Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

Cadieu, Édouard; Neff, Mark W.; Quignon, Pascale; Walsh, Kari F.; Chase, Kevin; Parker, Heidi G.; vonHoldt, Bridgett M.; Rhue, Alison; Boyko, Adam B.; Byers, Alexandra M.; Wong, Aaron K.; Mosher, Dana S.; Elkahloun, Abdel G.; Spady, Tyrone C.; André, Catherine; Lark, Gordon K.; Cargill, Michelle; Bustamante, Carlos D.; Wayne, Robert K.; Ostrander, Elaine A.

doi:10.1126/science.1177808

Cited by 294 publications

(334 citation statements)

References 24 publications

(21 reference statements)

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“…The LUPA database, already containing genotypes from 10,000 dogs, can be used to perform GWAS across breeds, with the aim to identify variants underlying traits shared by several breeds, as has already been documented in other studies (Jones et al, 2008;Cadieu et al, 2009;Akey et al, 2010;Bannasch et al, 2010;Boyko et al, 2010). An alternative approach searches for selective sweeps: regions with reduced heterozygosity associated with a specific trait within a single or within a group of breeds that share the same trait (A. Vaysse personal communication).…”

Section: Detecting Signatures Of Selectionmentioning

confidence: 99%

LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

Lequarré

Andersson

André

et al. 2011

The Veterinary Journal

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a b s t r a c tThe domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.

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Section: Detecting Signatures Of Selectionmentioning

confidence: 99%

LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

Lequarré

Andersson

André

et al. 2011

The Veterinary Journal

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“…CFA 18 that is responsible for the characteristic short-limb phenotype in Daschshunds and other breeds (8), and three genes (RSPO2, FGF5, and KRT71) that influence coat phenotypes in many breeds (9). Second, we performed extensive coalescent simulations that take into account SNP ascertainment and major demographic features, such as population structure and breed-specific bottlenecks.…”

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confidence: 99%

Tracking footprints of artificial selection in the dog genome

Akey

Ruhe

Akey

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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The size, shape, and behavior of the modern domesticated dog has been sculpted by artificial selection for at least 14,000 years. The genetic substrates of selective breeding, however, remain largely unknown. Here, we describe a genome-wide scan for selection in 275 dogs from 10 phenotypically diverse breeds that were genotyped for over 21,000 autosomal SNPs. We identified 155 genomic regions that possess strong signatures of recent selection and contain candidate genes for phenotypes that vary most conspicuously among breeds, including size, coat color and texture, behavior, skeletal morphology, and physiology. In addition, we demonstrate a significant association between HAS2 and skin wrinkling in the Shar-Pei, and provide evidence that regulatory evolution has played a prominent role in the phenotypic diversification of modern dog breeds. Our results provide a first-generation map of selection in the dog, illustrate how such maps can rapidly inform the genetic basis of canine phenotypic variation, and provide a framework for delineating the mechanistic basis of how artificial selection promotes rapid and pronounced phenotypic evolution.

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“…The morphological analysis of hairs is also a valuable method of identification used in forensic sciences (14,21). Numerous papers concerning veterinary aspects of dogs' hair coat (3,5,10,11,16,20), influence of nutrition on coat quality and health status of skin (17,19), histological aspects of hair cycle in dogs (1), or coat differentiation depending on genotype (2,15) are available in the literature. The breed standard for dachshund has been also elaborated, including general coat characteristics (8); however, there is a lack of studies analysing in a complex manner the histological structure of hair coat of different breeds and varieties of dogs.…”

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confidence: 99%

Analysis of Hair Coat of Dachshund of Longhaired, Shorthaired, and Wirehaired Variety

Czyż

Patkowska-Sokoła

Filistowicz

et al. 2012

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to analyse the hair coat of the three dachshund varieties, i.e. shorthaired, longhaired, and wirehaired, with respect to its histological structure and content of selected chemical elements. The study was conducted on female dachshunds originating from individual breeders. The study included the assessment of the contribution of particular hair fractions, measurements of hair thickness and length, and also the analysis of histological structure of particular hair fractions. A great differentiation in the parameters and structure of particular kinds of hair from the examined dogs was demonstrated. Thickness and length of hair of particular varieties showed statistically significant differentiation, as well as percentage contribution of particular hair fractions. As regard the content of chemical elements in particular hair fractions and dachshund variety, it appeared that the elements forming hair keratin were the most abundant. The findings presented in the paper may be a useful tool for the recognition of dachshund varieties based on their hair coat structure. They may be also a valuable contribution to the expanding breed standards, which lack histological hair description.

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Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes

Cited by 294 publications

References 24 publications

LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

LUPA: A European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs

Tracking footprints of artificial selection in the dog genome

Analysis of Hair Coat of Dachshund of Longhaired, Shorthaired, and Wirehaired Variety

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