Coarse-grained methods for heterogeneous vesicles with phase-separated domains: Elastic mechanics of shape fluctuations, plate compression, and channel insertion

Rower, David A.; Atzberger, Paul J.

doi:10.1016/j.matcom.2023.02.020

Cited by 1 publication

(2 citation statements)

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“…When the two molecules are immiscible and tend to phase separate, one might observe domain‐dependent behaviors as drawn in Figure 3F. The emergent curvature can be controlled by the intrinsic repulsion between the two components, the composition ratios of the two molecules, as well as other environmental conditions that affect the interaction between the molecules and the solvent 49–51 …”

Section: Theories and Experiments Of Shape‐changing Behaviors Of Self...mentioning

confidence: 99%

“…The emergent curvature can be controlled by the intrinsic repulsion between the two components, the composition ratios of the two molecules, as well as other environmental conditions that affect the interaction between the molecules and the solvent. [49][50][51] Specifically for the bilayer structures, curvature can be driven by asymmetric properties in the two leaflets. 37,39 In fact, a perfectly symmetric bilayer is extremely exceptional, and often only serves as a minimal model for understanding basic physics.…”

Section: Principles Of Shape Controlmentioning

confidence: 99%

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Simulations of morphology control of self‐assembled amphiphilic surfactants

Zhu

Tree

2023

Journal of Polymer Science

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One of the grand challenges of amphiphilic self‐assembly is the design of ordered structures whose morphology or shape can be explicitly and dynamically controlled by adjusting the properties of the amphiphiles or their surroundings. Such a capacity would enable researchers to create synthetic systems with functionality that meets or exceeds biological cells, and provide a robust platform for a broad range of engineering applications such as artificial tissues, drug delivery, and separation membranes. Despite significant progress, important fundamental questions remain unanswered, due in part to the limited resolution and the restricted parameter spaces that are readily accessible in experiments. Computational studies thus provide an important complement to experiments, enabling in‐depth insight into underlying mechanisms and an exploration of the parameter spaces for behavior that has not yet been achieved in experiments. In this review, we briefly introduce fundamental concepts and pertinent experiments related to dynamic shape modulation in self‐assembled amphiphiles. Then, in the bulk of the review, we survey the most influential simulation studies that investigate and identify approaches to control the self‐assembled shape of amphiphiles, with an emphasis on kinetic and mechanical effects. Finally, we conclude with a perspective on future research directions in this exciting field.

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Section: Theories and Experiments Of Shape‐changing Behaviors Of Self...mentioning

confidence: 99%