Coagulation responses after a submaximal exercise in sickle cell trait carriers

Beltan, Eric; Chalabi, Tawfik; Tripette, Julien; Chout, R.; Connes, Philippe

doi:10.1016/j.thromres.2010.09.012

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…Our findings demonstrated no differences in APTT, PT and FII coagulation in diabetics and they were consistent with the results obtained by Lamprechts et al 24 that showed no statistically significant differences between pre-and post a single bout of walking exercise in APTT, FII coagulation and PT in the obese women. A short-term exercise in healthy subjects is usually associated with a significant shortening of APTT 25,26 , but according to our results there was no differences in APTT after regular eight-week training. According to Lockard et al 18 plasma prothrombin fragment was found to decrease significantly with exercise training three times a week in six months.…”

Section: Discussionsupporting

confidence: 47%

Correlation between coagulation and inflammation state in patients with diabetes mellitus type 2 in relation to gender differences: Is there any impact of eight-week exercise training?

Trebinjac

Petronić²,

Lalić

et al. 2019

VOJNOSANIT PREGL

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Background/Aim. The hypercoagulable state and inflammation state in diabetics has been widely studied by previous researchers, but there is a lack of research about a possible impact of exercise training on this relationship. The aim of this study was to assess and compare correlation between the coagulation and inflammation status in patients with type 2 diabetes mellitus taking into account the gender differences as well as an impact of the 8-week exercise training on the correlation coefficient and parameters of the inflammation and coagulation state. Methods. A total of 60 patients in stable clinical condition and well-regulated diabetic status passed through all phases of the study. The exercise training included the exercise program as interval training with estimated intensity uphill to 75% of a maximal heart rate in particular individual, 5 times a week for 8 weeks, and walking for 30 minutes with a speed of 5 km/h, 5 times a week for 8 weeks. Further fibrinolytic, coagulation and inflammatory parameters were analyzed before and after the study: D-dimer, von Willebrand factor (vWF), fibrinogen, high sensitivity CRP (hs-CRP), leukocytes, thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT) and coagulation factors: FII, FV, FVII and FX. Results. Our research showed a statistically significant reduction in the mean vWF levels after intervention both at the males (p < 0.001) and females (p < 0.001). According to a correlation analysis between hs-CRP and fibrinogen, there was a positive correlation as baseline both at the males (p < 0.05, r = 0.492) and females (p < 0.01, r = 0.516) which became weaker in the males (p < 0.01, r = 0.449) and disappeared in the females (p < 0.05, r = 0.059) after intervention. The correlation which existed as baseline in the males between D-dimer and either hs-CRP (p < 0.01, r = 0.633) or fibrinogen (p < 0.01, r = 0.673) as well as the correlation between hs-CRP and FII (p < 0.01, r = 0.728), FV (p < 0.05, r = 0.366), FVII (p < 0.05, r = 0.373) coagulation as well as between D-dimer and FII (p < 0.01, r = 0.851), FVII (p < 0.05, r = 0.367)was absent in the females. Our research demonstrated a weakening correlations in the males after intervention between D-dimer and hs-CRP (p < 0.05, r = 0.378), between hs-CRP and FII (p < 0.01, r = 0.501), FV (p < 0.05, r = 0.298), FVII (p < 0.05, r = 0.351) as well as between D-dimer and FII (p < 0.01, r = 0.759), and FVII (p < 0.05, r = 0.296). The increase of the FX values (p < 0.05) in the females after intervention suggested the possible antiinflammatory effect of exercise training. Conclusion. According to previous research, the higher levels of vWF was associated with a risk of cardiovascular disease in people with type 2 diabetes mellitus and vWF may be a risk factor unique to these populations. We demonstrated that the 8-week exercise training can significantly reduce the value of vWF in the males and females, suggesting a potential beneficial effect on the endothelial function parameters. Our research demonstrated a stronger correlation between the coagulation and inflammation parameters as baseline in the males than in the females with type 2 diabetes mellitus. According to our results, the 8-week exercise training lead to a weakening of the strength of correlation between the coagulation and inflammation parameters in the males and complete disappearance of this correlation in the females, suggesting a unique effect of exercise training that should be explored in future research.

