Coal Worker’s Pneumoconiosis

Verschakelen, Johny; Gevenois, Pierre Alain

doi:10.1007/3-540-30903-9_12

Cited by 1 publication

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not find a significant relationship between the perfusion score and pulmonary function parameters, or the percent of emphysema. Similar results have been reported in several previous studies [16,19,30,31]. Gevenois et al suggest that the presence of micronodules in coal miners has no effect on lung function, and that it should only be considered as a marker of exposure [19].…”

Section: Discussionsupporting

confidence: 86%

Emphysema and Airflow Obstruction in Non-Smoking Coal Miners with Pneumoconiosis

et al. 2016

View full text Add to dashboard Cite

BackgroundAccumulating evidence shows that functional impairment in subjects with coal workers’ pneumoconiosis (CWP) is principally due to emphysema and airflow obstruction, rather than underlying restrictive mechanisms. However, cigarette smoking has remained a major confounder. The aim of this study was to assess whether coal dust exposure was associated with emphysema and/or airflow obstruction in the absence of smoking history.Material/MethodThe subjects evaluated for possible pneumoconiosis between 2013 and 2015 were retrospectively enrolled into this study. After excluding those with history of smoking, tuberculosis, or lung cancer, the study population was a total of 57 subjects. The emphysema severity and airflow obstruction were quantified by computed tomographic densitometry analysis and spirometry, respectively. For comparability regarding emphysema, 9 age- and sex-matched nonsmoker (n=9) control subjects without known lung disease were randomly selected from a radiology database.ResultsEmphysema severity was significantly higher in the CWP group compared with the control group (15% vs. 4%, p<0.001). The median percent emphysema and percentage of those with FEV1/FVC <0.7 was 13% and 37% in subjects with simple CWP and 18% and 67% in subjects with complicated CWP, respectively. Percent emphysema and Perc15 (15th percentile of the attenuation curve) was correlated with FEV1/FVC (r=−0.45, r=−0.47) and FEF25–75 (r=−0.36, r=−0.56), respectively, but not with perfusion score. A linear regression analysis showed that factors associated with emphysema were FEV1/FVC (β=−0.24, p=0.009) and large opacity (β=−3.97, p=0.079), and factors associated with FEV1/FVC were percent emphysema (β=−0.51, p=0.018) and tenure (β=−0.63, p=0.044).ConclusionsOur results support the observation that coal dust exposure is associated with emphysema and airflow obstruction, independent of smoking status.

show abstract