Coagulation parameters abnormalities and their relation to clinical outcomes in hospitalized and severe COVID-19 patients: prospective study

Esmaeel, Hend M.; Ahmed, Heba A.; El-Badry, Mahmoud; Khalaf, Asmaa R.; Mohammed, Nesreen; Mahmoud, Hamza A.; Taha, Elhaisam M.

doi:10.1038/s41598-022-16915-8

Cited by 8 publications

(15 citation statements)

References 32 publications

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“…According to the results, it was noted that deaths were observed only in the severe group. In the study conducted by Esmaeel et al, 33 ROC analysis and predictive values were noted for the prediction of the group in which the disease was severe and deaths occurred, and it was observed that AUC = 0.940, sensitivity 76.0%, and specificity 93.0% at d-dimer 2.0 ng/L cut-off value ( P < .001). Our study was conducted with a larger sample size of 498 patients and included patients with both PCR positivity and COVID-related thorax CT involvement.…”

Section: Discussionmentioning

confidence: 98%

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Investigation of the relationship between coagulation parameters and mortality in COVID-19 infection

Ikiz,

2024

Blood Science

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This study, which included patients over the age of 18 who were diagnosed with coronavirus disease 2019 (COVID-19) in the emergency clinic, aims to determine the relationship between coagulation parameters and mortality. Epidemiologic data such as age, gender, medical history, vital parameters at emergency department admission, clinical findings, coagulation parameters such as d-dimer, prothrombin time (PT), active partial thromboplastin time (aPTT), international normalized ration (INR), fibrinogen, and platelet were evaluated. Patients with positive computerized tomography (CT) findings and positive polymerase chain reaction (PCR) together were included in the study. It was revealed that d-dimer, fibrinogen, INR, and PT values were higher in the elderly group. It was shown that there was a significant relationship between hospitalization days (ward or intensive care unit) and d-dimer levels. It was observed that d-dimer, fibrinogen elevation was significantly associated with prognosis by increasing mortality, and that platelet and aPTT values were also associated with prognosis and were lower in the mortality group. On the other hand, in receiver operating characteristic (ROC) analysis, the sensitivity and specificity data were 80.3%/80.0% for d-dimer, 70.5%/72.2% for fibrinogen, 58.2%/59.4% for aPTT, and 59.7%/59.2% for platelet, respectively. The overall classification success was 88.6% and mortality prediction success was 37.7% in the regression model of some coagulation parameters (d-dimer, fibrinogen, aPTT, and platelet) which were effective on prognosis. In conclusion, it was determined that d-dimer, fibrinogen, aPTT, and platelet parameters were directly associated with mortality and when these coagulation parameters were used together with the clinical, vital, and demographic data of the patients, the success of mortality prediction increased significantly.

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Section: Discussionmentioning

confidence: 98%

“…In 2021, in a study conducted on 267 COVID-19 patients, Esmaeel et al 33 compared biochemistry and coagulation parameters on disease severity and investigated their relationship with mortality. In the study, PCR positivity was taken as the diagnostic criteria for COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the relationship between coagulation parameters and mortality in COVID-19 infection

Ikiz,

2024

Blood Science

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“…Furthermore, the ndings indicated that there is a signi cant and direct correlation between IL-6 and CRP and D-dimer, although a negative and signi cant correlation was observed between HIF-1α and D-dimer, IL-6 and CRP. It has been shown that coagulation disorders are present in patients with COVID-19 (10); under these conditions, the activity of the brinolytic system is increased, and D-dimer is formed from brin (11). Thus, increasing the level of D-dimer is an indicator for coagulation disorders associated with COVID-19 infection (11,12), and it has been shown that the level of D-dimer is signi cantly elevated during COVID-19 (13).…”

Section: Discussionmentioning

confidence: 99%

The role of HIF-1α in COVID-19 pathogenesis and its correlation with IL-6 and other inflammation parameters

