Coagulation and fibrinolytic factors in normotensive hypertension-prone men

Increased Heart Rate and Haemostatic Balance Disorders Pre-exist the Established Hypertension

“…Our results show that in normotensive adults who eventually developed EH, body mass index (BMI), SBP, DBP, resting HR and fibrinogen, PAI-1 and tPA-Ag levels are significantly Table The values (mean ± SD) of the measured parameters in the group who developed essential hypertension versus the values of the subjects who remained normotensive higher at baseline compared to subjects who remained normotensive. Although several studies have already observed such abnormalities in borderline hypertensives or subjects with parental hypertension (8,9), to our knowledge, this is the first study that has indicated these differences in subjects who subsequently developed established hypertension. Although functional variations for the fibrinogen and PAI-1 gene have been described, abnormalities regarding coagulation-fibrinolysis might be related to early metabolic interrelated disturbances and these are present even in the early stages of hypertension (10).…”

“…Several studies have shown the prognostic value of increased heart rate (HR) for the manifestation of EH (5), while it is considered as an independent risk factor for the development of cardiovascular episodes and sudden death (6). It is worth noticing that increased HR and haemostatic-fibrinolytic balance disorders have been observed not only in hypertensive patients, but in normotensive subjects with a family history of hypertension as well (7)(8)(9). This implies that these abnormalities pre-exist the established hypertension, but it is not known whether these observations are associated with the future development of EH or their clinical importance.…”

Plasma Platelet-activating Factor (PAF) Levels and Desmopressin Response in Children with Hemophilia A and von Willebrand's Disease

“…higher at baseline compared to subjects who remained normotensive. Although several studies have already observed such abnormalities in borderline hypertensives or subjects with parental hypertension (8,9), to our knowledge, this is the first study that has indicated these differences in subjects who subsequently developed established hypertension. Although functional variations for the fibrinogen and PAI-1 gene have been described, abnormalities regarding coagulation-fibrinolysis might be related to early metabolic interrelated disturbances and these are present even in the early stages of hypertension (10).…”

Insulin Sensitivity and Hemostatic Factors in Clinically Healthy 58-year-old Men

“…However, the extreme complexity of the coagulation and fibrinolysis systems and the delicate balance between these systems make it difficult to clarify the net effect on thrombogenesis of changes in one separate factor. As an example, subjects with a family history of hypertension had higher PAI-1 levels than matched controls (10). However, the former also had higher levels of the anticoagulant protein C, of its cofactor protein S and of antithrombin III, indicating improved protective mechanisms against hemostatic disturbances (10).…”

“…As an example, subjects with a family history of hypertension had higher PAI-1 levels than matched controls (10). However, the former also had higher levels of the anticoagulant protein C, of its cofactor protein S and of antithrombin III, indicating improved protective mechanisms against hemostatic disturbances (10).…”