2006
DOI: 10.1021/ac060066y
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Coated Wire Potentiometric Detection for Capillary Electrophoresis Studied Using Organic Amines, Drugs, and Biogenic Amines

Abstract: Capillary electrophoresis was coupled successfully and reliably to potentiometric sensors, which are based on an ionically conductive rubber phase coating, applied on a 250 microm diameter metal substrate. The membrane components included potassium tetrakis(p-chlorophenyl)borate (TCPB), bis(2-ethylhexyl)sebacate (DOS), and high molecular mass poly(vinyl chloride) (PVC). Potentiometry reveals a very sensitive CE detection mode, with sub-micromolar detection limits for amines and the randomly chosen drugs quinin… Show more

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Cited by 48 publications
(47 citation statements)
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“…The first report about CE coupled with potentiometric detection dates from 1996 [117] and little research has been performed in this field over the past 10 years [118]. In the last two years, to our knowledge, only one paper has reported potentiometric detection with CE [119], in which the coated wire systems had a classical ionically conductive rubber composition as coating. That system gave submicromolar detection limits for amines and the randomly chosen drugs quinine, clozapine, cocaine, heroin, noscapine, papaverine, and ritodrine.…”
Section: Potentiometric Detectionmentioning
confidence: 99%
“…The first report about CE coupled with potentiometric detection dates from 1996 [117] and little research has been performed in this field over the past 10 years [118]. In the last two years, to our knowledge, only one paper has reported potentiometric detection with CE [119], in which the coated wire systems had a classical ionically conductive rubber composition as coating. That system gave submicromolar detection limits for amines and the randomly chosen drugs quinine, clozapine, cocaine, heroin, noscapine, papaverine, and ritodrine.…”
Section: Potentiometric Detectionmentioning
confidence: 99%
“…If a membrane contains an ion of charge opposite to the analyte ions, instead of a ionophore, then the selectivity is simply governed by the lipophilicity of the analyte ions, which in turn is related to their hydration energies [12]. Such electrodes, termed Hofmeister electrodes, have been employed for detection of inorganic cations [13][14][15] and anions [14,16,17], but as the highest response is obtained for the more lipophilic ions it works best for organic ions [18][19][20]. This is illustrated in Fig.…”
Section: Potentiometrymentioning
confidence: 99%
“…Consequently in analogous static conditions where c analyte s Cst, the response becomes constant and independent of c analyte , thus LOD of the batch potentiometric system should be reached. However, to obtain concentration-related signals in the nonstatic, hydrodynamic conditions as the recorded HPLC chromatograms, the potentiometric detector's output E(mV) was transformed via an earlier described function enabling delogarithmization of measured potential DE values [21,40,41], i.e., transpose of the Nicolskii-Eisenmann equation as shown in Eq. (2):…”
Section: Statistical Analysis and Data Treatmentmentioning
confidence: 99%
“…This transformation is valid in hydrodynamic conditions of each chromatographic system, where we can put the detector output E(mV) equal to zero for c analyte = 0, i.e., at the baseline of the chromatographic tracing [21,40,41]. Each tracing was transformed using the following formula, which yields a concentration-related signal:…”
Section: Statistical Analysis and Data Treatmentmentioning
confidence: 99%
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