Coagulation and Platelet Activation after Retinal Vein Occlusions

Mari, Daniela; Santori, Marisa; Bertoni, G; Pm, Mannucci

doi:10.1159/000214662

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…t deceased (5)(6)(7)(8) have been reported in patients with retinal vein occlusion, reflecting an hypercoagulable state. The finding in these patients of high plasma fibrinopeptide A -a sensitive marker of in vivo thrombin activity- (9) led us to investigate the plasma levels of the major inhibitors of blood coagulation in a small series of young patients ( < yrs of age) with ischaemic CRVO. No abnormalities of the major natural anticoagulant proteins C, S and antithrombin III were observed (10).…”

Section: Introductionmentioning

confidence: 99%

Hypercoagulability and High Lipoprotein(a) Levels in Patients with Central Retinal Vein Occlusion

Bandello

Parlavecchia

et al. 1994

Thromb Haemost

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SummaryA series of coagulation parameters and lipoprotein(a) (Lp(a)) were explored in plasma from 40 patients with central retinal vein occlusion (CRVO, non-ischemic type n = 12; ischemic type n = 28) free of local and systemic predisposing factors, 1 to 12 months after the acute event. Forty age- and sex-matched patients with cataract served as controls. Prothrombin fragment 1.2 (FI.2), D-dimer, FVII:C - but not FVII: Ag - were higher and fibrinogen was lower in CRVO patients than in controls. Patients with non-ischemic CRVO had higher FI .2 and FVII:C and lower heparin cofactor II than patients with ischemic CRVO. Lp(a) levels greater than 300 mg/1 were observed in 12 patients with CRVO and in 4 controls (30% vs 10%, p <0.025). Patients with high Lp(a) - consistently associated with the S2 phenotype - had higher FVII:C, FVII:C/Ag ratio, and fibrinogen than the remaining CRVO patients. Plasma FI.2 and D-dimer correlated fairly in controls (r = 0.41) and patients with normal Lp(a) levels (r = 0.55), but they did not in the group of patients with high Lp(a) (r = 0.19), where the latter parameter was negatively related to D-dimer (r = −0.55). There was no dependence of the abnormalities observed on the time elapsed from vein occlusion. The findings of activated FVII and high FI.2, D-dimer, and Lp(a) are not uncommon in patients with CRVO. Increased thrombin formation with fibrin deposition and impaired fibrinolysis may play a role in the pathophysiology of CRVO and require specific treatment

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Section: Introductionmentioning

confidence: 99%

Hypercoagulability and High Lipoprotein(a) Levels in Patients with Central Retinal Vein Occlusion

Bandello

Parlavecchia

et al. 1994

Thromb Haemost

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“…Normal values of plasminogen and α 2 -AP excluded their involvement in impaired fibrinolysis. Defects in natural anticoagulant proteins, APCR-positive test or platelet hyperactivity have been reported in association with CRVO [21, 22, 23], but they are very uncommon conditions detected in our population. Although APCR has been described as a relatively common coagulative defect in many populations our data are not surprising.…”

Section: Discussionmentioning

confidence: 65%

Coagulative, Fibrinolytic and Metabolic Pattern in Patients with Central Retinal Vein Occlusion

Fruschelli¹,

Puccetti

Bruni

et al. 2002

Ophthalmologica

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Central retinal vein occlusion (CRVO) is an important cause of visual loss. Many risk factors have been associated with CRVO onset at various ages. Among them diabetes mellitus, hypertension, immunologic disorders, increase in blood viscosity and coagulation, decrease of fibrinolysis have been reported in many subjects. The aim of our study was to detect the metabolic, coagulative and fibrinolytic pattern in 54 patients (26 men, 28 women, mean age 50.4 ± 12.3) affected by CRVO. We excluded from the study patients with other ocular disorders. A fibrinolytic impairment is the most common feature in our population. It occurs either in dysmetabolic or in nonmetabolic subjects. Such data suggest a prominent role of the fibrinolytic system in the pathogenesis of CRVO.

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“…In this situation, rheological factors and coagulative changes can be ex pected to influence the appearance of throm bosis in the retinal vein. Patients with long standing branch retinal vein thrombosis were described to have a hypercoagulable state secondary to hemorheological, platelet and coagulative alterations [4,13,16]. Lower fibrinolytic activity and increased fi brinolytic inhibitors have been reported in the same disease [7,11], On the other hand, strong fibrinolytic capacity of central retinal vein was shown [6].…”

Section: Discussionmentioning

confidence: 99%

“…Nearly all previous studies referred to coagulative changes in unselected patients with acute or recent RVO [2,4,6,8,[14][15][16], In our patients affected by long-standing branch RVO, the presence of a statistically significant fibrinogen increase, even at dis tance from the appearance of the thrombo sis, was confirmed [15,16], However, no dif ference was seen between patients with or without new vessel formation [16]. More over a significant shortening of PTT was found in our patients.…”

Section: Discussionmentioning

confidence: 99%

“…At the level of arteriovenous crossing, endothelial swelling and proliferation alone, not neces sarily with thrombosis, seem to be capable of producing the RVO syndrome [12], Ana tomic and hemodynamic changes in the re tinal circulation and a defective control of intraocular pressure are thought to play an important role in the pathogenesis of RVO [14,17]. There is, however, some evidence suggesting that generalized hemostatic alter ations are also involved [8], Some authors have shown changes of the coagulation, platelet and fibrinolytic systems in most pa tients with occlusion of retinal vessels [2,4,8,15,16]. It is not known, however, whether these changes are primary or sec- ondary to the occlusive or thrombotic dis ease [7].…”

Section: Introductionmentioning

confidence: 99%

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Fibrinolytic Behavior in Long-Standing Branch Retinal Vein Occlusion

Patrassi

M²,

Piermarocchi³

et al. 1987

Ophthalmic Res

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The aim of our study was to evaluate the fibrinolytic system in patients with retinal branch vein occlusion (RVO). The following tests were carried out: prothrombin time, partial thromboplastin time (PTT), fibrinogen degradation products, euglobulin lysis time, fibrinogen, pasminogen, antithrombin III, α₂-antiplasmin and α₂-macroglobulin. Comparing the results of patients with those of normal controls, only the fibrinogen increase and PTT shortening were significantly different. All other tests taken into account were within normal limits. Only the patients without other associated diseases (diabetes or hypertension) showed a significant activation of fibrinolysis (either with respect to normal or to other RVO patient groups). In conclusion, no important fibrinolytic impairment was seen in our longstanding RVO patients. Fibrinolytic activation seen in patients without verified associated diseases may be related to the presence of a sound endothelium, still able to release plasminogen activators in response to RVO. The fibrinogen and PTT changes in RVO were probably due to other associated diseases.

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Coagulation and Platelet Activation after Retinal Vein Occlusions

Cited by 4 publications

References 9 publications

Hypercoagulability and High Lipoprotein(a) Levels in Patients with Central Retinal Vein Occlusion

Hypercoagulability and High Lipoprotein(a) Levels in Patients with Central Retinal Vein Occlusion

Coagulative, Fibrinolytic and Metabolic Pattern in Patients with Central Retinal Vein Occlusion

Fibrinolytic Behavior in Long-Standing Branch Retinal Vein Occlusion

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