Coated microneedles for transdermal delivery

Gill, Harvinder Singh; Prausnitz, Mark R.

doi:10.1016/j.jconrel.2006.10.017

Cited by 598 publications

(470 citation statements)

References 27 publications

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“…Using methods described in detail previously [4], microneedles were cut into 75 μm thick stainless steel sheets (Trinity Brand Industries, SS 304; McMaster-Carr, Atlanta, GA, USA) using an infrared laser (Resonetics Maestro, Nashua, NH, USA). Holes through microneedle shafts to form "pockets" were similarly cut.…”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

“…Single microneedles, and arrays of multiple microneedles, were coated using a micron-scale dip-coating process developed previously [4]. Coatings were formed by dipping the microneedle into a coating solution once, unless otherwise noted.…”

Section: Micron-scale Dip-coatingmentioning

confidence: 99%

“…Robust coating methods have been developed for this approach [4] and in vivo delivery of ovalbumin as a model vaccine has been studied in detail [5].…”

Section: Introductionmentioning

confidence: 99%

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Pocketed microneedles for drug delivery to the skin

Gill¹,

Prausnitz²

2008

Journal of Physics and Chemistry of Solids

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Drug delivery to the skin is limited by the strong barrier properties of skin's outer layer of stratum corneum. Micron-scale needles have been developed to deliver drugs across this barrier layer and into the skin in a minimally invasive manner. One method of delivery involves coating these microneedles with a drug that rapidly dissolves off within the skin. As a variation on this approach, this study examines microneedles with holes cut through their shafts to form "pockets" that can be filled with drug formulations using a dip-coating method. Our results (i) demonstrated the filling of microneedle pockets having a variety of different sizes and shapes, (ii) quantified the amount of drug that can be filled into pockets and coated onto microneedle surfaces, (iii) developed composite microneedle structures that sequester one model drug within the microneedle pocket and coat another model drug on the microneedle surface and (iv) showed that pocketed microneedles can deliver a model drug to a targeted depth within the skin. We conclude that pocketed microneedles offer unique capabilities for controlled drug delivery to the skin.

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Section: Fabrication Of Microneedlesmentioning

confidence: 99%

Section: Micron-scale Dip-coatingmentioning

confidence: 99%

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Pocketed microneedles for drug delivery to the skin

Gill¹,

Prausnitz²

2008

Journal of Physics and Chemistry of Solids

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“…But, it has a number of disadvantages associated with it. Hypodermic needles often cause pain, transmit pathogens through needle re-use and require medical expertise to use (Gill and Prausnitz, 2007). Transdermal drug delivery is both painless and user-friendly.…”

Section: Introductionmentioning

confidence: 99%

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Davidson

Al-Qallaf

Das

2008

Chemical Engineering Research and Design

140

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can potentially allow the transdermal delivery of many medicaments including large macromolecules that typically cannot diffuse through the skin. This paper addresses the use of microneedles coated with a drug solution film. In particular, we identify how the geometries of various microneedles affect the drug permeability in skin. Effective skin permeability is calculated for a range of microneedle shapes and dimensions in order to identify the most 20 efficient geometry. To calculate effective permeability (P eff ), the effective skin thickness (H eff ) is calculated. These are then plotted for insulin as a model drug to see how various microneedle parameters affect the profiles of both H eff and P eff . It is found that the depth of penetration from the microneedle array is the most important factor in determining P eff , followed by the microneedle spacings. Other parameters such as microneedle diameter and 25 coating depth are less significant.

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“…Many microneedle systems (e.g. coated 41 , dissolvable 42 , swellable 43 ) incorporate the drug into the device in a solid-state, extending the shelf-life compared to drug solutions in syringes 44 . Post-insertion, these needles are no longer sharp 42,43 , thus preventing reuse, needle-stick injury as well as reducing waste management issues.…”

Section: Evolution To Microneedle Drug Delivery Patchesmentioning

confidence: 99%

Toward Biofunctional Microneedles for Stimulus Responsive Drug Delivery

Cahill

O’Cearbhaill

2015

Bioconjugate Chem.

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Microneedles have recently been adopted for use as a painless and safe method of transdermal therapeutic delivery through physically permeating the stratum corneum. While microneedles create pathways to introduce drugs, they can also act as conduits for biosignal sensing. Here, we explore the development of microneedles as both biosensing and drug delivery platforms. Microneedle sensors are being developed for continuous monitoring of biopotentials and bioanalytes through the use of conductive and electrochemically reactive biomaterials. The range of therapeutics being delivered through microneedle devices has diversified, while novel bioabsorbable microneedles are undergoing first-in-human clinical studies. We foresee that future microneedle platform development will focus on the incorporation of biofunctional materials, designed to deliver therapeutics in a stimulus responsive fashion. Biofunctional microneedle patches will require improved methods of attaching to and conforming to epithelial tissues in dynamic environments for longer periods of time and thus present an assortment of new design challenges. Through the evolution of biomaterial development and microneedle design, biofunctional microneedles are proposed as a next generation of stimulus responsive drug delivery systems.

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Coated microneedles for transdermal delivery

Cited by 598 publications

References 27 publications

Pocketed microneedles for drug delivery to the skin

Pocketed microneedles for drug delivery to the skin

Transdermal drug delivery by coated microneedles: Geometry effects on effective skin thickness and drug permeability

Toward Biofunctional Microneedles for Stimulus Responsive Drug Delivery

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