Coagulation Changes During Migraine

Sicuteri, F; Michelacci, S; Lombardi, V.; Franchi, G

doi:10.1177/000331976301401204

Cited by 11 publications

(9 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This instrument can record continuously and simultaneously fibrin formation of three blood or plasma specimens and provide a permanent record photokymographically." Other studies utilizing thromboelastography for the study of overall coagulation abnormalities are reported by Rosato et al, 8 Sicuteri and co-workers, 4 and Fisch and his colleagues. 5 Kimche and Eisenkraft" had sufficient confidence in the clinical relevance of the TEG data to administer a proteinase inhibitor and low-molecularweight dextran for the treatment of postoperative thromboemboli on the basis of abnormal TEG data, and to utilize daily TEG studies as an index of adequate treatment.…”

Section: Discussionmentioning

confidence: 92%

Thromboelastographic Studies in Cerebral Infarction

Ettinger

1974

Stroke

View full text Add to dashboard Cite

Thromboelastographic Studies in Cerebral Infarction• Blood coagulability in patients following cerebral infarction was studied utilizing the thromboelastograph (TEG). Cerebral infarction patients from two separate institutions were studied within 24 to 48 hours after onset of stroke. Ninety-four stroke patients from one institution and 109 from another yielded a total stroke population of 203 patients for this study. Fifty-nine agematched normals were used as a control group. Frequency distribution curves were determined for a TEG ratio of ma/(r + k). The 59 controls exhibited a normal frequency distribution between the values of 1.6 and 4.0. Both groups of stroke patients revealed an increased number of patients with a ratio exceeding 4.0, suggesting a hypercoagulable state exists following cerebral infarction in approximately 29% to 38% of the patients studied.Additional Key Words clot lysis hypercoagulability platelet function fibrinolysis cerebrovascular disease• Our laboratory has been investigating abnormalities of blood clotting, clot lysis and platelet function in various categories of cerebrovascular disease. One of our objectives has been to identify a simple, reliable and clinically relevant test of blood or plasma which accurately identifies the overall consequences of the separate, yet simultaneously occurring reactions, which collectively result in the balance between clot formation and clot dissolution. A number of "global" tests of coagulation have been described, including the plasma recalcification test, partial thromboplastin time (PTT), the activated partial thromboplastin time, and the whole blood clotting time. All have their limitations with respect to reliability, sensitivity, and lack of correlation with clinically significant clotting or bleeding events. A somewhat different approach to a laboratory measurement of overall coagulation and fibrinolysis, which also is sensitive to platelet dysfunction, has been the development of the thromboelastograph. The thromboelastograph (TEG) provides a continuous recording of the process of blood coagulation and subsequent clot retraction. The instrument is capable of analyzing three blood samples simultaneously ( fig. 1). Stainless steel sample containers maintained at 37°C are set in motion around a vertical axis. A cylindrical dragbar is lowered into the . slowly oscillating metal containers and remains im- This investigation was supported by Research Grant NS03364 from the National Institute of Neurological Diseases and Stroke.Presented at the 46th Scientific Session of the American Heart Association, November 9, 1973, in Atlantic City, New Jersey. mobile as long as the blood or plasma sample is fluid. As the clot forms, the dragbar, suspended by the torsion wire, becomes dynamically coupled to the cup resulting in transmission of the oscillatory rotation of the cup to the cylinder. The cylinder then oscillates with an amplitude governed by the specific mechanical properties of the clot ( fig. 2). A mirror, coupled to the cylinder tors...

show abstract

Section: Discussionmentioning

confidence: 92%

Thromboelastographic Studies in Cerebral Infarction

Ettinger

1974

Stroke

View full text Add to dashboard Cite

show abstract

“…In patients suffering from acute migraine, we have demonstrated that the me tabolism of 5-hydroxytryptamine is altered (increased urinary ex cretion of 5-hydroxyindolcacetic acid). We have also observed certain changes in subcutaneous mast cells (reduction in the num ber of mast cells, and degranulation of the remaining cells), and hypocoagulability of the blood (thromboelastographic changes)-indicating the implication of histamine and heparin (26). We have detected a fall of plasma kininogen during the attack, and an in crease of the kinin-liberating activity.…”

Section: Discussionmentioning

confidence: 59%

An Antaminic Drug, BC 105, in the Prophylaxis of Migraine

Sicuteri

Franchi

Bianco

1967

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

“…Sicuteri's thrombelastographic findings toward the end of a migraine headache point in the opposite direction. 76 In previous studies of healthy individuals we did not find any correlation between levels of circulating basophils and plasma recalcification times. 83 Human basophils and tissue mast cells do not contain serotonin.…”

Section: Commentsmentioning

confidence: 57%

“…3 Toward the end of a migraine attack, Sicuteri saw thrombelastic changes similar to those seen after an injection of heparin. 76 Thonnard-Neumann exposed migraine patients to several chemical mediators which have been implicated in migraine. 85 The basophils of the patients responded to challenge with serotonin, norepinephrine, and tyramine with numerical and directional changes which were significantly different from those of nonmigrainous subjects.…”

Section: Introductionmentioning

confidence: 99%

Heparin in Migraine Headache

Thonnard-Neumann¹

1973

Headache

View full text Add to dashboard Cite

Coagulation Changes During Migraine

Cited by 11 publications

References 2 publications

Thromboelastographic Studies in Cerebral Infarction

Thromboelastographic Studies in Cerebral Infarction

An Antaminic Drug, BC 105, in the Prophylaxis of Migraine

Heparin in Migraine Headache

Contact Info

Product

Resources

About