Coagulation and Fibrinolytic Indices During the First Trimester of Pregnancy in Women With Polycystic Ovary Syndrome: A Preliminary Study

Shan, Yu; Wang, Aiming; Sun, Yingxian; Jiang, Wen; Pang, Bao-sen; An, Zhiyuan; Du, Xin; Wang, Wei; Huang, Zhongwei

doi:10.1177/1933719113485293

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…PCOS has short-term and long-term complications such as obesity, diabetes, dyslipidemia, infertility, and the risk of cardiovascular disease. Besides these, elevated activation of the blood coagulation system of PCOS has been reported (14).…”

Section: Discussionmentioning

confidence: 99%

Family-Based Analysis of -675 4G/5G Polymorphism in the PAI-1 Gene in Chinese Polycystic Ovary Syndrome

Ge¹,

Song²,

Wang³

et al. 2021

Preprint

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Background: Insulin resistance (IR) is one of the main pathophysiology of PCOS. Previous studies have shown that 4G/5G polymorphism in promoter region of plasminogen activator inhibitor-1 gene(PAI-1) can affect insulin sensitivity by elevating the level and activity of plasma PAI-1, involved in the formation of IR. In order to elucidate the relationship between 4G/5G polymorphism of PAI-1 gene and PCOS, we used transmission disequilibrium test (TDT) to study the nuclear family of PCOS. Purpose: This study used family-based analysis of TDT to determine whether an association exists between 4G/5G polymorphism of PAI-1 gene and PCOS and in Han Chinese in order to identify PAI-1 gene as a genetic susceptibility factor for PCOS. Methods: Eight hundred and fifty-five participants consisting of 285 trios (mother, father and offspring with PCOS) were recruited from the Center for Reproductive Medicine, Shandong University, from July 2007 to August 2014. 4G/5G polymorphism of PAI-1 gene was genotyped using direct sequencing protocol and TDT was used to analyze the association between PAI-1 gene and PCOS. Results: Though the 5G allele in PAI-1 gene was overtransmitted in families, no statistical significance existed and there was no association between PAI-1 gene and PCOS. The levels of FINS, HOMA-IR and TG were significantly different between obese and lean PCOS and the parents.Conclusion: No significant evidence of association or linkage was found between 4G/5G polymorphism of PAI-1 gene and PCOS, indicating that PAI-1 gene was unlikely to play a major role in the etiology of PCOS in our sample.

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Section: Discussionmentioning

confidence: 99%

Family-Based Analysis of -675 4G/5G Polymorphism in the PAI-1 Gene in Chinese Polycystic Ovary Syndrome

Ge¹,

Song²,

Wang³

et al. 2021

Preprint

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“…Conditions other than pregnancy may also increase the risk of thromboembolic events in the gestational period. Shan et al studied pregnant women with or without PCOS during the first trimester of pregnancy and observed that pregnant women with a previous diagnosis of PCOS had a higher procoagulant state due to a higher concentration of activated clotting factors VIII and activated X 29 .…”

Section: Discussionmentioning

confidence: 99%

“…Koiou et al 40 believe that the highest activity of PAI in PCOS patients is dependent on patient body weight, which is elevated in patients with PCOS and obesity. However, Shan et al 29 and Glueck et al 23 reported that elevated PAI activity occurs regardless of the patientʼs body weight.…”

Section: Discussionmentioning

confidence: 99%

Coagulation Biomarkers in Women with Recurrent Miscarriage and Polycystic Ovarian Syndrome: Systematic Review and Meta-Analysis

Cavalcante

Sarno

Cavalcante

et al. 2019

Geburtshilfe Frauenheilkd

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Introduction Pregnant women with polycystic ovarian syndrome (PCOS) have high risk of pregnancy loss. Pathophysiological mechanisms appear to be associated with obesity, hormonal factors, or blood clotting disorders. Our aim is to perform a systematic review and meta-analysis on the relationship between coagulation disorders and risk of recurrent miscarriage (RM) in patients with PCOS and to identify coagulation biomarkers for this condition. Material and Methods PubMed and MEDLINE databases were searched for publications in English language. The search terms used included “RM”, “polycystic ovary syndrome”, “coagulation disorders”, and “thrombophilia”. Odds ratios (ORs) and 95% confidence intervals (CIs) for miscarriage in different RM groups (with and without PCOS). Results A total of 575 publications including the search terms were identified. Six studies were included for qualitative analysis, and five were included for quantitative analysis (meta-analysis). We found no association between RM and inherited thrombophilias in patients with PCOS: (1) Factor V Leiden (OR, 0.74; 95% CI, 0.38 – 1.45; p = 0.38); (2) C677T methylenetetrahydrofolate reductase polymorphism (MTHFR) (OR, 1.01; 95% CI, 0.64 – 1.59; p = 0.97); and (3) A1297C MTHFR polymorphism (OR, 1.08; 95% CI, 0.62 – 1.89; p = 0.77). Other potential biomarkers were identified, with emphasis on plasminogen activator inhibitor type 1. Conclusion Data available in the current literature revealed that there was no association between RM and inherited thrombophilias in patients with PCOS. RM patients with PCOS have a high risk of thromboembolic events.

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“…Women with PCOS are more likely to develop complications of the metabolic syndrome such as obesity, hypertension, dyslipidemia, and diabetes, which are in turn severe risk factors for cardiovascular disease [7]. PCOS patients have elevated activation of the blood coagulation system [9]. Thrombus formation results from the disturbance between pro-thrombotic and anti-thrombotic factors that controls clotting balance: this disturbance may occur due to an ongoing stimulus to thrombogenesis, a defect of the natural anti-coagulant or fibrinolytic system [10].…”

Section: Introductionmentioning

confidence: 99%

Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism and Polycystic Ovary Syndrome Risk: A Meta Analysis

Liu

Sun

Jiang

et al. 2014

J Assist Reprod Genet

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Coagulation and Fibrinolytic Indices During the First Trimester of Pregnancy in Women With Polycystic Ovary Syndrome: A Preliminary Study

Cited by 4 publications

References 32 publications

Family-Based Analysis of -675 4G/5G Polymorphism in the PAI-1 Gene in Chinese Polycystic Ovary Syndrome

Family-Based Analysis of -675 4G/5G Polymorphism in the PAI-1 Gene in Chinese Polycystic Ovary Syndrome

Coagulation Biomarkers in Women with Recurrent Miscarriage and Polycystic Ovarian Syndrome: Systematic Review and Meta-Analysis

Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism and Polycystic Ovary Syndrome Risk: A Meta Analysis

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