Coated Microneedles for Drug Delivery to the Eye

Jiang, Jason; Gill, Harvinder Singh; Ghate, Deepta; McCarey, Bernard E.; Patel, Samir R.; Edelhauser, Henry F.; Prausnitz, Mark R.

doi:10.1167/iovs.07-0066

Cited by 210 publications

(122 citation statements)

References 15 publications

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“…Docetaxel [73] Poke and patch Administration in form of liposomes increases the bioavailability and reduces lag time. Pilocarpine [74] Coat and poke Rapid and extensive pupil constriction with higher bioavailability. Riboflavin [75] Coat and poke Studied various parameters of coating of riboflavin on microneedles.…”

Section: Drugsmentioning

confidence: 99%

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2011

Journal of Pharmacy and Pharmacology

342

207

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Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings. Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area. Key findings Microneedles are fabricated using a microelectromechanical system employing silicon, metals, polymers or polysaccharides. Solid coated microneedles can be used to pierce the superficial skin layer followed by delivery of the drug. Advances in microneedle research led to development of dissolvable/degradable and hollow microneedles to deliver drugs at a higher dose and to engineer drug release. Iontophoresis, sonophoresis and electrophoresis can be used to modify drug delivery when used in concern with hollow microneedles. Microneedles can be used to deliver macromolecules such as insulin, growth hormones, immunobiologicals, proteins and peptides. Microneedles containing 'cosmeceuticals' are currently available to treat acne, pigmentation, scars and wrinkles, as well as for skin tone improvement. Summary Literature survey and patents filled revealed that microneedle-based drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional transdermal techniques.

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Section: Drugsmentioning

confidence: 99%

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2011

Journal of Pharmacy and Pharmacology

342

207

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“…27 The transient pores created by microneedles and diffusion of the protein through the polymeric layer to the epidermal and dermal regions to create a depot of protein drugs have been implicated. 10,53 The drugs can be subsequently absorbed into the blood stream or lymphatic circulation. 11,54 It is expected that the protein released will accumulate in the subepidermal tissues and be rapidly absorbed from the highly vascularized regions lying underneath.…”

Section: In Vitro Release Of Bsa From Microneedlesmentioning

confidence: 99%

“…9 Drugs have been delivered using microneedles by three different modes. Firstly, coating onto microneedle shafts, 10,11 and secondly, pretreating the skin with microneedles to create pores, followed by application of conventional dosage forms. 12,13 With the development of polymeric microneedles, a third approach was developed whereby drugs could be encapsulated in the polymeric matrix and released from the polymer upon application.…”

Section: Introductionmentioning

confidence: 99%

Protein encapsulation in polymeric microneedles by photolithography

Kochhar¹,

Zou²,

Chan³

et al. 2012

IJN

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Background: Recent interest in biocompatible polymeric microneedles for the delivery of biomolecules has propelled considerable interest in fabrication of microneedles. It is important that the fabrication process is feasible for drug encapsulation and compatible with the stability of the drug in question. Moreover, drug encapsulation may offer the advantage of higher drug loading compared with other technologies, such as drug coating. Methods and results:In this study, we encapsulated a model protein drug, namely, bovine serum albumin, in polymeric microneedles by photolithography. Drug distribution within the microneedle array was found to be uniform. The encapsulated protein retained its primary, secondary, and tertiary structural characteristics. In vitro release of the encapsulated protein showed that almost all of the drug was released into phosphate buffered saline within 6 hours. The in vitro permeation profile of encapsulated bovine serum albumin through rat skin was also tested and shown to resemble the in vitro release profile, with an initial release burst followed by a slow release phase. The cytotoxicity of the microneedles without bovine serum albumin was tested in three different cell lines. High cell viabilities were observed, demonstrating the innocuous nature of the microneedles. Conclusion:The microneedle array can potentially serve as a useful drug carrier for proteins, peptides, and vaccines.

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“…Hollow microneedles are used for intrascleral and suprachoroidal delivery of a sustained-release drug depot in a tissue layer, with clearance mechanisms that are minimal or less than those in the subconjunctival or sub-Tenon's space. Microneedles allow for better retinochoroidal targeting than periocular drug delivery, because it is closer to the target tissue (Jiang, Gill, Ghate, et al 2007;Jiang, Moore, Edelhauser, et al 2009). A hollow microcatheter cannulation drug delivery technique has also been developed for suprachoroidal drug delivery.…”

Section: Hybrid Drug Delivery In Amdmentioning

confidence: 99%