Coagulation parameters are associated with the prognosis of immunoglobulin A nephropathy: a retrospective study

Abstract

Background. Interstitial fibrosis/tubular atrophy (T) score is a known determinant of the progression of immunoglobulin A nephropathy (IgAN). Strong evidence indicates that the components of the coagulation system closely linked with fibrotic events have been highlighted in the kidney. However, whether the coagulation system can affect the renal outcome of IgAN remains unclear. Herein, we investigated the association of coagulation parameters and pathological phenotype of IgAN and their combined effects on the deterioration of renal function.Methods. This retrospective study included N=291 patients with biopsy-proven IgAN from May 2009 to April 2013 in the Second Xiangya Hospital. Clinical data, pathological features were collected, and the associations of coagulation parameters at biopsy, T score, and renal outcome were evaluated. T score indicated the degree of tubular atrophy or interstitial fibrosis. The renal outcome was defined as an end-stage renal disease (ESRD) or an irreversible 50% estimated glomerular filtration rate (eGFR) reduction. Results. Shorter prothrombin time (PT) and the activated partial thromboplastin time (APTT) were significantly associated with T (both p<0.001). PT (<11.15s) or APTT (<29.65s) had worse cumulative survival rate (p=0.008, p=0.027 respectively) and were significantly but not independently associated with a higher risk of renal outcome (p=0.012, p=0.032 respectively). In the combined analyses of PT, APTT, and T lesions, the odd ratios for the outcome were significantly higher in the presence of T with PT (<11.15s) or APTT (<29.65s).Conclusion. Shorter PT and APTT are associated with an increased incidence of the T lesion and are additional factors that portend a poorer prognosis in IgAN. Monitoring coagulation function might be important when assessing the risk of progression. Additional studies exploring the molecular mechanism between coagulation and IgAN pathology are needed.

Coagulation potential in pediatric patients with immunoglobulin A nephropathy

“…Thus, endothelial cell injury, coagulation factors, and platelet activity are associated with intraglomerular coagulation and the development of glomerulonephritis. However, few studies have evaluated clinical coagulation in patients with glomerulonephritis 27 …”

“…However, few studies have evaluated clinical coagulation in patients with glomerulonephritis. 27 Rotational thromboelastometry, a whole-blood viscoelastic monitoring method, is capable of evaluating coagulation potential comprehensively, including coagulation factors, platelets, and blood cell components. In the present study, most plasma-based conventional laboratory data related to coagulation showed no significant difference, whereas the ROTEM parameters were significantly different between pediatric patients with IgAN and controls.…”

Effects of Tang Shen 2 Hao Fang, a Traditional Chinese Medicine, on Diabetic Nephropathy in Sprague–Dawley Rats

“…35,36 Cicada slough reduces IgA nephropathy, 37 an immune-mediated inflammatory condition of the glomerulus. 38 With its antiinflammatory and antioxidant effects and the capability to lower blood glucose and blood lipids by different mechanisms, the combination of components in this natural traditional Chinese remedy partially remedied disease-causing diabetic kidney injury in rats.…”