Coagulation and hemorheology profile of patient with stroke and COVID-19: A case series during second wave pandemic

Rasyid, Al; Timan, Ina Susianti; Riyanto, Dinda Larastika; Harris, Salim; Kurniawan, Taufik Mohammad; Mesiano, Taufik; Hidayat, Rakhmad; Wiyarta, Elvan

doi:10.3233/ch-221504

Cited by 3 publications

(3 citation statements)

References 10 publications

(18 reference statements)

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“…D-dimer is the predominant coagulation biomarker studied in critically ill COVID-19 patients, and its value is significantly increased in 50 percent of COVID-19 patients who are at significantly higher risk of death. Rasyd et al reported that D-dimer can be one predictor of mortality in COVID-19 patients with acute stroke [7][8][9][10][11]. In addition, thrombocytopenia, slight prolongation of the prothrombin time (PT), activated partial tromboplastin time (aPTT), increased plasma fibrinogen levels, and reduction in plasma fibrinogen levels in some patients were also found in critically ill COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID–19 patients: A prospective observational study

Zlojutro

Jandric

Momčičević

et al. 2023

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INTRODUCTION: This study was created to analyze dynamic alterations in coagulation, hematological and biochemical parameters and their association with mortality of COVID-19 patients. To identify the most sensitive biomarkers as predictors of mortality more research is required. METHODS: The present study was a prospective, one-year-long observational study conducted on all critically ill, COVID–19 patients with respiratory failure. The following data were collected: demographic and clinical characteristics of the study population, comorbidities, coagulation, biochemical and hematological parameters. The primary outcome was the proportion of patients who died. RESULTS: 91 patients with median age 60 (50–67), 76.9% male, met the acute respiratory distress syndrome criteria. It was tested whether dynamic change (delta-Δ) of parameters that were found to be predictors of mortality is independently associated with poor outcome. Adjusted (multivariate) analysis was used, where tested parameters were corrected for basic and clinical patients characteristics. The only inflammatory parameter which dynamic change had statistically significant odds ratio was ΔCRP (p < 0.005), while among coagulation parameters statistically significant OR was found for Δ fibrinogen (p < 0.005) in predicting mortality. CONCLUSION: Monitoring of coagulation, hematological and biochemical parameters abnormalities and their dynamical changes can potentially improve management and predict mortality in critically ill COVID –19 patients.

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Section: Introductionmentioning

confidence: 99%

Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID–19 patients: A prospective observational study

Zlojutro

Jandric

Momčičević

et al. 2023

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“…Through their adhesive properties they can bind pathogens that are subsequently removed by granulocytes [18]. In SARS-CoV-2 infections the role of thrombocytes is often associated with the development of a hypercoagulative state and thromboembolic events [19,20]. This is supported by high D-dimer being a risk factor for poor outcome [2,21,22].…”

Section: Introductionmentioning

confidence: 99%

Can we predict critical care mortality with non-conventional inflammatory markers in SARS-CoV-2 infected patients?

Rozanovic

Domokos

Márovics

et al. 2023

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BACKGROUND: Severe COVID-19 disease is associated with multiple organ involvement,then failure and often fatal outcomes.In addition,inflammatory mechanisms and cytokine storms,documented in many COVID-19 patients,are responsible for the progression of the disease and high mortality rates.Inflammatory parameters,such as procalcitonin(PCT) and C-reactive protein(CRP), are widely used in clinical practice. OBJECTIVE: To evaluate the predictive power of non-conventional inflammatory markers regarding mortality risk. METHODS: In our prospective study 52 patients were followed for 5 days after admission to an intensive care unit immediately with severe SARS-CoV-2 infection.We compared leukocyte-,platelet antisedimentation rate (LAR, PAR),neutrophil lymphocyte ratio(NLR), CRP, PCT levels. RESULTS: In non-surviving(NSU) patients LAR remained largely constant from D1 to D4 with a statistically significant drop(p < 0.05) only seen on D5.The NSU group showed statistically significant(p < 0.05) elevated LAR medians on D4 and D5, compared to the SU group.NLR values were continually higher in the non-survivor group.The difference between the SU and NSU groups were statistically significant on every examined day.PAR, CRP and PCT levels didn’t show any significant differences between the SU and NSU groups. CONCLUSIONS: In conclusion, this study suggests that LAR and NLR are especially worthy of further investigation as prognostic markers.LAR might be of particular relevance as it is not routinely obtained in current clinical practice.It would seem beneficial to include LAR in data sets to train prognostic artificial intelligence.

