Coating of an apatite layer on polyamide films containing sulfonic groups by a biomimetic process

Kawai, Takeshi; Ohtsuki, Chikara; Kamitakahara, Masanobu; Miyazaki, Toshiki; Tanihara, Masao; Sakaguchi, Yoshimitsu; Konagaya, Shigeji

doi:10.1016/j.biomaterials.2003.11.039

Cited by 147 publications

(94 citation statements)

References 15 publications

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“…It is reported that sulfonic groups (-SO 3 H) induce the heterogeneous nucleation of the apatite in body environment. 33,34) The sulfonyl groups in the divinylsulfone would also act as site of the heterogeneous apatite nucleation. Consequently, the increase in amount of the site of the apatite nucleation, e.g.…”

Section: Resultsmentioning

confidence: 99%

Effects of Cross-Linking Agent on Apatite-Forming Ability and Mechanical Property of Organic-Inorganic Hybrids Based on Starch

et al. 2007

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So-called bioactive ceramics can directly bond to living bone through the apatite layer formed on their surfaces in the body. However, hard and brittle character of ceramics limits their clinical applications to low loaded portions. The apatite deposition on the bioactive ceramics is known to be triggered by a catalytic effect of silanol (Si-OH) groups formed on their surfaces and by release of calcium ions (Ca 2þ ) that increases degree of supersaturation of the surrounding fluid with respect to the apatite. It is expected that organic modification of these components would produce bioactive materials with mechanical properties analogous to natural bone. We previously reported that bioactive organic-inorganic hybrids can be prepared from starch by modification with glycidoxypropyltrimethoxysilane (GPS) that provides with Si-OH groups and calcium chloride that releases calcium ions. In this study, we examined effect of synthetic conditions of the hybrids on their bioactivity and mechanical properties. We prepared several hybrids with different content of divinylsulfone as a cross-linking agent. Their bioactivity was examined in simulated body fluid (SBF, Kokubo solution) with inorganic ion concentrations nearly equal to those of human extracellular fluid. Materials that form the apatite on their surfaces in SBF are known to have a potential to show the bone-bonding. It was found that the added cross-linking agent did not decrease apatite-forming ability of the hybrids in SBF. Mechanical properties of the hybrids were further evaluated by a tensile test. Tensile strength and Young's modulus increased with increasing content of divinylsulfone.

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Section: Resultsmentioning

confidence: 99%

Effects of Cross-Linking Agent on Apatite-Forming Ability and Mechanical Property of Organic-Inorganic Hybrids Based on Starch

et al. 2007

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“…Films were produced either without or with calcium chloride added to the casting solution [54]. By the same method, Kawai et al prepared aromatic polyamide copolymers with a similar stoichiometric monomer ratio containing sulfonic groups (-SO 3 H) and using films produced with and without CaCl 2 [55].…”

Section: Resultsmentioning

confidence: 99%

Effect of Diazotated Sulphonated Polystyrene Films on the Calcium Oxalate Crystallization

et al. 2017

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Pathological crystallization of calcium oxalate (CaOx) inside the urinary tract is called calculi or kidney stone (Urolithiasis). CaOx exhibits three crystalline types in nature: CaOx monohydrate COM, dihydrate COD and trihydrate COT. COD and COM are often found in urinary calculi, particularly COM. Langmuir monolayers, membrane vesicles, phospholipids' micelles, among others, have been adopted as simplified biomimetic template-models to study in vitro the urolithiasis through CaOx. The nucleation and crystal growth of COM on self-assembled lipid monolayers have revealed that the negatively charged phosphatidylserine interface is a strong promoter of COM. Herein, we describe the synthesis and physicochemical characterization of diazotated sulphonated polystyrene films (DSPFs), prepared from various aminocompounds varying their polarity degree i.e., polar, non-polar and acidic DSPF derivatives. We also used these DSPFs as polymeric templates in crystallization experiments of CaOx in vitro. Images obtained by optical microscopy and scanning electron microscopy confirmed the precipitation of COM crystals on the DSPF surface. The employment of functionalized polymeric films as templates for CaOx crystallization represents a viable approach for understanding inorganic mineralization.

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“…33) Hence, specific functional groups on polymer substrate were found to induce heterogeneous nucleation of apatite in 1.5SBF, and hybridization of polymers with apatite was achieved. A similar idea proposed is the application of such an apatite coating on natural polymers such as silk fibers.…”

Section: Synthesis Of Functionalized Biomaterials Through Biomimetic mentioning

confidence: 99%

Development of highly functionalized ceramic biomaterials

Ohtsuki

2013

J. Ceram. Soc. Japan

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Ceramic biomaterials have been used clinically for repairing bony defects due to their biological affinity to living bone. Among ceramic biomaterials, bioactive ceramics directly bond to living bone. The bonding mechanism of bioactive ceramics to living bone provides a unique strategy in the development of novel biomaterials with high functionality. The mechanism of bonebonding has been clarified through observation of interfaces between artificial materials and living bones as well as investigation of structural changes of the materials in solutions mimicking in vivo conditions. A simulated body fluid (SBF) that has similar concentrations of inorganic ions has been used to estimate surface structural changes of implanted materials in bony defects. Bone-like apatite deposition on the surface of implants is an important event to achieve bone-bonding with bioactive ceramics. Thus, it is important to control the reaction of such materials with body fluid during the development of novel biomaterials. Based on a fundamental understanding of the reactions of ceramic materials in SBF, novel types of biomaterials have been designed, such as surface-modified titanium metal, organicinorganic hybrids, biomimetic composites, bioabsorbable materials, and calcium phosphates with designed morphology. In this review, the development of bioactive materials is described through a fundamental understanding of the calcification mechanisms of bioactive ceramics in SBF.

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Coating of an apatite layer on polyamide films containing sulfonic groups by a biomimetic process

Cited by 147 publications

References 15 publications

Effects of Cross-Linking Agent on Apatite-Forming Ability and Mechanical Property of Organic-Inorganic Hybrids Based on Starch

Effects of Cross-Linking Agent on Apatite-Forming Ability and Mechanical Property of Organic-Inorganic Hybrids Based on Starch

Effect of Diazotated Sulphonated Polystyrene Films on the Calcium Oxalate Crystallization

Development of highly functionalized ceramic biomaterials

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