Coagulation Studies in 45 Cases of Nephrotic Syndrome without Uremia

Abstract

SummaryCoagulation studies were performed in 45 cases of nephrotic syndrome without uremia. The most striking features were an increase in the number of thrombocytes, and in the level of fibrinogen, factor V and factor VIII. Thrombin time was usually prolonged and the titre of antithrombin III was increased. No fibrin breakdown products were found in the serum. 13 patients developed thrombotic complications, with eventual death in 5 cases.

Plasma soluble fibrin monomer complexes in nephrotic syndrome-with reference to hypoalbuminemia.

“…Fbg is one of these factors, and the increase of this factor was thought to be induced as a nonspecific hepatic response to heavy proteinuria (Takeda 1967). In agreement with the previous reports (Kanfer et al 1970), the majority of our patients showed increased levels of Fbg and proteinuria with hypoalbuminemia.…”

“…It has been stated that nephrotic syndrome is often associated with hypercoagulability (Kanfer et al 1970 ;Kendall et al 1971;Thomson et al 1974). The cause is, however, still uncertain.…”

Nephrotic Syndrome and Anticoagulant Therapy.

“…There is a @@Table1. Systemic Thrombolism in Nephrotic Syndrome @@NephroticSyndrome and Anticoagulant Therapy correlation between increases in Factor V and Factor VIII, and a fall in serum albumin (7). An increase in these coagulation factors might contribute to the high incidence of thromboembolism in nephrotic syndrome.…”

Blood Coagulation and the Nephrotic Syndrome: Deficiency or Excess?

“…[1][2][3] Although the association between nephrotic syndrome and thromboembolic complications has been recognized for more than a century, the precise causal relationship is not entirely understood. [4][5][6] Moreover, the association between the increased bleeding tendency and nephrotic syndrome is also somewhat unclear. [2][3][4][5][6][7] In this review, we present a current synopsis on the subject and discuss some of the controversial aspects that have emerged during the past decade.…”

“…[4][5][6] Moreover, the association between the increased bleeding tendency and nephrotic syndrome is also somewhat unclear. [2][3][4][5][6][7] In this review, we present a current synopsis on the subject and discuss some of the controversial aspects that have emerged during the past decade. 8,9 An in-depth understanding of the underlying pathogenesis should pave the way to better clinical methods for preventing these grave complications.…”