Co-surfactant effect of polyethylene glycol 400 on microemulsion using BCS class II model drug

Taher, Salam Shanta; Al-Kinani, Khalid Kadhem; Hammoudi, Zahraa Mohsen; Ghareeb, Mowafaq M.

doi:10.51847/1h17tzqgyi

“…PEG 400 1–2.5% was included in the form of gel-based nanoemulsions containing 6-gingerol 10%, oleic acid 1–5%, Tween 20 4–10%, and water 82.5–94%, for wound treatment [ 76 ]. PEG 400 6.5–10% was selected in formulations designed for intranasal delivery to increase the rate of survival in glioblastoma treatment [ 77 ], while concentrations of 15–21% were selected for designing microemulsions for the oral delivery of carvedilol as suitable solubilizer that acts synergistically with peppermint oil 10% and Tween 80 15–21% [ 78 ]. Amounts of 6–9% PEG 400 were tested for antifungal buccal sprays, emphasizing the importance of the stabilizers for microemulsion development [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Talianu,

Dinu-Pîrvu,

Ghica

et al. 2024

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This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral candidiasis and to improve its bioavailability. The formulation and preparation process was combined with a mathematical approach using a 23-full factorial plan. Fluid and gel-like microemulsions were obtained and analyzed considering pH, conductivity, and refractive index, followed by extensive analyses focused on droplet size, zeta potential, rheological behavior, and goniometry. In vitro release tests were performed to assess their biopharmaceutical characteristics. Independent variables coded X1-Oleic acid (%, w/w), X2-Tween 20 (%, w/w), and X3-PEG 400 (%, w/w) were analyzed in relationship with three main outputs like mean droplet size, work of adhesion, and diffusion coefficient by combining statistical tools with response surface methodology. The microemulsion containing miconazole base–2%, oleic acid–5%, Tween 20–40%, PEG 400–20%, and water–33% exhibited a mean droplet size of 119.6 nm, a work of adhesion of 71.98 mN/m, a diffusion coefficient of 2.11·10−5 cm2/s, and together with remarked attributes of two gel-like systems formulated with higher oil concentrations, modeled the final optimization step of microemulsions as potential systems for buccal delivery.

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“…Origin 2018 64Bit software 6 (free alternative, GnuPlot) was used to generate a ternary plot using the gathered data. 7 …”

Section: Methodsmentioning

confidence: 99%

Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system

Muhammed

¹

,

Al-Kinani

²

2023

F1000Res

Self Cite

2

0

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Background: The nonsteroidal anti-inflammatory medication meloxicam (MLX) belongs to the oxicam family and is used to reduce inflammation and pain. The aim of this study was to improve MLX's dispersibility and stability by producing it as a liquid self-microemulsifying drug delivery system since it is practically insoluble in water. Methods: Five different formulations were made by adjusting the amounts of propylene glycol, Transcutol P, Tween 80, and oleic acid oil and establishing a pseudo-ternary diagram in ratios of 1:1, 1:2, 1:3, 1:4, and 3:4, respectively. All of the prepared formulations were tested for a variety of properties, including thermodynamic stability, polydispersity index, particle size distributions, dilution resistance, drug contents, dispersibility, in vitro solubility of the drug, and emulsification time. Results: F5 was chosen as the optimal MLX liquid self-microemulsion due to its higher drug content (99.8%), greater in vitro release (100% at 40 min), smaller droplet size (63 nm), lower polydispersity index (PDI) value (0.3), and higher stability (a zeta potential of -81 mV). Conclusions: According to the data provided here, the self-microemulsifying drug delivery system is the most practical method for improving the dispersibility and stability of MLX.

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“…Origin 2018 64Bit software 6 (free alternative, GnuPlot) was used to generate a ternary plot using the gathered data. 7 Preparing MLX liquid SMEDDS A series of liquid SMEDDS formulas were created (Table 1) by combining oleic acid as the oil, Tween 80 as the surfactant, Transcutol P as the co-surfactant and propylene glycol as the cosolvent in the ratios (1:1, 1:2, 1:3, 1:4, and 3:4), while keeping the oil: Smix ratio constant (1:9). The SEDDS components, such surfactants and oils, poorly dissolve MLX.…”

Section: Saturation Solubility Studiesmentioning

confidence: 99%

Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system

Muhammed

¹

,

Al-Kinani

²

2023

F1000Res

Self Cite

3

0

View full text Add to dashboard Cite

Background: The nonsteroidal anti-inflammatory medication meloxicam (MLX) belongs to the oxicam family and is used to reduce inflammation and pain. The aim of this study was to improve MLX's dispersibility and stability by producing it as a liquid self-microemulsifying drug delivery system since it is practically insoluble in water. Methods: Five different formulations were made by adjusting the amounts of propylene glycol, Transcutol P, Tween 80, and oleic acid oil and establishing a pseudo-ternary diagram in ratios of 1:1, 1:2, 1:3, 1:4, and 3:4, respectively. All of the prepared formulations were tested for a variety of properties, including thermodynamic stability, polydispersity index, particle size distributions, dilution resistance, drug contents, dispersibility, in vitro solubility of the drug, and emulsification time. Results: F5 was chosen as the optimal MLX liquid self-microemulsion due to its higher drug content (99.8%), greater in vitro release (100% at 40 min), smaller droplet size (63 nm), lower polydispersity index (PDI) value (0.3), and higher stability (a zeta potential of -81 mV). Conclusions: According to the data provided here, the self-microemulsifying drug delivery system is the most practical method for improving the dispersibility and stability of MLX.

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Co-surfactant effect of polyethylene glycol 400 on microemulsion using BCS class II model drug

Cited by 17 publications

References 22 publications

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Development and Characterization of New Miconazole-Based Microemulsions for Buccal Delivery by Implementing a Full Factorial Design Modeling

Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system

Formulation and in vitro evaluation of meloxicam as a self-microemulsifying drug delivery system

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