Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous

Kouki, Ines; Montagner, Clémence; Mauhin, Wladimir; London, Jonathan; Lazard, Thierry; Grimbert, Sylvie; Zeller, Valérie; Lidove, Olivier

doi:10.5194/jbji-6-131-2021

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Cefazolin-associated coagulation disorders are not commonly encountered in the literature. However, there are case series reporting that vitamin K deficiency was the cause of increased INR levels [22][23][24] . It should be noted that this drug should not be used without a proper indication, especially after prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic-related adverse events and risk factors in hospitalized patients: a prospective cohort study

SOYSAL,

ŞENCAN,

KORKMAZ

2023

Cukurova Medical Journal

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Purpose: The objective of this study is to identify antibiotic-related adverse events and risk factors in hospitalized patients. Materials and Methods: This prospective cohort study included 776 inpatients who received antibiotic treatment between January 2019 and December 2020. Patients who experienced "definite" or "probable" adverse drug events (ADE) were examined using the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria. The definition and severity criteria for antibiotic-related adverse events were determined according to the Common Terminology Criteria for Adverse Events (CTCAE). Results: The overall rate of antibiotic-associated ADE was 7.9 (95%CI, 6.8-9.1) per 1000 person-days. The study identified a total of 152 adverse events in 125 patients who experienced ADE. Among the 152 adverse events, 63 (41.4%) were severe, and 89 (58.6%) were non-severe. Independent risk factors for ADE included the number of comorbidities (up to 4 times higher increased risk), number of drugs used, and duration of antibiotic administration (up to 12.3 times higher and 8% increased risk for each additional day). The most common side effects were hematological, with 45 (29.6%) cases reported in the hematological system advers events. Conclusion: The management of antibiotic durations, which is a controllable factor in the development of antibiotic-related adverse events, is crucial. Rational use of antibiotics is essential, not only in terms of preventing the development of resistance but also in terms of reducing the frequency of adverse events that may become life-threatening.

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Section: Discussionmentioning

confidence: 99%

Antibiotic-related adverse events and risk factors in hospitalized patients: a prospective cohort study

SOYSAL,

ŞENCAN,

KORKMAZ

2023

Cukurova Medical Journal

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“…This first-generation cephalosporin was previously briefly discussed in Section 4.5.1. In addition to the tetrazole heterocycle from the C7-side-chain, cefazolin contains a [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl] fragment at C3 position (Figure 14a) that resembles vitamin-K antagonists in certain respects [195]. To obtain this cephalosporin, this structural fragment has replaced the C3 acetoxy function, including a 1,3,4-thiadiazole heterocycle [29].…”

Section: Beta-lactam Antibioticsmentioning

confidence: 99%

“…Among the adverse reactions of cefazolin that have been reported are coagulation issues linked to hypovitaminosis K. These effects would be exacerbated in impaired renal function when high doses are administered, resulting in the accumulation of its active metabolite. According to some researchers, certain cefazolintreated patients may benefit from systematic vitamin-K therapy [195].…”

Section: Beta-lactam Antibioticsmentioning

confidence: 99%

The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy

Rusu,

Moga,

Uncu

et al. 2023

Pharmaceutics

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Five-membered heterocycles are essential structural components in various antibacterial drugs; the physicochemical properties of a five-membered heterocycle can play a crucial role in determining the biological activity of an antibacterial drug. These properties can affect the drug’s activity spectrum, potency, and pharmacokinetic and toxicological properties. Using scientific databases, we identified and discussed the antibacterials used in therapy, containing five-membered heterocycles in their molecular structure. The identified five-membered heterocycles used in antibacterial design contain one to four heteroatoms (nitrogen, oxygen, and sulfur). Antibacterials containing five-membered heterocycles were discussed, highlighting the biological properties imprinted by the targeted heterocycle. In some antibacterials, heterocycles with five atoms are pharmacophores responsible for their specific antibacterial activity. As pharmacophores, these heterocycles help design new medicinal molecules, improving their potency and selectivity and comprehending the structure-activity relationship of antibiotics. Unfortunately, particular heterocycles can also affect the drug’s potential toxicity. The review extensively presents the most successful five-atom heterocycles used to design antibacterial essential medicines. Understanding and optimizing the intrinsic characteristics of a five-membered heterocycle can help the development of antibacterial drugs with improved activity, pharmacokinetic profile, and safety.

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Cefazolin/rifampicin

2023

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Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous

Cited by 4 publications

References 12 publications

Antibiotic-related adverse events and risk factors in hospitalized patients: a prospective cohort study

Antibiotic-related adverse events and risk factors in hospitalized patients: a prospective cohort study

The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy

Cefazolin/rifampicin

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