Khalid

Asadi

Palani

et al. 2023

Preprint

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Inflammation has a crucial role in COVID-19 pathogenesis, and previous studies have proposed an important function of IL-6 during inflammation. On the other hand, IL-6 levels and inflammation might be associated with hypoxia-inducible factor-1α (HIF-1α). Thus, due to the possible role of HIF-1α in inflammation and COVID-19 pathogenesis, we aimed to investigate the levels of HIF-1α and its correlation with inflammatory parameters (IL-6 and CRP) and D-dimer. In this case-control study, 84 patients (54 patients hospitalized in the ICU and 30 individuals as outpatient subjects) were included as the case group, and 50 healthy subjects were included as the control group. The levels of D-dimer, CRP, IL-6 (interleukin 6) and HIF-1α were assessed in all studied groups. The results of the present investigation showed that the levels of D-dimer, CRP and IL-6 were significantly increased in COVID-19 patients compared to healthy individuals. On the other hand, the level of HIF-1α significantly decreased in COVID-19 patients. In addition, there was a significant correlation between IL-6 and CRP and D-dimer, while HIF-1α was indirectly correlated with IL-6, CRP and D-dimer. Ultimately, our data indicated that the levels of CRP, D-dimer, IL-6 and HIF-1α were significantly different between ICU patients and the outpatient group with healthy individuals. Based on the study results, inflammation plays a crucial role in COVID-19 pathogenesis, and low HIF-1α is a consequence of inflammation due to COVID-19 infection and might have a protective role in COVID-19.

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“…Koagülasyon parametrelerinin değerlendirildiği bir derlemede aPTT ve PLT değerleri mortalite için öngörücü bulunmuş, fibrinojen yüksekliğinin YB'a yatış ile ilişkisi belirlenmiştir (24). Literatürde araştırma sonucumuza benzer şekilde, aPTT, fibrinojenin prognozda öngörücü olmadığını değerlendiren çalışmalar da bulunmaktadır (1,19,25). (1,20).…”

Section: Gereç Ve Yöntemlerunclassified

Yoğun Bakımdaki COVID-19 Hastalarında Prognostik Belirteçler: Hemostatik Parametreler Mortaliteyi Öngörebilir mi?

Kayar Çalılı,

Özercan,

Demirçakan

et al. 2023

JARSS

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Objective: Our study aimed to investigate whether primarily hemostasis parameters and secondarily demographic, clinical, and laboratory values could predict the mortality of critically ill Coronavirus Disease 2019 (COVID-19) patients. Methods: We retrospectively examined 180 laboratory-confirmed adult intensive care unit (ICU) patients with COVID-19. A total of 145 patients with complete records were included in the study. The patients were divided into two groups: deceased (n=58) and discharged (n=87). The demographic and clinical characteristics of the two groups, use of vasopressor therapy, requirement for invasive mechanical ventilation (IMV), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, duration of ICU stay, and the relationship between laboratory values on ICU admission and mortality were evaluated using cutoff values. Results: Among hemostatic parameters, only D-dimer>1.08 mg L-1 was found to be a significant predictor of mortality (p=0.04), while platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), International Normalized Ratio (INR) and fibrinogen values were not significantly associated with mortality (p>0.05). In addition, age >76 years, hypertension (HT), need for IMV, APACHE II score >23, procalcitonin (PCT) >0.21 μg L-1, lymphocytes <0.4 109 L-1, interleukin 6 (IL-6) >93 pg mL-1 were found to be predictors of mortality (p<0.05). Neutrophil and C-reactive protein (CRP) values were not significantly associated with mortality (p>0.05). ABSTRACT Conclusion: Our study determined that advanced age, HT, high APACHE II score, requirement for IMV, vasopressor therapy, PCT, lymphocyte count, IL-6, and D-dimer levels could serve as predictors of mortality. Identifying predictors of mortality in COVID-19 is valuable for early recognition of disease progression and management of potential complications. Keywords: COVID-19, mortality, hemostasis, clinical markers, laboratory markers

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Coagulation parameters abnormalities and their relation to clinical outcomes in hospitalized and severe COVID-19 patients: prospective study

Cited by 8 publications

References 32 publications

Investigation of the relationship between coagulation parameters and mortality in COVID-19 infection

Investigation of the relationship between coagulation parameters and mortality in COVID-19 infection

The role of HIF-1α in COVID-19 pathogenesis and its correlation with IL-6 and other inflammation parameters

Yoğun Bakımdaki COVID-19 Hastalarında Prognostik Belirteçler: Hemostatik Parametreler Mortaliteyi Öngörebilir mi?

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