Coated biodegradable casein nanospheres: a valuable tool for oral drug delivery

Spizzirri, Umile Gianfranco; Cirillo, Giuseppe; Curcio, Manuela; Spataro, Tania; Picci, Nevio; Iemma, Francesca

doi:10.3109/03639045.2015.1040415

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…29,30 It has been grafted on biocompatible materials which were used as drug carriers frequently. [31][32][33] In acidic conditions, PAA is likely to protonate to be relatively hydrophobic; on the contrary, it will deprotonate in neutral or alkaline conditions to be hydrophilic. Therefore, its solubility becomes poor and even collapses entangled together to precipitate with the decrease of pH.…”

Section: Introductionmentioning

confidence: 99%

pH-triggered sustained release of arsenic trioxide by polyacrylic acid capped mesoporous silica nanoparticles for solid tumor treatment in vitro and in vivo

et al. 2016

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Arsenic trioxide (As2O3, ATO), a FDA approved drug for hematologic malignancies, was proved of efficient growth inhibition of cancer cell in vitro or solid tumor in vivo. However, its effect on solid tumor in vivo was hampered by its poor pharmacokinetics and dose-limited toxicity. In this study, a polyacrylic acid capped pH-triggered mesoporous silica nanoparticles was conducted to improve the pharmacokinetics and enhance the antitumor effect of arsenic trioxide. The mesoporous silica nanoparticles loaded with arsenic trioxide was grafted with polyacrylic acid (PAA-ATO-MSN) as a pH-responsive biomaterial on the surface to achieve the release of drug in acidic microenvironment of tumor, instead of burst release action in circulation. The nanoparticles were characterized with uniform grain size (particle sizes of 158.6 ± 1.3 nm and pore sizes of 3.71 nm, respectively), historically comparable drug loading efficiency (11.42 ± 1.75%), pH-responsive and strengthened sustained release features. The cell toxicity of amino groups modified mesoporous silica nanoparticles (NH2-MSN) was significantly reduced by capping of polyacrylic acid. In pharmacokinetic studies, the half time (t1/2β) was prolonged by 1.3 times, and the area under curve) was increased by 2.6 times in PAA-ATO-MSN group compared with free arsenic trioxide group. Subsequently, the antitumor efficacy in vitro (SMMC-7721 cell line) and in vivo (H22 xenografts) was remarkably enhanced indicated that PAA-ATO-MSN improved the antitumor effect of the drug. These results suggest that the polyacrylic acid capped mesoporous silica nanoparticles (PAA-MSN) will be a promising nanocarrier for improving pharmacokinetic features and enhancing the anti-tumor efficacy of arsenic trioxide.

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Section: Introductionmentioning

confidence: 99%

pH-triggered sustained release of arsenic trioxide by polyacrylic acid capped mesoporous silica nanoparticles for solid tumor treatment in vitro and in vivo

et al. 2016

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Casein-based hydrogels: A mini-review

et al. 2020

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Recent trends on hydrogel based drug delivery systems for infectious diseases

et al. 2016

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For centuries, the rapid spread and cure of infectious diseases have been a major concern to the progress and survival of humans. These diseases are the global burden and the prominent cause for the worldwide deaths and disability. Nanomedicine has emerged as the most excellent tool to eradicate and halt their spread. Various nanoformulations (NFs) using advanced nanotechnology are in demand. Recently, hydrogel and nanogel based drug delivery devices poses new prospects to simulate the natural intelligence of various biological systems. Owing to their unique porous interpenetrating network design, hydrophobic drug incorporation and stimulus sensitivity hydrogels owe excellent potential as targeted drug delivery system. Present review is an attempt to highlight the recent trends of hydrogel based drug delivery systems for the delivery of therapeutic agents and diagnostics for the major infectious diseases including Acquired immune deficiency syndrome (AIDS), Malaria, Tuberculosis, Influenza and Ebola. Future prospective and challenges are also briefed.

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Coated biodegradable casein nanospheres: a valuable tool for oral drug delivery

Cited by 6 publications

References 42 publications

pH-triggered sustained release of arsenic trioxide by polyacrylic acid capped mesoporous silica nanoparticles for solid tumor treatment in vitro and in vivo

pH-triggered sustained release of arsenic trioxide by polyacrylic acid capped mesoporous silica nanoparticles for solid tumor treatment in vitro and in vivo

Casein-based hydrogels: A mini-review

Recent trends on hydrogel based drug delivery systems for infectious diseases

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