Coal Dust Contiguity-induced Changes in the Concentration of TNF-α and NF-κ B p65 on the Ocular Surface

Sun, Zhaoyi; Hong, Jing; Liu, Zaiying; Jin, Xu; Gu, Changhong

doi:10.1080/09273940802650380

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…Researchers also found the single protein lysozyme test to be insufficient for the diagnosis of dry eye [ 95 ]. Nevertheless, lysozyme levels may be useful in specific contexts, for example, to check for adverse effects of beta-adrenergic receptor blocking drugs such as Practalol, which reduced tear lysozyme levels [ 96 ] or to detect dry eye from specific occupational exposures in coal mining [ 97 ]. With so many existing and emerging technologies, it may be worthwhile to take a fresh look at the utility of lysozyme.…”

Section: Reviewmentioning

confidence: 99%

Practical issues concerning tear protein assays in dry eye

D’Souza

Tong

2014

Eye and Vis

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Dry eye is a common clinical condition diagnosed by cumulative evidence of symptoms and signs. Many new treatments in dry eye are either expensive, invasive, have potential for side effects, or are not easily accessible. In severe dry eye, the ideal modality of treatment to begin with is often not clear as specific molecular disturbances are not evident from just examination of clinical manifestations. Assessing the effects of ongoing treatment is not straight forward since there is lack of agreement between clinical signs and symptoms. There is a need to have more objective methods of selecting treatment for dry eye and monitoring the effect of treatment.Recently, there are many new technologies applied to the discovery of tear biomarkers, for e.g., mass spectrometry based proteomics techniques and multiplex assays such as the bead-based sandwich indirect immunofluorescent assays. Tear proteins assays have even been made available as point-of-care devices. This review focuses on the evidence for the involvements of tear proteins in dry eye, possible changes in tear concentrations with therapy and the strength of evidence regarding dry eye pathology. Much remains to be done in terms of developing office-based assays and ascertaining their reliability, but current evidence suggests that tear proteins have a role in the clinical practice of dry eye.

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Section: Reviewmentioning

confidence: 99%

Practical issues concerning tear protein assays in dry eye

D’Souza

Tong

2014

Eye and Vis

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“…biomarker ini dapat berguna untuk memantau efek samping dari obat penghambat reseptor beta adrenergik seperti Practalol atau untuk mendeteksi mata kering akibat paparan pada pekerjaan tertentu seperti di pertambangan batu bara. [5,16,19] Laktoferin dan lisozim adalah produk utama kelenjar lakrimal. Penurunan kadar kedua protein tersebut dikaitkan dengan disfungsi kelenjar lakrimal, kerusakan permukaan mata, reaksi inflamasi, kapasitas antioksidan yang rendah, dan aktivitas antimikroba yang rendah (terutama lisozim).…”

Section: Biomarker Air Mata Pada Penyakit Mata Kering 231 Biomarker Proteinunclassified

Analisis Berbagai Macam Biomarker Air Mata dalam Diagnosis Penyakit Mata Kering

Furqan¹,

Sidhi²,

Amsari³

2020

JIMKI

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Pendahuluan: Diagnosis penyakit mata kering (Dry Eye Disease/ DED) terutama pada tahap awal merupakan hal yang penting, tetapi seringkali sulit. Hal ini dikarenakan kurangnya standar emas dan korelasi yang buruk antara perubahan biokimia air mata dan tanda-tanda klinis. Biomarker air mata dinilai dapat digunakan dalam diagnosis dan memantau DED karena bersifat non invasive, serta memiliki korelasi yang baik dengan perubahan biokimia air mata dan perkembangan penyakit. Tujuan: Artikel ini akan memaparkan beberapa biomarker air mata yang paling penting untuk DED yaitu marker untuk disfungsi kelenjar lakrimal, inflamasi, stres oksidatif, dan intoleransi lensa kontak, serta korelasinya dengan subtipe dan keparahan penyakit. Metode: Metode yang digunakan adalah studi pustaka dengan menggunakan jurnal 10 tahun terakhir yang diperoleh dari mesin pencarian seperti Sciencedirect, PubMed, Google Scholar dan ClinicalKey. Pembahasan: Biomarker untuk disfungsi kelenjar lakrimal ditandai dengan perubahan kadar protein (laktoferin, lisozim, dll), neuromediator (NGF, CGRP, NPY, Serotonin), dan mucin ((MUC)5AC); sementara respons inflamasi ditandai dengan perubahan ekspresi sitokin, kemokin, MMP-9, dan albumin. Stres oksidatif ditandai dengan perubahan kadar lipid (HNE, MDA). Sementara itu intoleransi lensa kontak dihubungkan dengan perubahan secretoglobin 1D1, β2 microglobulin, lacritin, secretoglobin 1A2, albumin, LPRR4, LCN-1, dan PIP. Kesimpulan: MMP-9 dan kombinasi Mammaglobin B, lipophilin A, dan B2MG merupakan biomarker dengan sensitivitas dan spesifitas tertinggi dari biomarker lainnya. Beberapa biomarker tersebut dapat digunakan untuk mendiagnosis DED, membedakan antara sindrom Sjögren DED dan sindrom non-Sjögren DED, ADDE dari EDE, serta menentukan tingkat keparahan penyakit.

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Respirable nano-particulate generations and their pathogenesis in mining workplaces: a review

Fan

Liu

2021

Int J Coal Sci Technol

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There is a growing concern in mining community about the contribution of nano-particulates to miner’s health. Despite the health influence of respirable dusts and associated lung diseases have been recognized for decades in the mining industry, the nano-scale particulates accompanying with complicated physiochemical properties and their enormous contribution in quantity have been drawing attentions only in recent a few years because of the advancement of nano-science discipline. In this review, we examine the current regulations of dusts exposure and the dominant mass-based monitoring methods to point out the ignorance of nano-particulates in mining industry. The recognized mining-related nano-particulates sources are summarized to identify the mechanically generated finer particulates including particles and aerosols. In addition, the mechanism of adverse health impact on miner with exposure to nano-scale particulates is discussed in a detail to emphasize their substantial detriment as a potential respiratory hazard. Characterization of the complex physiochemical properties of nano-particulates are then summarized and discussed because these properties could be different from regular respirable dusts due to their dramatically increased surface area and particulate counts. The intent of this review is to demonstrate the potential of adverse health effect of nano-particulate on the mine personals throughout the mining cycle and to identify the research gaps of the mine nano-particulate characterization and quantification. We suggest that further understanding of the mining induced nano-particulate properties and their pathogenesis are critical for the future engineering control measure to mitigate the potential health threat for future miners.

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Coal Dust Contiguity-induced Changes in the Concentration of TNF-α and NF-κ B p65 on the Ocular Surface

Cited by 9 publications

References 14 publications

Practical issues concerning tear protein assays in dry eye

Practical issues concerning tear protein assays in dry eye

Analisis Berbagai Macam Biomarker Air Mata dalam Diagnosis Penyakit Mata Kering

Respirable nano-particulate generations and their pathogenesis in mining workplaces: a review

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