Coal Workers' Pneumoconiosis

Morgan, William J.; Andrews, Charles E.

doi:10.1126/science.176.4032.231

Cited by 3 publications

(2 citation statements)

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“…Many factors, such as rank of coal, method of mining, geographic location, and concentrations of minerals in the coal mine dust, have been shown to play a part in the prevalence, severity, and type of disease. In addition, other unknown factors or partially characterized factors are also probably important in the pathogenesis of coal workers' pneumoconiosis (80,81).…”

Section: Coamentioning

confidence: 99%

The Role of Oxygen Free Radicals in Occupational and Environmental Lung Diseases

Vallyathan¹,

Shi²

1997

Environmental Health Perspectives

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Oxygen free radicals and their metabolites, collectively described as reactive oxygen species (ROS), have been implicated in the pathogenesis of many diseases. The pulmonary system is particularly vulnerable to ROS-induced injury because of its continuous exposure to toxic pollutants from a wide variety of sources in the ambient air. Additionally, lungs are exposed systemically to ROS generated from xenobiotic compounds and endogenous sources. This review describes the sources of endogenous and exogenous ROS generation in the lung. Special emphasis is given to major sources of ROS in occupational and environmental exposures to asbestos, crystalline silica, coal, chromium, herbicides, bleomycin, and cigarette smoke. ROS-induced lung injury at different target levels may contribute to similar patterns of cell injury and alterations at the molecular level by initiation, propagation, and autocatalytic chain reactions. Intracellular signalling, activation and inactivation of enzymes, stimulation, secretion, and release of proinflammatory cytokines, chemokines, and nuclear factor activation and alterations are also common events. Understanding the interactions of these intricate mechanistic events is important in the prevention and amelioration of lung injury that results from acute and chronic exposures to toxins in ambient air. Environ Health Perspect 1 05(Suppl 1 :1 65-177 (1997)

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Section: Coamentioning

confidence: 99%

The Role of Oxygen Free Radicals in Occupational and Environmental Lung Diseases

Vallyathan¹,

Shi²

1997

Environmental Health Perspectives

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“…Evidence of cor pulmonale was noted on postmortem examination of coal miners [Rasmussen et al, 1968;Naeye and Dellinger, 1970;Naeye and Laquer, 1970;Naeye, 1971;Naeye and Dellinger, 19721, in pathological descriptions of silicotic men [Gross, 19631, and following inhalation studies in rabbits [Schepers, 19591. Recent texts on occupational lung disease include cor pulmonale among the classic complications or end-stage outcomes of the pneumoconioses [Morgan and Seaton, 1984;Parkes, 1982;Merchant, 1986;Rom, 19831, and pneumoconiosis is included among the pathogenetic mechanisms for chronic pulmonary hypertension and cor pulmonale [Fishman, 19871. However, to put this in perspective, Morgan [1984] has pointed out that findings such as those of Rasmussen et al [1968] have been dismissed [Stanescu, 19691, and emphasized that it is generally accepted that simple coal workers' pneumoconiosis seldom leads to right ventricular hypertrophy. More recently, Fernie et al [1983] found that the prevalence of right ventricular hypertrophy (RVH) at autopsy was not increased among coal miners with simple pneumoconiosis but that it appeared to be related to emphysema.…”

Section: Introductionmentioning

confidence: 96%

Cor pulmonale and pneumoconiotic lung disease: An investigation using hospital discharge data

Kusiak

Liss

Gailitis

1993

American J Industrial Med

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Cor pulmonale has been reported in the past to be associated with pneumoconiosis as an end-stage complication. However, whether the association can be demonstrated among cases of pneumoconiosis acquired in more recent decades is not clear. We examined the relation between these conditions using data summarized in hospital records in Ontario for males discharged between 1979 and 1990 with a diagnosis of chronic cor pulmonale or one of the pneumoconioses. Based on the age-specific frequency rates, cor pulmonale was diagnosed 17 (95% confidence interval 13-22) times more frequently than expected among men diagnosed with pneumoconiosis than among other men admitted to hospital. Our investigation indicates that cor pulmonale still appears to be associated with dust exposure in the workplace, and it demonstrates the usefulness of hospital discharge information in addressing questions in occupational health. However, we recommend that hospital medical records be examined to confirm the diagnoses and to determine the smoking histories of these men.

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Effect of coal rank on the interferon system

Hahon

1983

Environmental Research

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Coal Workers' Pneumoconiosis

Cited by 3 publications

References 1 publication

The Role of Oxygen Free Radicals in Occupational and Environmental Lung Diseases

The Role of Oxygen Free Radicals in Occupational and Environmental Lung Diseases

Cor pulmonale and pneumoconiotic lung disease: An investigation using hospital discharge data

Effect of coal rank on the interferon system

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