Coagulation biomarkers for ischemic stroke

A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment

“…However, since the instrument variants are randomly distributed at birth, they are more robust to confounding and reverse causation. Several studies have evaluated the link between prestroke hemostatic factor levels and stroke risk, severity, and outcome as well as levels at admission and after r-tPA treatment [ 63 ]. High levels of hemostatic factors before stroke are generally associated with increased risk of stroke.…”

The Importance of Increased Serum GFAP and UCH-L1 Levels in Distinguishing Large Vessel from Small Vessel Occlusion in Acute Ischemic Stroke

“…By only analyzing PT and not any of the coagulation factors, which are not routinely measured, it is difficult to draw any conclusions. Numerous biomarkers related to coagulation and inflammation have been linked to AIS, but they are still unable to predict the clinical result of treatment, the severity of stroke in the acute phase, or patients who are at risk [ 38 ]. Also, none of the general markers of tissue damage, such as LDH and CRP, showed differences between the examined groups [ 39 , 40 ].…”

A High Fibrinogen-to-Albumin Ratio on Admission is Associated with Early Neurological Deterioration Following Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

“…Meanwhile, it is also an acute-phase protein that plays a role in the pathophysiological process of inflammation. 21 Many studies have shown that fibrinogen is an inflammatory marker closely related to ischemic stroke. 21 , 22 High levels of fibrinogen can increase the risk of ischemic stroke, and a recent meta-analysis reported that the risk of ischemic stroke increased by 1.47 times in patients with higher fibrinogen levels.…”