Co-ultramicronized palmitoylethanolamide/luteolin treatment as add-on to intensive neuro-rehabilitation in a young patient with traumatic brain injury

Palma, Luisa De; Santamato, Andrea; Monitillo, Vincenzo; Fiore, Pietro

doi:10.23736/s0393-3660.17.03564-1

Cited by 3 publications

(2 citation statements)

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“…According to recent observation, PEA appears to be a molecule that functions as a pro-homeostatic protective response to cellular damage and is typically up-regulated in disease circumstances [ 115 , 117 ]. It has analgesic, anticonvulsant, antibacterial, antipyretic, antiepileptic, immunomodulatory, and neuroprotective effects [ 118 , 119 ].…”

Section: Natural Products In the Management Of Dementiamentioning

confidence: 99%

Therapeutic potential of clinically proven natural products in the management of dementia

Ansari,

Sohel,

Haidary

et al. 2024

Heliyon

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Section: Natural Products In the Management Of Dementiamentioning

confidence: 99%

Therapeutic potential of clinically proven natural products in the management of dementia

Ansari,

Sohel,

Haidary

et al. 2024

Heliyon

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“…Nowadays, neuroinflammation is considered a key element in the pathogenesis of a broad spectrum of neurological diseases, from neurodegenerative conditions, such as Alzheimer’s disease [ 39 , 40 , 41 , 42 , 43 ] and Parkinson’s disease [ 44 ], to traumatic diseases, such as traumatic brain injuries [TBI] [ 45 , 46 , 47 , 48 , 49 ], strokes [ 50 ], and other conditions where neuronal excitability is increased, such as epilepsy [ 51 ]. Moreover, recently, attention has been called to the significant effect of PEA in clinical conditions involving the higher functions of CNS, such as cognitive impairment [ 52 ] and mood disorders [ 53 ].…”

Section: Pea and Neuroinflammationmentioning

confidence: 99%

Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function

et al. 2022

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Recently, the endocannabinoid system has attracted growing attention from the scientific community for its involvement in homeostatic and pathological processes as they pertains to human physiology. Among the constituents of the endocannabinoid system, the molecule palmitoyl ethanolamide has particularly been studied for its ability to reduce several inflammatory processes involving the central nervous system. Here, we reviewed published literature and summarized the main targets of the palmitoyl ethanolamide, along with its unique possible mechanisms for restoring correct functioning of the central nervous system. Moreover, we have highlighted a less-known characteristic of palmitoyl ethanolamide, namely its ability to modulate the function of the neuromuscular junction by binding to acetylcholine receptors in different experimental conditions. Indeed, there are several studies that have highlighted how ultra-micronized palmitoyl ethanolamide is an interesting nutraceutical support for the treatment of pathological neuromuscular conditions, specifically when the normal activity of the acetylcholine receptor is altered. Although further multicentric clinical trials are needed to confirm the efficacy of ultra-micronized palmitoyl ethanolamide in improving symptoms of neuromuscular diseases, all the literature reviewed here strongly supports the ability of this endocannabinoid-like molecule to modulate the acetylcholine receptors thus resulting as a valid support for the treatment of human neuromuscular diseases.

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Palmitoylethanolamide: A Natural Compound for Health Management

Clayton¹,

Hill

Bogoda

et al. 2021

IJMS

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All nations which have undergone a nutrition transition have experienced increased frequency and falling latency of chronic degenerative diseases, which are largely driven by chronic inflammatory stress. Dietary supplementation is a valid strategy to reduce the risk and severity of such disorders. Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. This review summarizes the functionality of PEA, supporting its use as an important dietary supplement for lifestyle management.

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Co-ultramicronized palmitoylethanolamide/luteolin treatment as add-on to intensive neuro-rehabilitation in a young patient with traumatic brain injury

Cited by 3 publications

References 0 publications

Therapeutic potential of clinically proven natural products in the management of dementia

Therapeutic potential of clinically proven natural products in the management of dementia

Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function

Palmitoylethanolamide: A Natural Compound for Health Management

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