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Section: Discussionsupporting

confidence: 47%

Correlation between coagulation and inflammation state in patients with diabetes mellitus type 2 in relation to gender differences: Is there any impact of eight-week exercise training?

Trebinjac

Petronić²,

Lalić

et al. 2019

VOJNOSANIT PREGL

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“…As such, several investigations have monitored these biological factors in response to exercise. To date, the main findings include the following: 1) SCT carriers at rest have increased blood viscosity (19,86,90), slightly decreased RBC deformability (19,87), somewhat inereased RBC disaggregation threshold (87), and increased plasma eoncentration of the adhesion molecule vascular cell adhesion molecule 1 (4,67,68); 2) exercise results in a greater decrease in RBC deformability in SCT carriers than that in controls during late exercise recovery (89), but adequate hydration normalizes the hemorheological abnormalities of SCT carriers (90); 3) exercise results in a greater activation of leucocytes and platelets in SCT carriers than that in non-SCT controls (88); and 4) SCT carriers and controls exhibit very few differenees in eoagulation processes (7,24,100).…”

Section: Is Sct An Independent Risk Factor For Ecast?mentioning

confidence: 99%

ACSM and CHAMP Summit on Sickle Cell Trait

O’Connor

Bergeron²,

Cantrell

et al. 2012

Medicine &Amp; Science in Sports &Amp; Exercise

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“…All this considered, there were few differences in the coagulation process found in these studies between SCT carriers and controls. 50,51,52,53 Other studies indicated that although there is a greater blood viscosity in SCT carriers, serum creatine kinase and lactate dehydrogenase levels were very similar between SCT carriers and controls during exercise. 52,54 Although there were no differences to note, it was considered that the type and intensity of exercise were not great enough to determine whether or not SCT carriers possess a higher risk of exertional rhabdomyolysis or exertional sickling during exercise than non-SCT carriers.…”

Section: Significance Of the Studymentioning

confidence: 98%

Knowledge and Awareness of Sickle Cell Trait among NCAA Division I FBS, Division I FCS, Division II, and Division III Head Football Coaches and Strength and Conditioning Specialists

Yates¹

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specialists, 71 began the survey and 59 completed the knowledge section for a return rate of 6.2%, while only 49 (5.1%) completed the demographic section. There were twenty (40.8%) head football coaches and twenty-nine strength and conditioning specialists (59.2%). The majority of participants (40.8%, n=21) were from NCAA Division III and the least (14.3%, n=7) were from NCAA Division I FBS. Sixty-eight of the 71 participants who began the survey reported they had heard of SCT previously. The top three sources selected for where participants obtained knowledge of SCT were 1) certified athletic trainer (67.8%, n=40); 2) experience with an athlete (47.5%, n=28); and 3) college course (39.0%, n=23). The top three signs and symptoms selected that may be associated with SCT were 1) muscle weakness (72.9%, n=43); 2) sensation of cramping muscles (64.4%, n=38); and 3) sudden collapse (50.8%, n=30), which were all correct responses.

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Coagulation responses after a submaximal exercise in sickle cell trait carriers

Cited by 5 publications

References 18 publications

Correlation between coagulation and inflammation state in patients with diabetes mellitus type 2 in relation to gender differences: Is there any impact of eight-week exercise training?

Correlation between coagulation and inflammation state in patients with diabetes mellitus type 2 in relation to gender differences: Is there any impact of eight-week exercise training?

ACSM and CHAMP Summit on Sickle Cell Trait

Knowledge and Awareness of Sickle Cell Trait among NCAA Division I FBS, Division I FCS, Division II, and Division III Head Football Coaches and Strength and Conditioning Specialists

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