Coagulation Factor and Theranostics: A New Paradigm in Molecular Imaging

Urbain, Jean-Luc

doi:10.2967/jnumed.115.165852

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Therefore, an approach encompassing a common target/receptor over-expressed in a wide range of sarcoma sub-types shall serve as pan-sarcoma disease targets for future radio-theranostic applications. The newer radio-theranostic applications in various advanced-stage cancers are fast emerging, and offer promising opportunities but have associated challenges [44,45].…”

Section: Discussionmentioning

confidence: 99%

68Ga-Pentixafor PET/CT for in-vivo mapping of CXCR4 receptors as potential radiotheranostic targets in soft tissue and bone sarcoma: preliminary results

Jena,

Watts,

Aggarwal

et al. 2023

Nuclear Medicine Communications

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Objective To evaluate the diagnostic utility of 68Ga-Pentixafor PET/CT for in vivo imaging of CXCR4 receptors in soft tissue/bone sarcoma. Methods Ten (7M: 3F; mean age = 24.7 ± 14.2 years) consecutive patients with clinical and radiological evidence of bone/soft tissue sarcoma were recruited prospectively whole body 68Ga-Pentixafor PET/CT imaging was performed at 60-min after tracer administration. After performing standard CT, PET acquisition from head to toe was done (3 min/bed position) in a caudocranial direction. PET/CT data was reconstructed and SUVmax, SUVmean values, target-to-background ratio (TBR) and active tumor volume (cc) were computed for the tracer avid lesions. Histopathological and IHC analysis was performed on the surgically excised primary tumors. CXCR4 receptors’ intensity was evaluated by visual scoring. Results The mean SUVmax and SUVmean values in the primary tumors were 4.80 ± 1.0 (3.9–7.7) and 2.40 ± 0.60 (0.9–4.0). The mean TBR and tumor volume (cc) were 1.84 ± 1.3 and 312.2 ± 285. Diagnosis of osteosarcoma in 7, chondrosarcoma, leiomyosarcoma and synovial sarcoma in 1 patient each was confirmed on HP analysis. Distant metastatic lesions were seen in 3/10 patients. Nuclear CXCR4 receptors’ positivity was seen in 5, cytoplasmic in 4 and both pattern seen in 1 patient. The mean CXCR4 receptors’ intensity was found to be 7.6 ± 2. The highest SUVmax value of 7.7 was observed in the patient having both cytoplasmic and nuclear CXCR4 expression. SUVmax was found to be poorly correlated (r = 0.441) with CXCR4 expression. Conclusion 68Ga-Pentixafor PET/CT detects CXCR4 receptors over-expressed in sarcoma, its radio-theranostics potential needs detailed evaluation.

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Section: Discussionmentioning

confidence: 99%

68Ga-Pentixafor PET/CT for in-vivo mapping of CXCR4 receptors as potential radiotheranostic targets in soft tissue and bone sarcoma: preliminary results

Jena,

Watts,

Aggarwal

et al. 2023

Nuclear Medicine Communications

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“…Theranostics is poised to become a standard approach in nuclear medicine as more radiopharmaceutical pairs are discovered and validated. This approach has the potential to dramatically improve patient outcomes by providing highly personalized treatment plans [5][7] [8]. It is an exciting avenue for the field as it aligns with the broader trend towards personalized and precision medicine [9].…”

Section: The Rise Of Theragnosticmentioning

confidence: 99%

Untitled

2024

IJCMCR

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Nuclear medicine, a groundbreaking field that uses small amounts of radioactive material for diagnosing and treating various diseases, has revolutionized healthcare. This article provides a comprehensive exploration of the promising future of nuclear medicine, including the development of novel radionuclides, advancements in imaging technology, the emergence of theranostics, and the challenges the field currently faces. The research delves into the potential of alpha-emitting radionuclides like actinium-225 and thorium-227 for targeted cancer therapy, alongside advancements in radiopharmaceuticals that could usher in an era of precision medicine. The article also examines improvements in imaging technology, such as total-body PET scanners, and the burgeoning field of theranostics, which combines diagnostics and therapy. Despite the numerous advancements, the article highlights the challenges that must be addressed, including regulatory hurdles, high production costs, and radiation safety concerns. The future of nuclear medicine is poised for significant breakthroughs that could redefine the healthcare landscape, and this article provides an in-depth look at these emerging trends and possibilities.

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“…2,3 RPs are, therefore, widely used in diagnostic imaging procedures like single-photon emission computed tomography and positron emission tomography. [4][5][6][7] The precision of these imaging techniques allows healthcare professionals to identify and evaluate various ailments with accuracy. 8 However, while RPs offer remarkable accuracy in diagnosis and treatment, several usage challenges exist.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Use of Ambientally Stored Methylene Diphosphonate Radiopharmaceutical Aliquots in Solving Challenging Situations in Developing Countries

Zulu,

Katebe,

Ramli

et al. 2024

World J Nucl Med

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Objectives The primary aim was to evaluate the prolonged quality characteristics of methyl diphosphonate (MDP) aliquots during ambient storage over a specified duration. This study further investigated potential additives that could enhance the stability of MDP aliquots stored under such conditions. Materials and Methods This was a laboratory-based experimental study conducted at the University Teaching Adult Hospital in Lusaka, Zambia. A total of 36 MDP aliquots stored at ambient conditions and 4 MDP aliquots stored at conventional refrigerated frozen conditions were labeled with technitium-99m (99mTc) and tested for radiochemical purity (RCP) and other quality characteristics. A comparative analysis of the stability and quality of MDP aliquots from the two cohorts was then conducted. Statistical Analysis Stata 14 was used to analyze the data on the RCP of all MDP aliquots. Results The RCP of ambient stored MDP aliquots was found to be ranging from 98 to 99%, while that for frozen and refrigerated ones ranged from 99 to 100%. There was also a 1% increase in RCP for both cohorts with argon gas purging (98 and 99%, respectively). Conclusion The RCP of MDP aliquots from both cohorts was much higher than the required minimum of 90% implying that there was no significant association of their stability and quality with the mode of storage. However, purging with argon gas seemed to increase the stability further in both streams. The study findings show potential for application in resource-constrained environments and centers, especially in developing countries, where challenges to maintain the cold storage chain of these important radiopharmaceuticals are likely to be encountered due to power outages.

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Coagulation Factor and Theranostics: A New Paradigm in Molecular Imaging

Cited by 3 publications

References 13 publications

68Ga-Pentixafor PET/CT for in-vivo mapping of CXCR4 receptors as potential radiotheranostic targets in soft tissue and bone sarcoma: preliminary results

68Ga-Pentixafor PET/CT for in-vivo mapping of CXCR4 receptors as potential radiotheranostic targets in soft tissue and bone sarcoma: preliminary results

Untitled

Exploring the Use of Ambientally Stored Methylene Diphosphonate Radiopharmaceutical Aliquots in Solving Challenging Situations in Developing Countries

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