO

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“…The basis for this is that the release of calcium and phosphate ions is increased at pH 6 as the solubility of calcium phosphates increases with decreasing pH. 56 Similarly, calcium and phosphate ions were released from the underlying calcium phosphate layer of alginate/chitosan/CaP layered coatings over a period of 3 days at pH 7.2. Decreasing the pH to 6.0 also led to additional release of calcium and phosphate ions in this structure ͑Fig.…”

Section: F Release Of Calcium and Phosphate Ionsmentioning

confidence: 99%

Concurrent elution of calcium phosphate and macromolecules from alginate/chitosan hydrogel coatings

et al. 2008

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The concurrent release of calcium phosphate and biomacromolecules may improve wound healing responses at the interface with ceramic materials of orthopaedic and dental implants. Hydrogel coatings consisting of a mixture of alginate and chitosan were doped and applied onto solid carriers with the aim of investigating their use as local delivery vehicles. Coatings containing both the model macromolecule FITC-dextran 70 kDa (FD 70) and dispersed calcium phosphate carbonate (CPC) nanoparticles were coated onto a solid, nonporous model substrate to study the concurrent release of FD 70 and calcium and phosphate ions from within the hydrogel. Hydrogel coatings containing only FD 70 were cast onto porous calcium phosphate coatings, similar to hydroxyapatite, to study the release of FD 70 from, and calcium and phosphate ions through, the hydrogel coating. Transmission electron microscopy showed good dispersion of the CPC nanoparticles, and scanning electron microscopy and atomic force microscopy showed that increased CPC loading resulted in an increase in surface roughness but to extents well below those affecting cell responses. The release of FD 70 from CPC-loaded coatings was similar to release from the hydrogel alone, although higher CPC loadings resulted in small changes. The release of FD 70 was better described by double or triple phase zero order release kinetics; this complex time dependence indicates that in addition to outdiffusion, other, time-dependent factors apply, such as swelling of the gel, as expected from the known effects of calcium ions on alginate. Calcium and phosphate ions were also released, with similar release kinetics, through the hydrogel layer from the underlying CaP layer. In either case, release decreased to negligible levels after 3 days, suggesting that the systems of this study are suitable for short-term concurrent release of water-soluble biomacromolecules and calcium and phosphate ions.

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“…[7] The most popular coating procedure is plasma spray. [7] Plasma-sprayed coatings are now commercially available, and numerous studies have shown that they enhance interfacial attachment to bone tissue over short periods of time, and promote the formation of a more reliable interface with bone than mechanical osseointegration. [7] However, the calcium phosphate coatings fabricated by plasma spray have severe drawbacks that include: (1) cracking and unreliable adhesion; (2) variability during processing in terms of resulting phases (typically, the coatings consist of a mixture of phases, some of them highly soluble amorphous calcium phosphates), morphology, thickness, and stresses; (3) significant degradation in the fatigue resistance and endurance strength of the implant alloy, and (4) inability to systematically change the coating attributes.…”

Section: Novel Coatingsmentioning

confidence: 99%

Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings

et al. 2005

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Metallic orthopaedic implants have been successfully used for decades but they have serious shortcomings related to their osseointegration and the fact that their mechanical properties do not match those of bone. This paper reviews recent advances in the fabrication of novel coatings to improve implant osseointegration and in the development of a new generation of hybrid organic-inorganic implant materials specifically designed for orthopaedic applications

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Coating of Implants with Hydroxyapatite - Material Connections between Bone and Metal

Cited by 93 publications

References 5 publications

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Concurrent elution of calcium phosphate and macromolecules from alginate/chitosan hydrogel coatings

Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings

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