CO2-responsive deep eutectic solvents for the enhanced extraction of hesperidin from Fertile orange peel

Wang, Shanshan; Lei, Tian; Liu, Leilei; Tan, Zhijian

doi:10.1016/j.foodchem.2023.137255

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…The number and type of hydrogen bonds present in the DESs have a profound impact, not only in the extraction yield but also in the nature of bioactive compound to be extracted. Theoretical studies demonstrated that hydrogen and π-bonds were the main factors affecting the extraction of hesperidin from orange peel using a DES of triethanolamine/4-methoxyphenol (1:1) with a water content of 35% [ 169 ].…”

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

“…In this way, the target compounds are separated from the DES, and at the same time, the extraction yield is increased [ 188 ]. Other approaches were developed to separate the DESs from the extracts based on temperature [ 189 ], pH [ 190 ], and CO 2 [ 169 ]. Tang et al [ 189 ] prepared hydrophobic temperature-switchable DESs to extract Lycium barbarum polysaccharides.…”

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

“…By adjusting the pH, the DESs were separated and reused for further extractions. Wang et al [ 169 ] synthesized CO 2 -responsive DESs to extract hesperidin from orange peel. The reversible phase transformation of the DES solution was achieved by bubbling CO 2 /N 2 in the DES solution to recover the hesperidin from the top phase.…”

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

See 2 more Smart Citations

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Ferreira,

Sarraguça

2024

Pharmaceuticals

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The extraction of bioactive compounds of pharmaceutical interest from natural sources has been significantly explored in recent decades. However, the extraction techniques used were not very efficient in terms of time and energy consumption; additionally, the solvents used for the extraction were harmful for the environment. To improve the environmental impact of the extractions and at the same time increase the extraction yields, several new extraction techniques were developed. Among the most used ones are ultrasound-assisted extraction and microwave-assisted extraction. These extraction techniques increased the yield and selectivity of the extraction in a smaller amount of time with a decrease in energy consumption. Nevertheless, a high volume of organic solvents was still used for the extraction, causing a subsequent environmental problem. Neoteric solvents appeared as green alternatives to organic solvents. Among the neoteric solvents, deep eutectic solvents were evidenced to be one of the best alternatives to organic solvents due to their intrinsic characteristics. These solvents are considered green solvents because they are made up of natural compounds such as sugars, amino acids, and carboxylic acids having low toxicity and high degradability. In addition, they are simple to prepare, with an atomic economy of 100%, with attractive physicochemical properties. Furthermore, the huge number of compounds that can be used to synthesize these solvents make them very useful in the extraction of bioactive compounds since they can be tailored to be selective towards a specific component or class of components. The main aim of this paper is to give a comprehensive review which describes the main properties, characteristics, and production methods of deep eutectic solvents as well as its application to extract from natural sources bioactive compounds with pharmaceutical interest. Additionally, an overview of the more recent and sustainable extraction techniques is also given.

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Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

See 1 more Smart Citation

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Ferreira,

Sarraguça

2024

Pharmaceuticals

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show abstract

“…The number and type of hydrogen bonds present in the DESs has a profound impact, not only in the extraction yield but also in the nature of bioactive compound to be extracted. Theoretical studies demonstrated that hydrogen and π-bonds were the main factors affecting the extraction of hesperidin from orange peel using a DES of triethanolamine: 4methoxyphenol (1:1) with a water content of 35% [174].…”

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

“…In this way the target compounds are separated from the DES and at the same time the extraction yield is increased [193]. Other approaches were developed to separate the DESs from the extracts based on temperature [194], pH [195], and CO2 [174]. Tang et al [194] prepared hydrophobic temperature-switchable DESs to extract Lycium barbarum polysaccharides.…”

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Ferreira,

Sarraguça

2023

Preprint

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The pharmaceutical industry is one of the largest pollutants and generator of toxic solvent resi-dues for the environment and human beings. In the last decade, there has been a huge evolution in the design and development of new environmentally friendly products and processes, in re-sponse to the global environmental concern and the growing demand for products with quality ingredients and manufacturing processes aimed at achieving sustainability. Consumers are looking for products with the benefits of natural products, with sustainable and environmentally friendly formulations with few synthetic molecules as possible. Thus, based on the origins of the pharmaceutical industry, it is important to return to Nature and enjoy the benefits that natural products bring to us. Deep eutectic solvents appear as an alternative to toxic solvents commonly used to extract bioactive compounds. These solvents are considered green solvents because they are made up of natural compounds such as sugars, amino acids, and carboxylic acids. In addition, they are simple to prepare, with an atomic economy of 100%, with attractive physicochemical properties. This paper is a comprehensive review in which is described the main properties, characteristics, and production methods of deep eutectic solvents as well as its application to extract from natural sources bioactive compounds with pharmaceutical interest.

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Facile construction of pectin-based hesperidin microcapsules: Solubilization, stability, loading process, and release mechanism

Zhou,

Li,

Jiang

et al. 2024

Food Chemistry

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CO2-responsive deep eutectic solvents for the enhanced extraction of hesperidin from Fertile orange peel

Cited by 5 publications

References 33 publications

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Facile construction of pectin-based hesperidin microcapsules: Solubilization, stability, loading process, and release mechanism

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