Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer
Kaiqi Zhang,
Yuan Xu,
Xusheng Chang
et al.
Abstract:Background
CD47, serving as an intrinsic immune checkpoint, has demonstrated efficacy as an anti-tumor target in hematologic malignancies. Nevertheless, the clinical relevance of CD47 in gastric cancer and its potential as a therapeutic target remains unclear.
Methods
The expression of CD47 in clinical gastric cancer tissues was assessed using immunohistochemistry and Western blot. Patient-derived cells were obtained from gastric cancer tissues and… Show more
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