Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study

Patel, GovindR; Thanvi, I; Nadeem, Mohammad; Kanwaria, Rahul

doi:10.4103/1995-7645.370149

Cited by 6 publications

(4 citation statements)

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“…Hemorrhagic manifestations, shock and plasma leakage is due to the decreased levels of circulating protein C, S, antithrombin III and elevated levels of tissue factor, thrombomodulin. Similarly, reduction in coagulation such as II, V, VII, VIII, IX, X, antithrombin, and alpha-2 antiplasmin factors was reported in DHF [ 22 , 35 , 38 ].…”

Section: Discussionmentioning

confidence: 75%

“…Platelets count was significantly lower in DHF cases as compared to patients with DF. Thrombocytopenia was common laboratory finding in dengue viral infection but it was more prevailing in DHF patients in current study [ 35 ]. The hemorrhagic tendency increases because dengue virus affects the bone marrow and decreases the platelet cells production.…”

Section: Discussionmentioning

confidence: 76%

“…Petechia and melena were significantly more prevalent in DHF ( P = 0.001) (Table 2 ). These clinical manifestations and warning signs were excluded from the multivariate analysis because they are highly relevant to DHF, serve as diagnostic tools for the clinical case definition of DHF, and are consistent with previous research [ 35 , 36 ]. Delayed hospitalization with DVI results in deterioration of clinical manifestations, which favors the progression of DF to DHF through the development of hemorrhagic manifestations.…”

Section: Discussionmentioning

confidence: 97%

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Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Riaz,

Harun,

Mallhi

et al. 2024

BMC Infect Dis

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Background Dengue Viral Infection (DVI) has become endemic in Pakistan since the first major outbreak in Karachi in 1996. Despite aggressive measures taken by relevant authorities, Pakistan has been dealing with a worsening dengue crisis for the past two decades. DHF is severe form of dengue infection which is linked with significant morbidity and mortality. Early identification of severe dengue infections can reduce the morbidity and mortality. In this context we planned current study in which we find out the different factors related with DHF as well as clinical laboratory features of DHF and compare them to DF so that patients can be best evaluated for DHF and managed accordingly at admission. Methods Retrospective study conducted over a period of 6 years (2013–2018) in two tertiary care hospitals in Pakistan. Data were collected by using a pre-structured data collection form. Data were statistically analyzed to determine the clinical and laboratory characteristics of DVI and risk factors of dengue hemorrhagic fever (DHF). Results A total 512 dengue cases (34.05 ± 15.08 years; Male 69.53%) were reviewed. Most common clinical manifestations of DVI were fever (99.60%), headache (89.1%), chills (86.5%), rigors (86.5%), myalgia (72.3%). Less common clinical manifestations were vomiting (52.5%), arthralgia (50.2%) and skin rashes (47.5%). Furthermore, nasal bleeding (44.1%), gum bleeding (32.6%), pleural effusion (13.9%) and hematuria (13.1%) were more profound clinical presentations among DHF patients. Mortality rate was 1.5% in this study. Logistic regression analysis indicated that delayed hospitalization (OR: 2.30) and diabetes mellitus (OR:2.71), shortness of breath (OR:2.21), association with risk groups i.e., living near stagnant water, travelling to endemic areas, living in endemic regions (OR:1.95), and presence of warning signs (OR:2.18) were identified as risk factors of DHF. Statistically we found that there is strong association of diabetes mellitus (DM) with DHF while the patient suffering from DM individually had higher odds (2.71) of developing DHF than patients without disease. Conclusions The current study demonstrated that the clinical and laboratory profiles of DF and DHF are significantly distinct. Significant predictors of DHF were advanced age, diabetes mellitus, ascites, pleural effusion, thick gallbladder and delayed hospitalization. The identification of these factors at early stage provides opportunities for the clinicians to identify high risk patients and to reduce dengue-related morbidity and mortality.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 97%

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Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Riaz,

Harun,

Mallhi

et al. 2024

BMC Infect Dis

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“…[13] Despite the high frequency of prolonged APTT and PT, clinically significant bleeding manifestations are less common. [14] In the event of bleeding, blood transfusion requirements are low. In a retrospective study done over 7 years in a tertiary hospital in South India, clinically significant bleeding manifestations occurred in 44.7% of patients with dengue infection but only 1.2% of them required packed cell transfusion.…”

Section: Haemostatic Abnormalities In Dengue Infectionmentioning

confidence: 99%

Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications

Tan,

Choong,

Abid

et al. 2024

Preprint

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Dengue infection is caused by the Dengue virus (DENV) and is transmitted to humans by infected female Aedes aegypti and Aedes albopictus mosquitoes. There are nearly 100 million new dengue cases yearly in more than 120 countries with a five-fold increase in incidence over the past four decades. While many patients experience a mild illness, a subset suffer from severe disease which can be fatal. Dysregulated immune responses are central to the pathogenesis of dengue, and haematologic manifestations are a prominent feature of severe disease. While thrombocytopaenia and coagulopathy are major causes of bleeding in severe dengue, leucocyte abnormities are emerging as important markers of prognosis. In this review, we provide our perspective on the clinical aspects and pathophysiology of haematologic manifestations in dengue. We also discuss the key gaps in our current practice and areas to be addressed by future research.

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Dengue como causa de abscesos intrabdominales, presentación de un caso clínico y revisión de la literatura

Rodríguez-Chávez,

Vásquez-Tirado,

Romero-Diaz

et al. 2024

Medicina Clínica Práctica

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Coagulation abnormalities and their relationship with bleeding manifestations in patients with dengue-A single center observational study

Cited by 6 publications

References 0 publications

Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis

Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications

Dengue como causa de abscesos intrabdominales, presentación de un caso clínico y revisión de la literatura

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