Coagulase-negative staphylococci and sternal infections after cardiac operation

Tegnell, Anders; Arén, Claes; Öhman, Lena

doi:10.1016/s0003-4975(99)01563-5

Cited by 94 publications

(61 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of sternal infection after cardiac operations ranges from 0.9 % to 20 % in various studies and the incidence of mediastinitis is 1-2 % in most reports 1 . The mortality rate for patients with deep sternal infections ranges from 9.8 to 14 % 2 .…”

Section: Introductionmentioning

confidence: 99%

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

Pojar

Mandak²,

Maláková³

et al. 2008

BIOMED PAP

View full text Add to dashboard Cite

Aim: Surgical-site infections are very serious complications of cardiac operations. Use of cardiopulmonary bypass (CPB) is associated with profound physiological changes, which aff ects the pharmacokinetic behaviour of prophylactic antibiotics. The aim of this study was to monitor tissue concentrations of cefuroxime in peripheral tissue (skeletal muscle) during cardiac surgery using CPB by means of a microdialysis.Methods: Eleven adult patients operated on using CPB were included in the study. Cefuroxime was the prophylactic antibiotic and study drug given. Microdialysis was performed by probe CMA 60 inserted into the patient's left deltoid muscle. Samples of dialysates were collected at intervals: before CPB, each 30 minutes of CPB and at the end of CPB. Samples of blood were collected at intervals: incision, start of CPB, each 30 minutes of CPB, at the end of CPB and at the end of surgery.

show abstract

Section: Introductionmentioning

confidence: 99%

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

Pojar

Mandak²,

Maláková³

et al. 2008

BIOMED PAP

View full text Add to dashboard Cite

show abstract

“…Although the early symptoms and signs of sternal wound infection are vague 8 , this system has proved to be effective in detecting early infection with a specificity of 96%. We believe that the sensitivity has not accurately been reflected in 52%, as many patients with wound infection may not have positive microbiology as prophylactic perioperative antibiotics precede wound swabbing.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier recognition of sternal wound complications and aggressive treatment has probably contributed to the relatively low mortality rate seen in some studies 7 . Early symptoms of wound infection after cardiac surgery are often vague 8 . In most cases traditional markers of infection such as fever, leukocytosis and Creactive protein (CRP) have proved unreliable 9 .…”

Section: Introductionmentioning

confidence: 99%

An approach to improve early detection of sternal wound infection

Howlader¹,

Smith²,

Madden³

2009

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

We developed a reproducible and reliable method of using a rubber stamp prospectively to document appearances of the sternal wound. 395 consecutive patients undergoing median sternotomy for cardiac procedures were studied over a period of four months. Data were collected by the Senior House Officer during the ward round for all patients at Day 3 and Day 7 post-operatively. Data were entered for 303 patients using the rubber stamp. 78 patients had no stamp entered in their case notes. 21 patients were recorded as having abnormal wounds, 11 of whom confirmed positive microbiological growth. On the other hand, 282 patients were recorded to have normal wounds, 10 of which had positive bacterial growth. Our initial results have been encouraging with almost 80% compliance and 96% specificity. A simple recording system consisting of proven signs of infection known to medical practitioners was our tool.

show abstract

“…Ванкомицин был выбран в связи с этиологией стернальной инфекции, в част-ности медиастинита. Наиболее распространенными этиологическими возбудителями являются золоти-стый стафилококк, коагулазонегативные стафилокок-ки и реже грамотрицательные бактерии [28,29,31].…”

Section: вве дениеunclassified

Choise of local antibacterial medications for prevention of sternal infection

et al. 2017

View full text Add to dashboard Cite

Infection of wounds in surgery is one of the most frequent complications in the postoperative period. The development of this complication increases the duration of hospitalization, resulting in higher treatment costs, as well as the impact to the level of hospital mortality. There are many methods are exist to avoid this complication, which are allow to decontamination of pathogenic and conditionally pathogenic microorganisms including applying antimicrobial agents prior to surgery. One such method is intravenous antibiotic shortly before surgery. But there is evidence in the literature of successful local antibiotics in neurosurgery, traumatology and orthopedics, operations on the thorax and abdominal organs, including for prevention of sternal infection. For this purpose most often used vancomycin and gentamicin. This is often a causative agent of wound infection, which is a gram-positive flora: Staphylococcus aureus and Staphylococcus epidermidis. To increase the effectiveness of preventive measures to reduce the incidence of sternal infection intraoperatively topically applied antibiotics in various forms when closing the wound. For parenteral administration of antibiotics effective therapeutic dose is often not achieved, because it depend on the time period since the introduction of the substance until the start of the operation [3]. Local application of antibiotics to a reduction of frequency wound infection, as concentration of a substance is directly dependent on the applied dose.

show abstract

Coagulase-negative staphylococci and sternal infections after cardiac operation

Cited by 94 publications

References 17 publications

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

Tissue and Plasma Concentrations of Antibiotic During Cardiac Surgery With Cardiopulmonary Bypass - Microdialysis Study

An approach to improve early detection of sternal wound infection

Choise of local antibacterial medications for prevention of sternal infection

Contact Info

Product

Resources

About