CO₂ promoted photoredox/Ni-catalyzed semi-reduction of alkynes with H₂O

Abstract

CO2-promoted photoredox/Ni dual catalyzed semi-reduction of alkynes with water has been developed, which provides a method for the synthesis of Z-alkenes in high yields with high stereoselectivity under mild conditions.

CO2 and palladium enabled highly chemoselective hydroxylation of gem-difluorocyclopropanes

“…Moreover, we characterized the nucleophile activating role of CO 2 through key mechanistic experiments. The herein presented results should encourage the development of further challenging coupling reactions with weak X–H nucleophiles such as water, by means of CO 2 catalysis, 74–77 and in general the use of CO 2 in synthetic method development. 78…”