Coagulation and inflammation in overt diabetic nephropathy: association with hyperhomocysteinemia

Aso, Yoshimasa; Yoshida, Noboru; Okumura, Ki-ichi; Wakabayashi, Shigeo; Matsutomo, Rika; Takebayashi, Kohzo; Iwamoto, Toshihiko

doi:10.1016/j.cccn.2004.05.006

Cited by 56 publications

(36 citation statements)

References 30 publications

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“…Several studies have demonstrated that Hcy levels are increased in diabetes. Elevated Hcy levels were shown to be a stronger risk factor in diabetics than in non-diabetic patients (1,19,20,21,24,29,30). Plasma Hcy levels were also found to be significantly elevated in our type 2 diabetic patients with atherosclerotic vascular disease when compared with patients without vascular disease.…”

Section: Discussionmentioning

confidence: 57%

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Relation of plasma homocysteine levels to atherosclerotic vascular disease and inflammation markers in type 2 diabetic patients

Akalın¹,

Alataş²,

Çolak³

2008

European Journal of Endocrinology

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Objective: Both hyperhomocysteinemia and increased inflammatory activity are shown to be associated with atherosclerosis. The relation of inflammatory activity to homocysteine (Hcy) levels is not well established. In the present study, we aimed to evaluate the relation of plasma Hcy levels to atherosclerotic vascular disease and inflammatory activity in type 2 diabetic patients. Design and methods: In total 90 type 2 diabetic patients were included in the study. Of these patients, 41 had established atherosclerotic vascular disease and 49 had no evidence of atherosclerotic vascular disease. Hcy levels and markers of inflammation, namely C-reactive protein, fibrinogen, erythrocyte sedimentation rate, interleukin-6, and tumor necrosis factor a (TNFa), were measured. Glucose regulation, C-peptide, lipid parameters, and renal functions were also studied. Results: Both Hcy levels and inflammation markers were all significantly elevated in patients with atherosclerotic vascular disease when compared with patients without vascular disease. Reduced renal functions were responsible for the majority of Hcy elevation in patients with vascular disease. Also, renal functions were significantly associated with both Hcy levels and inflammatory markers. There was no correlation between Hcy levels and inflammation markers except for TNFa. Conclusions: Inflammatory activity and Hcy levels are increased in type 2 diabetic patients with atherosclerotic vascular disease. Impairment of renal functions is the key factor that affects both Hcy levels and inflammation markers. Inflammation is not involved in the process by which Hcy leads atherosclerosis in type 2 diabetes.European Journal of Endocrinology 158 47-52

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Section: Discussionmentioning

confidence: 57%

“…The presence of nephropathy causes elevated plasma Hcy concentrations because of reduced clearance of Hcy (1,19,21,29). Patients with significantly elevated creatinine levels were not included in our study.…”

Section: Discussionmentioning

confidence: 99%

Relation of plasma homocysteine levels to atherosclerotic vascular disease and inflammation markers in type 2 diabetic patients

Akalın¹,

Alataş²,

Çolak³

2008

European Journal of Endocrinology

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“…It is also closely associated with the prevalence of anaemia [128] , hypertension [157] and metabolic syndrome components [131]. Microalbuminuria commonly occurs early in subjects with abnormal glucose metabolism [147,158] and is correlated with dyslipidemia [159], arterial stiffness [160,161] and increased coagulability [162] as well as inflammatory www.intechopen.com markers [163,164]. Furthermore the presence of microalbuminuria predicts ventricular dysfunction, coronary heart disease and exercise intolerance [165,166].…”

Section: Rationale For Inclusion Of the Componentsmentioning

confidence: 99%

“…There is a close relationship between inflammation and hypercoagulability [164,206]. Furthermore, hypercoagulability is also linked to the metabolic syndrome, dyslipidemia, anaemia and even the hemodynamic response to exercise [201,[207][208][209].…”

Section: Underlying Pathologymentioning

confidence: 99%

Cardiovascular Risk Assessment in Diabetes and Chronic Kidney Diseases: A New Insight and Emerging Strategies

Khoshdel¹

2012

Cardiovascular Risk Factors

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“…Hyperhomocysteinaemia may also play a role in endothelial dysfunction. Elevated plasma homocysteine levels are associated with albuminuria in both type 1 (Soedamah-Muthu et al, 2005) and type 2 diabetic patients (Aso et al, 2004). It has been suggested that elevated total homocysteine levels cause vascular complications secondary to oxidative stress, endothelial damage and decreased nitric oxide bioavailability.…”

Section: Endothelial Cell Dysfunctionmentioning

confidence: 99%

Diabetic Nephropathy: A Cardiovascular Risk Factor

Magri¹,

Fava²

2012

Diseases of Renal Parenchyma

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Coagulation and inflammation in overt diabetic nephropathy: association with hyperhomocysteinemia

Cited by 56 publications

References 30 publications

Relation of plasma homocysteine levels to atherosclerotic vascular disease and inflammation markers in type 2 diabetic patients

Relation of plasma homocysteine levels to atherosclerotic vascular disease and inflammation markers in type 2 diabetic patients

Cardiovascular Risk Assessment in Diabetes and Chronic Kidney Diseases: A New Insight and Emerging Strategies

Diabetic Nephropathy: A Cardiovascular Risk Factor

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