Co60Vitamin B12 Binding Capacity of Normal Human Saliva.

Bertcher, Robert W.; Meyer, Leo M.; Miller, Inez F.

doi:10.3181/00379727-99-24402

Cited by 10 publications

(3 citation statements)

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“…R proteins are a family of cobalamin binding proteins that move more rapidly than intrinsic factor on electrophoresis (63, 65). These R proteins are present in gastric juice (64) and in saliva (15), from which they been purified (6,19) and shown to bind cobalamin at both acidic and neutral pH (7). Allen et al (7) further showed that human salivary R protein-bound cobalamin with an affinity that was 50-and 3-fold higher than those of human intrinsic factor (IF) at pH 2 and pH 8.0, respectively.…”

Section: Cobalamin Binding To R Protein and Intrinsic Factor (If)mentioning

confidence: 99%

Absorption and Transport of Cobalamin (Vitamin B₁₂)

Seetharam

Alpers

1982

Annu. Rev. Nutr.

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This review apprises the reader of recent advances in cobalamin absorption and transport since 1970. This field has been of interest to gastroenterologists, hematologists, and biochemists as well as nutritionists. Clinical conditions leading to cobalamin deficiency present especially to the first two of these specialties. Many recent advances involve biochemical definition of the specific transport proteins themselves. Full understanding of the multiple clinical conditions associated with cobalamin deficiency requires some knowledge of these proteins. We do not discuss every paper in the field, especially the early literature (see 47, 61, 150). Despite rapid strides in understanding the mechanism of absorption and transport of cobalamin both in prokaryotic and eukaryotic cells, the complete sequence of events during cellular absorption at the plasma membrane level and events in the cells that mediate intracellular movement of cobalamin have not been elucidated completely. Here we emphasize the current state of knowledge about cobalamin absorption and transport in man and other mammalian systems, particularly the physiological role and biochemical nature of proteins involved (intrinsic factor, intrinsic factor-cobalamin receptor, transcobalamins).

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Section: Cobalamin Binding To R Protein and Intrinsic Factor (If)mentioning

confidence: 99%

Absorption and Transport of Cobalamin (Vitamin B₁₂)

Seetharam

Alpers

1982

Annu. Rev. Nutr.

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“…Saliva appears to possess a protein which is capable of binding added vitamin B12 (Bertcher et al 1958, Grasbeck 1956). …”

Section: Salivamentioning

confidence: 99%

“…Bertcher & Meyer (1958) considered that the pattern of binding suggested that only a single binding factor was present. Grasbeck's group (Grasbeck et al 1962) have found confirmatory evidence for this, and have demonstrated that the binder has the immunological characteristics of their ' R binder, and, like the 'R binder in other tissues, e. g., serum, leukocytes, this does not possess intrinsic factor activity (Grasbeck 1956, Grasbeck et al 1962).…”

Section: Salivamentioning

confidence: 99%