Coagulation Factor XIIa-kinin-mediated contribution to hypertension of chronic kidney disease

Papageorgiou, Peter C.; Chan, Christopher T.; Yeo, Erik; Backx, Peter H.; Floras, John S.

doi:10.1097/hjh.0000000000000192

Cited by 11 publications

(6 citation statements)

References 46 publications

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“…Among these genes, CRIP1 , MYADM , TIPARP , F12 , and TSC22D3 have been previously implicated in hypertension. 15,19,33–35 For the other transcripts, a connection to diseases related to BP, such as obesity and CVD, as well as important roles in the immune system have been described, 36 but the association with BP traits is novel. These findings seem plausible because numerous studies suggest that hypertension represents an inflammatory state and an involvement of the immune system and, in particular, monocytes in the development of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure

et al. 2017

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Hypertension represents a major cardiovascular risk factor. The pathophysiology of increased blood pressure (BP) is not yet completely understood. Transcriptome profiling offers possibilities to uncover genetics effects on BP. Based on 2 populations including 2549 individuals, a meta-analyses of monocytic transcriptome-wide profiles were performed to identify transcripts associated with BP. Replication was performed in 2 independent studies of whole-blood transcriptome data including 1990 individuals. For identified candidate genes, a direct link between long-term changes in BP and gene expression over time and by treatment with BP-lowering therapy was assessed. The predictive value of protein levels encoded by candidate genes for subsequent cardiovascular disease was investigated. Eight transcripts (CRIP1, MYADM, TIPARP, TSC22D3, CEBPA, F12, LMNA, and TPPP3) were identified jointly accounting for up to 13% (95% confidence interval, 8.7–16.2) of BP variability. Changes in CRIP1, MYADM, TIPARP, LMNA, TSC22D3, CEBPA, and TPPP3 expression associated with BP changes—among these, CRIP1 gene expression was additionally correlated to measures of cardiac hypertrophy. Assessment of circulating CRIP1 (cystein-rich protein 1) levels as biomarkers showed a strong association with increased risk for incident stroke (hazard ratio, 1.06; 95% confidence interval, 1.03–1.09; P=5.0×10−5). Our comprehensive analysis of global gene expression highlights 8 novel transcripts significantly associated with BP, providing a link between gene expression and BP. Translational approaches further established evidence for the potential use of CRIP1 as emerging disease-related biomarker.

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Section: Discussionmentioning

confidence: 99%

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure

et al. 2017

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“… No Francois et al 74 2020 In vivo Does routine hemodialysis increase FXII, FXI, or PK activation compared to baseline levels or compared to control participants? No Papageorgiou et al 75 2014 In vivo Is FXIIa higher in patients with ESKD receiving long-term hemodialysis compared with healthy controls? Yes Hong et al 76 2001 Ex vivo Does FXIIa play a role in thrombin generation when whole blood is incubated with PVC?…”

Section: Contact Activation In Hemodialysismentioning

confidence: 99%

“… 74 On the other hand, an additional study showed that FXIIa was 3 times higher in patients with ESKD receiving long-term hemodialysis compared with healthy controls. 75 The contradictory findings of these studies could be attributed to the differing populations, the small sample sizes, or the difficulties associated with measuring contact activation in vivo, including the sensitivity of different laboratory markers as well as the potential for artifactual (ex vivo) activation of FXII after blood has been drawn.…”

Section: Contact Activation In Hemodialysismentioning

confidence: 99%

“…Animal studies have suggested that transient increases in bradykinin cause acute hypotension, whereas continuous bradykinin infusion results in increased mean arterial pressure. 99 Recent work by Papageorgiou et al 75 showed that during hemodialysis the activation of FXII positively correlated with mean arterial pressure and peripheral resistance in humans. Furthermore, in a mouse model of ESKD, FXIIa-kininogen-mediated vasoconstriction contributed significantly to hypertension.…”

Section: Possible Contributions Of Contact System Activation To Cvd Riskmentioning

confidence: 99%

See 1 more Smart Citation

Hemodialysis-Related Complement and Contact Pathway Activation and Cardiovascular Risk: A Narrative Review

Skinner¹,

Derebail

Poulton

et al. 2021

Kidney Medicine

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“…Kallikrein is derived from the blood plasma or tissue and formed from conversion of prokallikrein by factor XIIa, which is activated in the blood coagulation process. Kallikrein is a serine protease that cleaves kininogen to release vasoactive kinins and activates factor XIIa (positive feedback) (Clermont et al, 2011;Papageorgiou et al, 2014).…”

Section: Kallikreinmentioning

confidence: 99%