Coagulation Factor Xiii a and B Subunits in Bone Marrow and Liver Transplantation

Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency

“…24 The main site of production of the circulating FXIII-A 2 subunits is still debated because there is evidence for synthesis in the liver and the bone marrow. 25,26 The liver is thought to be the site of synthesis of the FXIII-B subunit. 27 At the 3 highest rFXIII-A 2 doses administered, after the initial decrease in FXIII-B subunit levels, a steady increase in newly formed rFXIII-A 2 B 2 was observed in the first 24 hours.…”

Roles of transglutaminases in cardiac and vascular diseases

“…Factor XIII is expressed primarily by bone-marrow derived cells including platelets, monocytes and macrophages (53). In contrast, TG2 is widely expressed by cardiac and vascular cells including endothelial and smooth muscle cells which constitutively express TG2 at high levels (54).…”

“…The factor XIII A subunit can be synthesized in the liver (65) and in the bone marrow (53). The liver cells that synthesize Factor XIII A chains include hepatocytes, Kupffer cells and connective tissue histocytes (66).…”

Factor XIII-A transglutaminase acts as a switch between preadipocyte proliferation and differentiation

“…12 In contrast to most of the other clotting factors, the source of circulating FXIII-A is considered to be predominantly cells of bone marrow origin such as megakaryocytes. 13,14 In addition to being found in plasma, FXIII-A is also found in tissues and is synthesized by various cells, including macrophages, chondrocytes, osteoblasts, and osteocytes, where it is found in the cytosol and nucleus, on the plasma membrane or cell surface, and in the extracellular matrix.…”