Coacervate-directed synthesis of CaCO₃ microcarriers for pH-responsive delivery of biomolecules

Abstract

pH-responsive, protein loaded calcium carbonate microcarriers are synthesized by the combination of complex coacervation and mineralization for drug delivery applications.

CaCO3 thin-film formation mediated by a synthetic protein-lysozyme coacervate

“…Similarly, amorphous CaCO 3 (ACC) was prepared in other reports using poly(acrylic acid)-based coacervates, which were used for micromolding of CaCO 3 into micropatterned casts that yield smooth surfaces. 31,32 From these results, we suggest that a thin lm was formed at the liquidliquid interface of the GG1234/lysozyme complex coacervation that was mainly composed of poorly crystalline CaCO 3 and proteins. The amino acid sequence of GG1234 was obtained from the genome sequence of Gallus gallus (jungle fowl), which was available from the National Center for Biotechnology Information (NCBI) database but was removed in a recent update of the genome annotation process.…”

Biodegradable Nanoparticles of Polyacrylic Acid–Stabilized Amorphous CaCO3 for Tunable pH‐Responsive Drug Delivery and Enhanced Tumor Inhibition

“…In particular, the high specific surface area and porosity of ACC have been proved as a perfect candidate in drug delivery for both basic and acidic poorly soluble drugs . Indeed, ACC has shown to be an ideal nanomaterial for the fabrication of novel nano/micro‐carriers for biomedical applications . For example, ACC can be utilized as a template to prepare a sacrificial porous core in mesoporous silica nanospheres for drug preloading .…”

Sodium Salicylate Mediated Ionic Liquid Based Catanionic Coacervates as Membrane‐Free Microreactors for the Selective Sequestration of Dyes and Curcumin

“…Surfactant based liquid‐liquid phase separation, i. e. coacervation is among the new age techniques to sequester the charged dyes. Coacervate based systems are used in food industry, cosmetics, to encapsulate and deliver dyes, ‐drugs, ‐genes, ‐proteins, in protocell formation, as protocell assembly to name a few . Garenne et.al examined the sequestration of more than 30 cationic, anionic and zwitter‐ionic dyes within the coacervates according to its surface charge density .…”