Coagulopathy After Successful Cardiopulmonary Resuscitation Following Cardiac Arrest

Adrie, Christophe; Monchi, Mehran; Laurent, Isabelle; Um, Suzane L.; Yan, S. Betty; Thuong, Marie; Cariou, Alain; Charpentier, Julien; Dhainaut, Jean François

doi:10.1016/j.jacc.2005.03.046

Cited by 185 publications

(145 citation statements)

References 33 publications

(40 reference statements)

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“…11 The mechanisms of unfavorable outcomes after resuscitation from OHCA in 6 patients with PCAS include both myocardial dysfunction and whole-body ischemia and reperfusion syndrome responsible for a systematic inflammatory response similar to that in severe sepsis. [11][12][13][14] Whole-body ischemia and reperfusion-induced endothelial injury contributes to thrombotic occlusion of the vessels following activation of coagulation and impairment of fibrinolysis. 13,[15][16][17][18] These changes lead to disseminated intravascular coagulation (DIC) in patients resuscitated from cardiac arrest.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13][14] Whole-body ischemia and reperfusion-induced endothelial injury contributes to thrombotic occlusion of the vessels following activation of coagulation and impairment of fibrinolysis. 13,[15][16][17][18] These changes lead to disseminated intravascular coagulation (DIC) in patients resuscitated from cardiac arrest. 16,17 DIC causes thrombotic occlusion of vessels, followed by deteriorated oxygen supply to cells and tissues.…”

Section: Introductionmentioning

confidence: 99%

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Fibrin/fibrinogen degradation products (FDP) at hospital admission predict neurological outcomes in out-of-hospital cardiac arrest patients

et al. 2017

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Objective: This study aimed to test the hypothesis that coagulation, fibrinolytic markers and disseminated intravascular coagulation (DIC) score (International Society on Thrombosis and Haemostasis) at hospital admission of out-of-hospital cardiac arrest (OHCA) patients can predict neurological outcomes 1 month after cardiac arrest. Results: We analyzed data for 315 patients. Except for fibrinogen level, all coagulation variables, fibrinolytic variables, and DIC score were associated with favorable neurological outcomes. In the receiver operating characteristic curve analysis, FDP level had the largest area under the curve (AUC; 0.795). In addition, the AUC of FDP level was larger than that of 4 lactate level. The AUC value of FDP level might indicate that FDP is an independent predictor of favorable neurological outcomes. Conclusions:All of the coagulation and fibrinolytic markers, except for fibrinogen level, and DIC score at hospital admission, were associated with favorable neurological outcomes. Of all of the variables, FDP level was most closely associated with favorable neurological outcomes in OHCA patients who successfully achieved ROSC. 5

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fibrin/fibrinogen degradation products (FDP) at hospital admission predict neurological outcomes in out-of-hospital cardiac arrest patients

et al. 2017

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“…Indeed, after cardiac resuscitation there is a greater pro-thrombotic activity and overall decrease of anticoagulant factors (antithrombine II, protein C and S). These alterations are pronounced in patients who die in the fi rst two days 31 . Anticoagulation may contribute to decrease the risk of another CA, more so after myocardial infraction or pulmonary embolism 20 .…”

Section: Anticoagulationmentioning

confidence: 99%

Abordagem do paciente reanimado, pós-parada cardiorrespiratória

Pereira¹

2008

Rev. bras. ter. intensiva

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SUMMARY BACKGROUND AND OBJECTIVES:Out-of-hospital cardiac arrest is a major cause of death with survival rates as low as 5% to 35%. A large number of patients who survive resuscitation will face significant neurological damage, as a result of the ischemia that occurs both during cardiac arrest and reperfusion. However understanding of the mechanisms responsible for brain damage has not resulted in prognostic improvement. Therapeutic hypothermia after resuscitation may be a valid option associated to reduction of neurological damage. The purpose of this study was to review scientific evidence related to a therapy for patients resuscitated from cardiac arrest. CONTENTS: Description and analysis of the main risk factors associated with neurological damage after resuscitation from cardiac arrest as well as prognostic criteria was carried out. A non-systematic search was conducted in the PubMed data base for papers on a therapeutic approach for patients resuscitated from cardiac arrest. Bibliographic references of reviewed papers were also analyzed. Practical rules were drafted for such an approach.

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“…Rushing and transport the patient to cath lab or radiology without prior stabilisation is cumbersome and harmful. Moreover, when a coronary cause of cardiac arrest is identified, the risk of bleeding associated to unavoidable antiplatelet and anticoagulant therapy might be too high (32,33).…”

Section: Federico Pappalardo 1 Andrea Montiscimentioning

confidence: 99%

What is extracorporeal cardiopulmonary resuscitation?

Pappalardo¹,

Montisci²

2017

J. Thorac. Dis.

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Coagulopathy After Successful Cardiopulmonary Resuscitation Following Cardiac Arrest

Abstract: Major coagulation abnormalities were found after successful resuscitation of cardiac arrest. These abnormalities are consistent with secondary down-regulation of the thrombomodulin-endothelial protein C receptor pathway.

Cited by 185 publications

References 33 publications

Fibrin/fibrinogen degradation products (FDP) at hospital admission predict neurological outcomes in out-of-hospital cardiac arrest patients

Fibrin/fibrinogen degradation products (FDP) at hospital admission predict neurological outcomes in out-of-hospital cardiac arrest patients

Abordagem do paciente reanimado, pós-parada cardiorrespiratória

What is extracorporeal cardiopulmonary resuscitation?

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