2021
DOI: 10.3390/ijms22062834
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Coagulation and Fibrinolysis in Obstructive Sleep Apnoea

Abstract: Obstructive sleep apnoea (OSA) is a common disease which is characterised by repetitive collapse of the upper airways during sleep resulting in chronic intermittent hypoxaemia and frequent microarousals, consequently leading to sympathetic overflow, enhanced oxidative stress, systemic inflammation, and metabolic disturbances. OSA is associated with increased risk for cardiovascular morbidity and mortality, and accelerated coagulation, platelet activation, and impaired fibrinolysis serve the link between OSA an… Show more

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Cited by 17 publications
(18 citation statements)
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References 163 publications
(236 reference statements)
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“…The study of Bikov et al indicated that the increased risk of CVD from sleep disorders may be associated with accelerated blood clotting and platelet activation. 29 Patients with depression may have increased platelet activation, which was thought to contribute to the development of atherosclerosis and peripheral artery disease. 30 , 31 Activation of the coagulation system by depressive symptoms and sleep disorders may be another common pathway to increase the risk of CVD.…”
Section: Discussionmentioning
confidence: 99%
“…The study of Bikov et al indicated that the increased risk of CVD from sleep disorders may be associated with accelerated blood clotting and platelet activation. 29 Patients with depression may have increased platelet activation, which was thought to contribute to the development of atherosclerosis and peripheral artery disease. 30 , 31 Activation of the coagulation system by depressive symptoms and sleep disorders may be another common pathway to increase the risk of CVD.…”
Section: Discussionmentioning
confidence: 99%
“…Hypoxemia and altered hemodynamics in OSA can precipitate a pro-coagulant state, which could further accentuate coagulopathy related to COVID-19. 41 The angiotensin converting enzyme 2 (ACE2) has been identified as the entry receptor of SARS-CoV-2. 42 Both in OSA and in obese patients, there is an increased expression of ACE2 receptors, which would favor the union of the virus.…”
Section: Obstructive Sleep Apneamentioning
confidence: 99%
“…In addition, a previous study of OSA patients compared to non-OSA patients reported a profile of 65 proteins, highlighting a differentially expressed profile pattern of TFPI in patients with OSA [52]. These pathways have been previously described as targets of the pathophysiological consequences of OSA [37,40,50,53]. Specifically, these three proteins play a key role in regulating the inflammatory response and oxidative stress, together with an effect on endothelial dysfunction.…”
Section: Discussionmentioning
confidence: 91%
“…STK4 is a key component of the Hippo signaling pathway and is thus an essential regulator of cardiac development and regeneration/repair after injury [46,47]. TFPI is implicated in the development of atherosclerosis [48,49] and is associated with fibrinogen levels [50,51]. In addition, a previous study of OSA patients compared to non-OSA patients reported a profile of 65 proteins, highlighting a differentially expressed profile pattern of TFPI in patients with OSA [52].…”
Section: Discussionmentioning
confidence: 98%