Coagulase-Negative Staphylococcal Endocarditis

Baddour, Larry M.

doi:10.1001/archinte.1986.00360130145020

Cited by 34 publications

(4 citation statements)

References 20 publications

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“…These authors generated a series of colonial variants differing in slime production and virulence in the rat endocarditis model and also demonstrated a high rate of phenotypic variation among other CNS strains. Variants differing in the degree of resistance to antibiotics have been detected previously, both in vitro [7,24] and in vivo [1,2,6].…”

Section: Discussionmentioning

confidence: 83%

“…In a recent study [1], coagulase-negative staphylococci (CNS) were demonstrated to have the greatest propensity for colonial variation compared with all other species of bacteria isolated from blood cultures. Phenotypic variation in colonial morphology among strains of CNS isolated from humans and experimental animals has been the subject of several other reports [1][2][3][4][5][6][7][8][9][10] and has been suggested as a virulence mechanism of these organisms [4,5,8]. In this report, we describe the derivation and characterization of a series of phenotypic variants generated from two colonial morphotypes of Staphylococcus epidermidis isolated from a patient with native valve endocarditis.…”

Section: Introductionmentioning

confidence: 90%

“…Type C variants were more diverse than the other types in their enzyme activities, biochemical capabilities and API profiles. (2) (2) ce .a . Restriction endonuclease digestion of plasmid DNA isolated from five variants representing the major colonial morphotypes.…”

Section: Other Types Of Colonial Variationmentioning

confidence: 99%

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A study of phenotypic variation ofStaphylococcus epidermidisusing Congo red agar

Deighton¹,

Capstick

Borland

1992

Epidemiol. Infect.

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This study examines a series of phenotypic variants of Staphylococcus epidermidis that were generated from a pair of parent variants, isolated from valvular tissue of a patient with prosthetic valve endocarditis. The variants were initially classified by examining their colonial morphology on Congo red agar. In addition to differences in Congo red binding and colonial morphology, they differed in the expression of several surface components and enzymes. Despite these phenotypic differences, all variants had the same restriction endonuclease profile of plasmid DNA. Examination of a collection of clinical isolates demonstrated that phenotypic variation is a common property of S. epidermidis. The ability to express different combinations of surface components and enzymes could contribute to the virulence of S. epidermidis strains by enabling these organisms to colonize a range of diverse environments.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 90%

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A study of phenotypic variation ofStaphylococcus epidermidisusing Congo red agar

Deighton¹,

Capstick

Borland

1992

Epidemiol. Infect.

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“…Particular attention should be drawn to S. epidermidis. This skin commensal is being increasingly recognized as a major cause of serious human infection, mainly in association with medical devices (31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 99%

Acute Cutaneous Complications and Catheter Needle Colonization During Insulin-Pump Treatment

et al. 1987

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Forty unselected type I (insulin-dependent) diabetic patients with insulin pumps were examined three times for cutaneous complications and bacterial colonization of their subcutaneous catheter needles. Fifty-eight of the 120 needles were contaminated, 42 of them with Staphylococcus epidermis. Cutaneous complications, i.e, erythema of greater than or equal to 1-mm diam at the needle-insertion site, were seen with similar frequency. Significantly fewer (P less than .001) cutaneous complications and contaminated needles were found when a disinfectant was sprayed on the skin before insertion of the needle. The results indicate that infection along the indwelling subcutaneous needle contributes substantially to cutaneous complications during continuous subcutaneous insulin infusion and that these complications can successfully be prevented by appropriate antiseptic measures.

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Bloodstream Infection and Endocarditis

Seifert

Wisplinghoff

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Coagulase-Negative Staphylococcal Endocarditis

Cited by 34 publications

References 20 publications

A study of phenotypic variation ofStaphylococcus epidermidisusing Congo red agar

A study of phenotypic variation ofStaphylococcus epidermidisusing Congo red agar

Acute Cutaneous Complications and Catheter Needle Colonization During Insulin-Pump Treatment

Bloodstream Infection and Endocarditis

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