Coagulopathy and Bleeding Management for Aortic Dissection Surgery

Levy, Jerrold H.; Sniecinski, Roman M.

doi:10.1007/978-3-030-66668-2_39

Cited by 25 publications

(54 citation statements)

References 82 publications

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“…население на година (в сравнение с миокардния инфаркт, който засяга около 4400 случая на 1 млн. души годишно) [9]. Възрастта е рисков фактор, като около 75% от аортните дисекации се наблюдават при пациенти между 40 и 70 г., като мнозинството е в диапазона 50-65 г.…”

Section: въведение аортна дисекацияunclassified

“…Възрастта е рисков фактор, като около 75% от аортните дисекации се наблюдават при пациенти между 40 и 70 г., като мнозинството е в диапазона 50-65 г. [9]. Обзор от международния регистър на острите аортни дисекации (IRAD) при 464 пациенти докладва, че две трети са били мъже със средна възраст на всички пациент 63 г.…”

Section: въведение аортна дисекацияunclassified

“…Some publications reported an aortic dissection rate of 2.6 to 3.5 per 100,000 people/year [6][7][8]. Elsewhere, it is mentioned that the incidence of aortic dissection is from 5 to 30 cases per 1 million inhabitants per year (compared to myocardial infarction, which affects about 4400 cases per 1 million people per year) [9]. Age is a risk factor, with about 75 % of aortic dissections observed in patients between 40 and 70 years old, the majority in the range of 50-65 years [9].…”

Section: Introduction Aortic Dissectionmentioning

confidence: 99%

“…Elsewhere, it is mentioned that the incidence of aortic dissection is from 5 to 30 cases per 1 million inhabitants per year (compared to myocardial infarction, which affects about 4400 cases per 1 million people per year) [9]. Age is a risk factor, with about 75 % of aortic dissections observed in patients between 40 and 70 years old, the majority in the range of 50-65 years [9]. Review of 464 patients from the International Register of Acute Aortic Dissections (IRAD), two-thirds were men with an average age of all patients 63 years [10].…”

Section: Introduction Aortic Dissectionmentioning

confidence: 99%

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Endovascular treatment of type „A“ and type „B“ dissection of the aorta

Stankov¹,

Petrov²,

Boychev³

2022

Bulgarian Cardiology

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During the period from March 2014 to May 2018, endovascular treatment of aortic dissection type A and type B was carried out in a total of 70 patients. Patients were divided into two groups, aortic dissection type A (14 patients) and type B (56 patients), a group-by-group descriptive analysis was conducted, and then a comparison was done between the two patient groups.  The aim of the study was to establish the effective use of endovascular treatment in type A and type B aorta dissection. As a result of the survey, data on the demographic characteristics and risk profile of these patients are accumulated for the first time in Bulgaria. Endovascular treatment options for the treatment of aortic dissection type A and type B, as well as malperfusion syndrome, are examined, demonstrating their effectiveness and safety. As a result of the study, it is proven that endovascular treatment in aortic dissection type A and type B leads to a significant increase in the size of the true lumen and reduction of the false lumen, which leads to an improvement in perfusion and reduces the risk of developing an aneurysm and rupture.  The presence of endoleak and persistent communication between the false and the real lumen are the most common causes of re-intervention, such as endovascular options are most often the first line for their dealing and are proven to be effective and safe.  Treatment of dissection of the aorta type A and B is not a one-time act, but requires periodic diagnostic control and, if necessary, surfery and/or endovascular corrections of the complications that have arisen.

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Section: въведение аортна дисекацияunclassified

Section: Introduction Aortic Dissectionmentioning

confidence: 99%

Section: Introduction Aortic Dissectionmentioning

confidence: 99%

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Endovascular treatment of type „A“ and type „B“ dissection of the aorta

Stankov¹,

Petrov²,

Boychev³

2022

Bulgarian Cardiology

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“…Aortic dissection (AD) represents a pathological change that separates the true and false lumens of the aorta. Due to rupture of the aortic intima or disease in the media elastic fibrous layer caused by various etiologies, blood in the aortic lumen enters the media through the torn intima, as a result, the media will tear and thus a dual-lumen aorta is formed ( 1 ). AD that develops within 2 weeks is defined as AAD, while AD that develops over 2 weeks later is defined as subacute AD or chronic AD ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Key m6A Modification Related Genes and Immune Infiltrates in Human Aortic Dissection

Yin

Zhang

Guo

et al. 2022

Front. Cardiovasc. Med.

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ObjectiveTo identify the feature of N6-methyladenosine (m6A) methylation modification genes in acute aortic dissection (AAD) and explore their relationships with immune infiltration.MethodsThe GSE52093 dataset including gene expression data from patients with AAD and healthy controls was downloaded from Gene Expression Omnibus (GEO) database in order to obtain the differentially expressed genes (DEGs). The differentially methylated m6A genes were obtained from the GSE147027 dataset. The differentially expressed m6A-related genes were obtained based on the intersection results. Meanwhile, the protein-protein interaction (PPI) network of differentially expressed m6A-related genes was constructed, and hub genes with close relationships in the network were selected. Later, hub genes were verified by using the GSE153434 dataset. Thereafter, the relationships between these genes and immune cells infiltration were analyzed.ResultsA total of 279 differentially expressed m6A-related genes were identified in the GSE52093 and GSE147027 datasets. Among them, 94 genes were up-regulated in aortic dissection (AD), while the remaining 185 were down-regulated. As indicated by Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, these genes were mainly associated with extracellular matrix (ECM) and smooth muscle cells (SMCs). The seven hub genes, namely, DDX17, CTGF, FLNA, SPP1, MYH11, ITGA5 and CACNA1C, were all confirmed as the potential biomarkers for AD. According to immune infiltration analysis, it was found that hub genes were related to some immune cells. For instance, DDX17, FLNA and MYH11 were correlated with Macrophages M2.ConclusionOur study identifies hub genes of AD that may serve as the potential biomarkers, illustrates of the molecular mechanism of AD, and provides support for subsequent research and treatment development.

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