Coagulation profile in patients with H1N1 influenza A infection undergoing treatment for haematological malignancies

Abstract

Patients with haematological malignancies receiving concurrent treatment or after allogeneic stem cell transplantation (HSCT) are considered to be at increased risk for acquiring influenza A (H1N1) infection (pH1N1) and influenza-associated complications leading to increased mortality. We report of a series of haematological patients with severe course of laboratory-confirmed pH1N1, including two patients after HSCT. Coagulation assays were conducted and the association between coagulation activation and poor outcome pH1N1 infection was found in the analyzed group.

Assessment of coagulation profile by thromboelastometry in adult patients with cyanotic congenital heart disease

“…To find the influence of platelets, haematocrit and fibrinogen on the ROTEM parameters, a full blood count with platelet count (×10 9 /l) and plasma fibrinogen were determined by routine laboratory techniques, as previously described [21,22]. Plasma fibrinogen (the Clauss method) was performed as recommended by the manufacturer (Instrumentation Laboratory Company -Bedford USA), whereas the whole blood fibrinogen concentration (WBFC, g/L) was calculated as the plasma fibrinogen concentration × (1 -haematocrit) [23].…”