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“…Eritrositlerde deformabilite yeteneğinin azalması sonucunda eritrosit rijiditesinde artış meydana gelmektedir 10,11…”

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COVID-19’un Etiyopatogenezinde Hemoreolojik Parametrelerin Önemi

AZMAMEDOVA,

BAHTİYAR,

CİNEMRE

et al. 2023

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

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17 Kasım 2019’da Çin’in Wuhan kentinde ortaya çıkan COVID-19 hastalığı, 11 Mart 2020 tarihinde Dünya Sağlık Örgütü (DSÖ) tarafından küresel salgın olarak ilan edilmiştir. Ağır hastalık tablosuna ve dünya genelinde çok sayıda ölüme neden olan bu virüs, Şiddetli Akut Solunum Sendromu-Koronavirus-2 (SARS-CoV-2) olarak adlandırılmıştır. Hastalığa tüm yaş grupları hassas olmakla beraber yaşlı bireyler ile kardiyovasküler hastalık, diyabet, kronik solunum yolu hastalığı veya kanser gibi altta yatan hastalıkları olanlarda ciddi hastalık gelişme olasılığının daha yüksek olduğu gözlenmiştir. SARS-CoV-2 virüsü yüzeyindeki proteinlerden biri olan spike (S) proteini ile alt solunum yolu epitel hücrelerinde bulunan anjiyotensin dönüştürücü enzim- 2 (ACE2) reseptörlerine bağlanarak kendi genomunu hücre sitoplazmasına bırakır ve böylece yeni virüs partiküllerinin sentezini gerçekleştirir. Yapılan çalışmalarda, COVID-19 hastalığında çeşitli hematolojik ve hemoreolojik parametrelerin değiştiği belirtilmiştir. Bu hastalıkta sıklıkla gözlenen bazı hematolojik parametreler lenfopeni, nötrofili ve trombositopenidir. Enflamasyondaki artışa bağlı olarak, trombosit aktivasyonu, endotel disfonksiyonu ve staz nedeniyle hastalarda tromboz oluşumu saptanmıştır. COVID-19 koagülopatisi ile ilgili çalışmalarda, yüksek D-dimer düzeylerinin olduğu görülmüştür. Aynı zamanda artmış fibrinojenin COVID-19 hastalarında eritrosit hiperagregasyonuna neden olduğu ve bunun da kan pıhtılaşmasının gelişmesi ile ilişkili olduğu tespit edilmiştir. Eritrositlerde deformabilite yeteneğinin azalması eritrosit rijiditesinde artış ile sonuçlanmaktadır. COVID-19 hastalığında koagülasyon/fibrinolitik sistemindeki bozulmanın sonucunda, D-dimer, kan viskozitesi, eritrosit agregasyonu ve deformabilitesi gibi hemoreolojik parametrelerin artışı hastalık prognozu ile ilişkili olduğu ileri sürülmüştür. Derlemenin amacı, COVID-19’un etiyopatogenezinde hemoreolojik parametrelerin rollerini değerlendirmektir.

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Coagulation and hemorheology profile of patient with stroke and COVID-19: A case series during second wave pandemic

Cited by 3 publications

References 10 publications

Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID–19 patients: A prospective observational study

Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID–19 patients: A prospective observational study

Can we predict critical care mortality with non-conventional inflammatory markers in SARS-CoV-2 infected patients?

COVID-19’un Etiyopatogenezinde Hemoreolojik Parametrelerin Önemi

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